Myxopapillary Ependymoma: A Surveillance, Epidemiology, and End Results Analysis of Epidemiology and Outcomes

Abstract

breast cancer. This population of patients presented with brain metastases was treated in the Institut Curie between 2014 and 2015 with TDM1 and concomitant (4) or sequential (8) radiosurgery with or without whole brain irradiation. We studied: local control (brain and target zone), clinical response and radiological (radio necrosis) the early and late side effects. Results: The mean age was 38 (23-53) years old at the time of diagnosis of breast cancer and 46 (28-61) years at the diagnosis brain metastatic evolution in good general condition's patients. In the concurrent group the response rate was 75% with one complete response, one partial response, one stable disease, and one local progression. Comparatively, in the sequential group the response rate was 85.7% with two complete responses, two partial responses, 8 stable diseases, and two local progressions. No patient experienced interruption of her irradiation for the reason of side effects. About 50% of the patients were asymptomatic after the treatment. The radio necrosis was observed in 50% in the concurrent group and 28.6% sequential group in the other with a similar rate of edema for the two groups (25% and 28.6%). Conclusion: In these very first series we found that association of T-DM1 and radiosurgery is feasible but can increase the radio necrosis without clinical translation. Larger prospective studies with longer follow-up are needed to evaluate this population of patients.