Myxoma of the Ovary

Superficial angiomyxoma in a pregnant cow

“…Immunohistochemically, neoplastic cells of angiomyxoma often display variable positivity for α-SMA and desmin (Gajanayake et al 2010 ; Lee et al 2016a ; Okada et al 2005 ; Shaver, Kolker & Bennett 2018 ), and a myofibroblastic phenotype has been hypothesised (Gajanayake et al 2010 ). Regarding the intensity of alcian blue staining, the intercellular matrix may stain weakly in angiomyxoma, in contrast to the dense positive staining usually observable in myxoma due to the presence of hyaluronic acid (Bedir, Yılmaz & Calapoğlu 2018 ). Additionally, in humans, neutrophilic infiltration not associated with necrosis is considered a unique histologic feature of superficial angiomyxoma, distinguishing it from other lesions with a myxoid component and representing an important histologic clue for the differential diagnosis.…”

“…Regarding the intensity of alcian blue staining, the intercellular matrix may stain weakly in angiomyxoma, in contrast to the dense positive staining usually observable in myxoma due to the presence of hyaluronic acid (Bedir, Yılmaz & Calapoğlu 2018). Additionally, in humans, neutrophilic infiltration not associated with necrosis is considered a unique histologic feature of superficial angiomyxoma, distinguishing it from other lesions with a myxoid component and representing an important histologic clue for the differential diagnosis.…”

Myxoma of the Ovary: in Regard to Bedir et al. (Balkan Med J 2018;35:120-121)

“…In the January 2018 issue of Balkan Medical Journal, Bedir et al (1) reported a new case of an ovarian myxoma, an exceedingly rare ovarian tumor. Although ovarian myxoma is a benign tumor that occurs predominantly in young women in whom fertility preservation is a major concern, the authors suggest that total excision of the tumor together with the adnexal structures is advisable because of the difficulty of total excision of viscous material that may cause recurrences.…”

“…Ovarian myxoma frequently occurs in women at the reproductive age (9/16 cases, including ours, were aged ≤40 years), with a peak of incidence lying between ages 12 and 25 years (n=9/16, 56%). The available clinical characteristics, management, and the outcome of the nine cases aged ≤40 years (1,2,3,4,5) are summarized in the Table 1. Ovarian masses in young women require a thoughtful consideration to the preservation of the ovary if the preoperative suspicion of malignancy is low and there is no evidence of malignancy intraoperatively (6,7,8,9,10).…”