Myxoid chondrosarcoma of the scrotum: a case report and review of the literature

Méndez-Probst, Carlos E.; Erdeljan, Petar; Castonguay, Mathieu; Gabril, Manal; Wehrli, Bret; Razvi, Hassan

doi:10.5489/cuaj.893

Cited by 6 publications

(8 citation statements)

References 11 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considered to be slow growing, it generally arises in the deep soft tissues of the proximal limbs but several unusual sites such as the scrotum and finger have been documented 3–5. The typical appearance is of a lobulated mass composed of gelatinous nodules with internal fibrous septa 6.…”

Section: Introductionmentioning

confidence: 99%

“…The typical appearance is of a lobulated mass composed of gelatinous nodules with internal fibrous septa 6. Although originally believed to be a variant of chondrosarcoma, the World Health organization has classified it as a tumor of uncertain differentiation due to its lack of cartilaginous differentiation 3. Additionally, cytogenetic studies have shown that EMC is a unique entity with a reciprocal translocation, t(9;22) (q22;q12), not seen in conventional skeletal chondrosarcoma 7–12.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 Considered to be slow growing, it generally arises in the deep soft tissues of the proximal limbs but several unusual sites such as the scrotum and finger have been documented. 3 – 5 The typical appearance is of a lobulated mass composed of gelatinous nodules with internal fibrous septa. 6 Although originally believed to be a variant of chondrosarcoma, the World Health organization has classified it as a tumor of uncertain differentiation due to its lack of cartilaginous differentiation.…”

Section: Introductionmentioning

confidence: 99%

“… 6 Although originally believed to be a variant of chondrosarcoma, the World Health organization has classified it as a tumor of uncertain differentiation due to its lack of cartilaginous differentiation. 3 Additionally, cytogenetic studies have shown that EMC is a unique entity with a reciprocal translocation, t(9;22) (q22;q12), not seen in conventional skeletal chondrosarcoma. 7 – 12 Despite being considered a low grade sarcoma with a prolonged clinical course, extraskeletal myxoid chondrosarcoma has been shown to have a high rate of local recurrence and metastasis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases

Kapoor

Shinagare

Jagannathan

et al. 2014

Radiology and Oncology

View full text Add to dashboard Cite

BackgroundThe aim of the study was to evaluate the clinical and imaging features of extraskeletal myxoid chondrosarcoma (EMC) including initial presentation, recurrence, and metastases.Patients and methods.In this institutional review board-approved retrospective study, imaging features of 13 patients with pathologically proven EMC seen from August 1995 to December 2011 were analyzed. The group included 3 women and 10 men and the mean age was 54 years (range 29–73 years). Imaging studies were evaluated by two radiologists in consensus. Location, size, and imaging features of primary tumors were recorded as well as the presence of recurrent disease and location of metastases.ResultsAmong 13 patients, 3 died during the timeframe of this study. Nine patients had primary tumor in the lower extremity, and average tumor size was 9.3 cm (range 3.3–18 cm). On MRI, primary tumors were hyperintense on T2, isointense to muscle on T1, and demonstrated peripheral/septal enhancement. Three patients had local recurrence and 12 had metastatic disease, with lung involvement being the most common. Tumor density on contrast enhanced CT ranged from 8.2 to 82.9 Hounsfield unit (HU). FDG-PET/CT imaging was performed in 3 patients. One patient had no FDG avid disease and 2 patients had metastatic disease with standard uptake values (SUV) of 2.8 and 7.4. The patient with intense FDG uptake demonstrated more solid appearing tumor burden and had the shortest survival.ConclusionsEMC is a rare tumor that often occurs in the lower extremities and frequently metastasizes to the lungs. Increased tumor density and increased FDG uptake may be related to more aggressive disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases

Kapoor

Shinagare

Jagannathan

et al. 2014

Radiology and Oncology

View full text Add to dashboard Cite

show abstract

“…There have been 10 case reports of this disease, and only 1 of them affecting the bladder. [ 18 ] This is the first reported case of extraskeletal myxoid chondrosarcoma affecting the bladder in Saudi Arabia. Last but not least, malignant rhabdoid tumor of a 1 year old female was found.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of bladder neoplasms in the young population of Saudi Arabia

et al. 2017

View full text Add to dashboard Cite

Context:Bladder neoplasms are a well-studied subject in medicine. However, the evidence of bladder neoplasms in children and the young adult population (≤40 years), particularly in Saudi Arabia, is lacking.Aims:The aims of this study were to identify histopathological characteristics as well as clinical features, prognosis, and treatment of bladder neoplasms in this age group in a single tertiary referral center, Riyadh, Saudi Arabia.Settings and Design:A retrospective cohort study.Materials and Methods:Children and young adults (≤40 years) diagnosed with epithelial and mesenchymal bladder neoplasms from 1994 to 2017.Statistical Analysis Used:Descriptive data are presented as mean (standard deviation) or median (interquartile range) for continuous variables and n (%) for categorical variables. Statistical Package for Social Sciences version 23 was used.Results:Thirty-eight cases were identified. The majority, 71.1% (n = 27) were male. The median age of diagnosis was 33 years ranging from 1 to 40 years. Nearly 45% (n = 17) were smokers. Macroscopic hematuria was present in 57.8% (n = 22). The most common histopathology was papillary urothelial carcinoma (n = 18, 58%). All mesenchymal neoplasms accounted for 18.4% (n = 7). Of all malignancies, 63.2% (n = 24) and 44.7% (n = 17) were low stage and low grade, respectively. Transurethral resection of bladder tumor (TURBT) was conducted for 81.6% (n = 31). The mean length of follow-up was 36.05 months (±39.4 months). Recurrence occurred in 15.8% (n = 6) and 7.9% (n = 3) had progression. Distant metastasis was reported in 5.3% (n = 2). Nearly 8% (n = 3) died during their follow-up.Conclusions:Bladder malignancies at the early fourth decade of life tend to be a low stage and low grade. The most common histopathology was papillary urothelial carcinoma. Management should be based on the clinical and histopathological features. However, most of the patient underwent TURBT.

show abstract

Extraskeletal myxoid chondrosarcoma of the penis: Description of a rare tumor arising in an unusual location

Murshed

Darayseh²,

Kambal³

et al. 2022

Urology Case Reports

View full text Add to dashboard Cite

Myxoid chondrosarcoma of the scrotum: a case report and review of the literature

Cited by 6 publications

References 11 publications

Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases

Clinical and radiologic features of extraskeletal myxoid chondrosarcoma including initial presentation, local recurrence, and metastases

Characteristics of bladder neoplasms in the young population of Saudi Arabia

Extraskeletal myxoid chondrosarcoma of the penis: Description of a rare tumor arising in an unusual location

Contact Info

Product

Resources

About