Untitled

Felix, Elizabeth R.; Widerström-Noga, Eva

doi:10.1682/jrrd.2008.04.0058

Cited by 67 publications

(9 citation statements)

References 59 publications

(116 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is consistent with studies in healthy, non-disabled subjects and in other patient populations (31,46). A study by Felix and Widerström-Noga examined vibration thresholds across two test sessions in a sample of SCI patients with neuropathic pain and a sample of non-disabled control subjects, and the results showed that the ICCs were in the substantial range (0.86-0.90) (25). Two other studies have remarked on the stability of VPTs obtained in persons with SCI (24,47).…”

Section: Reliabilitysupporting

confidence: 88%

“…Subjects were asked to indicate by clicking the mouse as soon as they felt the vibratory sensation. The next trial started again from the baseline value, with the average of three successive trials (separated by 10 s each) (25) taken as the vibration perception threshold (VPT) for each site. To include data for analyses at sites where no sensation was evoked during testing, we recorded the maximum amplitude of the vibratory stimulus (cutoff value) (VPT=130 µm) (25).…”

Section: Testsmentioning

confidence: 99%

“…The next trial started again from the baseline value, with the average of three successive trials (separated by 10 s each) (25) taken as the vibration perception threshold (VPT) for each site. To include data for analyses at sites where no sensation was evoked during testing, we recorded the maximum amplitude of the vibratory stimulus (cutoff value) (VPT=130 µm) (25). According to the standard of normal values specified by the VSA-3000 manufacturer, VPTs were divided into three groups (normal, decreased, and undetected) ( Table 2).…”

Section: Testsmentioning

confidence: 99%

“…In this manner, we could ask subjects to compare the quality of the sensation to the quality evoked at the reference hand. Appreciation of vibratory sensation at each site was separately scored on a 0-10 numerical rating scale scale (25,35), with 0 = "undetected, " 1-9 = "decreased, " 10 = "normal. "…”

Section: Physical Examination Testing Using 128 Hz Tuning Forkmentioning

confidence: 99%

“…VPT assessed by VSA-3000 has been most commonly used in detecting peripheral neuropathy (9,(12)(13)(14)(19)(20)(21)(22)(23). Recent studies showed that QST using VSA-3000 (or other devices) was also a useful adjunct measurement with good reliability of detection thresholds in central nervous system diseases (6,(24)(25)(26)(27)(28). However a specific analysis of its diagnostic accuracy with VSA-3000, especially as diagnostic outcome measures in patients with stroke and SCI, has not been fully established.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

VSA-3000: A Quantitative Vibration Sensation Testing Device for Patients With Central Nervous System Injury

2020

View full text Add to dashboard Cite

Objective: To investigate the effect of using Vibration Sensory Analyzer-3000 (VSA-3000) in patients with impaired vibration sensation caused by central nervous system injury. Design: Prospective observational study. Setting: A university hospital for the research and clinical practice of rehabilitation. Subjects: Sixty patients (30 stroke and 30 spinal cord injury) were recruited, aged between 20 and 71 years old, under stable medication. Interventions: Not applicable. Main Measure: VSA-3000 threshold test, tuning fork test and somatosensory evoked potential (SSEP) measurement. Results: Test-retest reliability was determined based on data collected from 60 subjects, and the intraclass correlation coefficient (ICC) for vibration perception thresholds (VPTs) was in the "substantial" range. The kappa value between VSA-3000 and SSEP was 0.877, which was higher than that of tuning fork (κ = 0.732). VSA-3000 had good diagnostic accuracy with a sensitivity of 94.8%, specificity of 92.9%, and positive-predictive value of 93.8% and negative-predictive value of 94.0%, each value was higher than that of tuning fork. The area under the receiver operating characteristic curve (AUC) of VSA-3000 was 0.95 (95% CI: 0.91 to 0.98) and that of tuning fork was 0.89 (95% CI: 0.85 to 0.95), and there was a significant difference between the two values (P = 0.0216). The types of injury and age were the independent correlates of the VPTs. Conclusion: The present study provides preliminary evidence that VSA-3000 is a non-invasive and convenient quantitative testing instrument with good diagnostic accuracy, and it may be useful as a screening tool for assessing impaired vibration sensation caused by central nerve injury.

show abstract

Section: Reliabilitysupporting

confidence: 88%

Section: Testsmentioning

confidence: 99%

Section: Testsmentioning

confidence: 99%

Section: Physical Examination Testing Using 128 Hz Tuning Forkmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

VSA-3000: A Quantitative Vibration Sensation Testing Device for Patients With Central Nervous System Injury

2020

View full text Add to dashboard Cite

show abstract

Assessment of Somatosensory Function in Patients With Idiopathic Dry Eye Symptoms

