Myxomatous neoplasms in the perineal region of baboons

Abstract

Background In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years. Methods We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants. Results Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features. Conclusion Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.

Spontaneous and experimental malignancies in non‐human primates

“…Spontaneous tumors of various localization observed in the colony during the whole period of its existence are described in these publications. They consider in detail ovarian tumors , tumors of the urogenital tract , neuroendocrine tumors of the liver , cancers of the mammary glands , myxomatous tumors of perineal region [, ], tumors of the cervix uteri , keratinizing cancers of the oral cavity, trachea, genital organs . In the summarizing publication and also in our publications are described tumors in young animals and in very young once: brain glioblastoma in an infant baboon at the age of 1 month, cancer of the ovary in 6‐month‐old infant, and lung tumor in 9‐month‐old infant .…”