Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution

Abstract

Objectives The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern. Methods 148 MLs were analyzed. The sites of metastases were investigated. Results Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases. Conclusion Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.

Time Trends and Prognostic Factors for Overall Survival in Myxoid Liposarcomas: A Population-Based Study

“…Unfortunately, the exact tumor size was not available in our database, necessitating us to use the T -stage to derive tumor size information. For that reason, we used 5 cm as a cut-off point for tumor size, instead of the 10 cm cut-off used in most other studies [ 8 , 10 , 11 , 24 , 25 ]. Even though tumor location is generally considered as a prognostic factor in STSs [ 27 ], and to the best of our knowledge, it has never been reported as a prognostic factor for OS in MLS to date.…”

“…MLS is relatively sensitive to radiotherapy (RT) [ 12 , 17 , 18 ] and chemotherapy [ 19 , 20 ], in comparison to other STSs. Local control is achieved in 60–98% of patients [ 4 , 7 , 8 , 11 – 14 , 18 , 21 – 23 ], resulting in favorable 5-year overall survival (OS) rates of 67–90% [ 5 , 9 , 11 – 13 , 21 , 23 – 25 ].Although sample sizes in most of the previous studies are small due to the rarity of the disease, several prognostic factors in MLS have been identified. Age at diagnosis >45years, tumor size >10 cm, presence of >5% round cell component, and positive resection margins are associated with worse (disease-specific) survival [ 5 , 7 , 8 , 11 , 13 , 21 , 23 – 25 ].…”

“…Local control is achieved in 60–98% of patients [ 4 , 7 , 8 , 11 – 14 , 18 , 21 – 23 ], resulting in favorable 5-year overall survival (OS) rates of 67–90% [ 5 , 9 , 11 – 13 , 21 , 23 – 25 ].Although sample sizes in most of the previous studies are small due to the rarity of the disease, several prognostic factors in MLS have been identified. Age at diagnosis >45years, tumor size >10 cm, presence of >5% round cell component, and positive resection margins are associated with worse (disease-specific) survival [ 5 , 7 , 8 , 11 , 13 , 21 , 23 – 25 ]. To overcome these small sample sizes and generate sufficient statistical power, national cancer registries have great potential to come to more definitive conclusions based on unselected observations [ 24 ].The purpose of this study was to characterize demographics, with the round cell component in particular (I), OS rates (II) and prognostic factors (III) for MLS in a nationwide retrospective cohort of 901 patients treated between 1989 and 2016 in The Netherlands.…”

Cardiac metastases from primary myxoid liposarcoma of the thigh: A case report

“…Patients with MLS tend to have metastases to extrapulmonary sites, such as retroperitoneum, abdominal wall, abdominal cavity, and bone, even in the absence of pulmonary metastases [2,7]. Although several authors have reported a high proportion of extrapulmonary metastases of MLS, ranging from 50-78% of all metastases [7][8][9][10], cardiac metastasis is extremely rare. Here we present a case of cardiac metastasis that occurred in a patient with primary MLS of the thigh.…”

Cardiac metastases from primary myxoid liposarcoma of the thigh: a case report

“…Patients with MLS tend to have metastases to extrapulmonary sites, such as retroperitoneum, abdominal wall, abdominal cavity, and bone, even in the absence of pulmonary metastases [2,7]. Although several authors have reported a high proportion of extrapulmonary metastases of MLS, ranging from 50 to 78% of all metastases [7][8][9][10], cardiac metastasis is extremely rare. Here we present a case of cardiac metastasis that occurred in a patient with primary MLS of the thigh.…”