Galor

Levitt

McManus³

et al. 2016

JAMA Ophthalmol

Self Cite

View full text Add to dashboard Cite

IMPORTANCE Somatosensory dysfunction likely underlies dry eye (DE) symptoms in many individuals yet remains an understudied component of the disease. Its presence has important diagnostic and therapeutic implications. OBJECTIVE To assess the integrity of nociceptive system processes in persons with DE and ocular pain using quantitative sensory testing (QST) techniques applied at a site remote from the eye. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional study conducted at Miami Veterans Affairs Hospital included 118 individuals with a wide variety of DE symptoms and signs. The study was conducted from October 31, 2013, to January 28, 2016. INTERVENTIONS Individuals completed questionnaires regarding ocular symptoms (5-Item Dry Eye Questionnaire [DEQ5], Ocular Surface Disease Index [OSDI], and Neuropathic Pain Symptom Inventory modified for the eye [NPSI-E]), psychological status, and medication use and underwent an ocular surface examination. The QST metrics included measures of vibratory and thermal thresholds and cold and hot pain temporal summation (surrogate measures of central sensitization) on the forearm. MAIN OUTCOMES AND MEASURES Correlations among DE and ocular pain symptom severity with QST metrics measured on the forearm. The OSDI score ranges from 0 to 100, with 100 indicating the most severe DE symptoms. The DEQ5 score ranges from 0 to 22, with the highest score indicating the most severe symptoms, and the NPSI-E score ranges from 0 to 100, with the highest score indicating the most severe symptoms. Psychological state was measured with the 9-item Patient Health Questionnaire, the PTSD Checklist-Military Version for PTSD, and the Symptom Checklist-90 for anxiety. RESULTS Of the 118 patients who participated in the study, 105 (88.9%) were men (mean [SD] age, 60 [10] years), and a mean of 41% had PTSD, 10% depression, and 0.93% anxiety. Using stepwise linear regression analyses, significant associations were identified between overall DE symptom severity and posttraumatic stress disorder scores and tear breakup time (DEQ5 model: R = 0.54; OSDI model: R = 0.61, P < .001). All other variables (ie, demographics, comorbidities, medications, tear film factors, and QST metrics) dropped out of these models. When specifically considering neuropathic-like qualities of DE pain, however, anxiety and hot pain temporal summation at the forearm explained 17% of the variability in ocular burning (R = 0.41; P < .001), and PTSD score, tear breakup time, and hot pain temporal summation at the forearm explained 25% of the variability in sensitivity to wind (R = 0.50; P < .001) and 30% of the variability in total NPSI-E scores (R = 0.55; P < .001). CONCLUSIONS AND RELEVANCE Our findings demonstrate that neuropathic-like DE pain symptom severity correlates with quantitative measures of pain sensitivity at a site remote from the eye. This result provides additional evidence that DE symptoms are not only manifestations of a local disorder but also involve somatosensory dysfunction beyond the trigeminal system.

show abstract

The rocky road to translation in spinal cord repair

Filli

Schwab

2012

Annals of Neurology

View full text Add to dashboard Cite

Over the past 2 decades, the biological understanding of the mechanisms underlying structural and functional repair of the injured central nervous system has strongly increased. This has resulted in the development of multiple experimental treatment strategies with the collective aim of enhancing and surpassing the limited spontaneous recovery occurring in animal models and ultimately humans suffering from spinal cord or brain injuries. Several of these experimental treatments have revealed beneficial effects in animal models of spinal cord injury. With the exception of neurorehabilitative therapies, however, therapeutic interventions that enhance recovery are currently absent within the clinical realm of spinal cord injury. The present review surveys the prospects and challenges in experimental and clinical spinal cord repair. Major shortcomings in experimental research center on the difficulty of closely modeling human traumatic spinal cord injury in animals, the small number of investigations done on cervical spinal injury and tetraplegia, and the differences in lesion models, species, and functional outcome parameters used between laboratories. The main challenges in the clinical field of spinal cord repair are associated with the standardization and sensitivity of functional outcome measures, the definition of the inclusion/exclusion criteria for patient recruitment in trials, and the accuracy and reliability of an early diagnosis to predict subsequent neurological outcome. Research and clinical networks were recently created with the goal of optimizing animal studies and human trials. Promising clinical trials are currently in progress. The time has come to translate the biologic-mechanistic knowledge from basic science into efficacious treatments able to improve the conditions of humans suffering from spinal cord injury.

show abstract

Untitled

Cited by 67 publications

References 59 publications

VSA-3000: A Quantitative Vibration Sensation Testing Device for Patients With Central Nervous System Injury

VSA-3000: A Quantitative Vibration Sensation Testing Device for Patients With Central Nervous System Injury

Assessment of Somatosensory Function in Patients With Idiopathic Dry Eye Symptoms

The rocky road to translation in spinal cord repair

Contact Info

Product

Resources

About