Myxoid Clear Cell Sarcoma

Kim, You Chan; Vandersteen, Daniel P.; Jung, Hong-Geun

doi:10.1097/01.dad.0000141547.31306.4e

Cited by 15 publications

(7 citation statements)

References 15 publications

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“…In the described case, the IHQ studies supported the diagnosis of myxoid ES. Locoregional lymph node involvement, vascular invasion, tumor size larger than 2 cm, deep localization, presence of necrosis, and a high mitotic index in excess of 2 per 10 high power fields are poor prognosis risk factors [ 14 , 15 ]. However, these prognostic factors have not been well established for vulvar ES due to its rare incidence [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Extremely Rare Case of Vulvar Myxoid Epithelioid Sarcoma

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et al. 2015

Case Reports in Obstetrics and Gynecology

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Epithelioid sarcoma is a distinct sarcoma type with specific morphology and immunophenotype. An epithelioid sarcoma of the vulva is an extremely rare and aggressive tumor and most commonly occurs on the labia majora in women of reproductive age. Only few cases have been reported, especially with the presence of focal myxoid changes. Early diagnosis is difficult because of its benign appearance as a painless subcutaneous nodule. Optimal treatment is not well established due to its rarity. We report a successfully approached case of vulvar epithelioid sarcoma that occurred in a 34-year-old female patient, treated with wide local excision, and review of the current medical literature.

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Section: Discussionmentioning

confidence: 99%

Extremely Rare Case of Vulvar Myxoid Epithelioid Sarcoma

Rego

Cintra

Netto

et al. 2015

Case Reports in Obstetrics and Gynecology

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“…The stroma varies from minimal to prominent and hyalinized. Morphologic variations include CCS with myxoid areas, a microcystic pattern, rhabdoid cells, and multinucleated wreath-like giant cells [323,326,327]. Gastrointestinal CCS lack intracellular melanin and show numerous scattered osteoclast-like giant cells [317][318][319]328].…”

Section: The Pecoma Familymentioning

confidence: 99%

Soft Tissue Tumors of Uncertain Origin

2012

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Many soft tissue tumors of childhood lack obvious differentiation toward a defined mesenchymal tissue type or have a phenotype that does not correspond to any defined normal tissue. These challenging tumors are currently regarded as neoplasms of uncertain differentiation. Nonetheless, there have been great strides in the understanding of their pathologic and genetic features and biologic underpinnings. The application of new genetic information to the pathologic diagnosis among this group of tumors is an emerging area in diagnostic pediatric pathology. This article reviews the clinicopathologic features of tumors of uncertain and/or miscellaneous origin, with an emphasis on the unique aspects of these neoplasms in children and adolescents, use of diagnostic adjuncts, and differential diagnosis.

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“…128,139,[149][150][151][152][153][154] Recently, a myxoid variant of clear cell sarcoma, the soft tissue counterpart of cutaneous melanoma, has been described. 155 Distinction of primary from secondary myxoid melanoma rests on the demonstration in the primary lesions of an atypical intraepidermal melanocytic proliferation. 141 The pattern of intraepidermal melanocyte proliferation can be subtle, with irregular nesting that is only focal.…”

Section: Histologymentioning

confidence: 99%

Unusual variants of malignant melanoma

2006

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A potential diagnostic pitfall in the histologic assessment of melanoma is the inability to recognize unusual melanoma variants. Of these, the more treacherous examples include the desmoplastic melanoma, the nevoid melanoma, the so-called 'minimal-deviation melanoma,' melanoma with prominent pigment synthesis or 'animal-type melanoma,' and the malignant blue nevus. Also problematic are the unusual phenotypic profiles seen in vertical growth phase melanomas; these include those tumors whose morphological peculiarities mimic cancers of nonmelanocytic lineage and those melanomas that express aberrant antigenic profiles not commonly associated with a melanocytic histogenesis. Metaplastic change in melanoma, balloon cell melanoma, signet-ring cell melanoma, myxoid melanoma, small cell melanoma and rhabdoid melanoma all have the potential to mimic metastatic and primary neoplasms of different lineage derivations. Abnormal immunohistochemical expression of CD 34, cytokeratins, epithelial membrane antigen, and smooth muscle markers as well as the deficient expression of S100 protein and melanocyte lineage-specific markers such as GP100 protein (ie HMB-45 antibody) and A103 (ie Melan-A) also present confusing diagnostic challenges. In this review, we will discuss in some detail certain of these novel clinicopathologic types of melanoma, as well as the abnormal phenotypic expressions seen in vertical growth phase melanoma. Modern Pathology (2006) 19, S41-S70. doi:10.1038/modpathol.3800516Keywords: melanoma; variants; phenotype; immunohistochemistry; morphology Desmoplastic melanoma Introduction and Clinical FeaturesDemoplastic melanoma is a rare variant of malignant melanoma first recognized in 1971.1 Desmoplastic and neurotropic melanoma may be mistaken clinically for a scar, a fibroma, a basal cell carcinoma, or a fibromatosis. Sometimes there is pronounced mucin deposition that imparts a boggy quality to the lesion. 2,3 The clinical clue to the diagnosis, when present, is cutaneous or mucosal pigmentation overlying a palpable dermal or submucosal nodule. That said, only half of desmoplastic melanomas are clinically pigmented. 3 Desmoplastic melanomas tend to occur in the head and neck area and the upper back [4][5][6][7] but are also seen in mucosal sites such as the vulva or gingiva 8 and in acral locations. Typically, they occur in older patients, with mean ages in the larger series falling into the sixth to eighth decades of life. 4,6,[9][10][11][12][13][14][15] Larger series show a male preponderance of 1.75 to 1. 15 Although any given desmoplastic melanoma can be deeply invasive, when matched for depth of invasion, they are associated with a lesser risk of metastatic disease than conventional melanomas of similar depth. The classical clinical finding is that of a pale or fleshy firm nodule reminiscent of a scar, which tends to delay clinical diagnosis and biopsy. Carlson et al,6 who reported an equal distribution in men and women, found most tumors to be located in the head and neck area (75%) and to be nonpigment...

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Myxoid Clear Cell Sarcoma

Cited by 15 publications

References 15 publications

Extremely Rare Case of Vulvar Myxoid Epithelioid Sarcoma

Extremely Rare Case of Vulvar Myxoid Epithelioid Sarcoma

Soft Tissue Tumors of Uncertain Origin

Unusual variants of malignant melanoma

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