Myxofibrosarcoma

Mentzel, Thomas; Calonje, Eduardo; Wadden, Catherine; Camplejohn, Richard S.; Beham, Alfred; Smith, Michael A.; Fletcher, Christopher D.�M.

doi:10.1097/00000478-199604000-00001

Cited by 473 publications

(154 citation statements)

References 31 publications

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“…It is usually composed of a variety of spindled, pleomorphic, or sometimes focally epithelioid cells with variable mitotic activity [2]. This tumor constitutes a distinct clinicopathologic entity [5] included in the WHO classification of soft tissue tumors [8]. While MFSs of the visceral organs are uncommon, they have been reported to occur in the heart, the aorta, the thyroid gland, and the brain [2].…”

Section: Discussionmentioning

confidence: 99%

“…While MFSs of the visceral organs are uncommon, they have been reported to occur in the heart, the aorta, the thyroid gland, and the brain [2]. Urological MFS tumors of the penis, spermatic cord, kidneys, and prostate are also rare, and less than 30 cases have been reported in the period between 1970 and 2000 [1,5,[7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…While leiomyosarcoma is the most common renal mesenchymal malignancy [2,3], osteosarcoma, angiosarcoma, rhabdomyosarcoma, synovial sarcoma, pleomorphic undifferentiated sarcoma, and fibrosarcoma are also prevalent. Retroperitoneal myxofibrosarcoma (MFS), especially of renal origin, is a more uncommon soft tissue tumor of the elderly [4], seen in less than 3% of all renal neoplasms [5]. It was previously known as the myxoid variant of malignant fibrous histiocytoma [6], and is regarded as a malignant fibroblastic lesion with variable myxoid stroma.…”

Section: Introductionmentioning

confidence: 99%

“…Histologically, MFS can be classified into three grades according to the grading system of the French Federation of Cancer Centers Sarcoma group (FNCLCC) [7]. Intermediate grade (grade 2) and high-grade (grade 3) neoplasms have a local recurrence rate of over 50%, and display high metastatic potential [5]. Primary MFS of the retroperitoneum is very rare, since this type of tumor is usually detected in the extremities of elderly patients.…”

Section: Introductionmentioning

confidence: 99%

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Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Kim¹,

Suh²,

Kim³

et al. 2017

J Cytol Histol

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A 45-year-old previously healthy woman presented to our hospital with a right abdominal mass. Abdominal computed tomography (CT), magnetic resonance imaging, and bone scanning revealed a 15 cm×10 cm×14 cm, well-delineated, retroperitoneal tumor originating from the right kidney. No metastases detected. The patient underwent successful extirpation of the renal tumor. The tumor showed 50% necrosis without perirenal fat infiltration, and it was diagnosed as a high-grade (grade 3) myxofibrosarcoma without nodal positivity, according to the French Federation of Cancer Centers Sarcoma (FNCLCC) grading system. Tumor immunohistochemical staining revealed positive staining for CD34, Ki67, smooth muscle actin (SMA), and cluster of differentiation 68 (CD68), and negative staining for S100 protein, desmin, mast/stem cell growth factor receptor (c-kit), and melanoma marker antibody (HMB45). Three months post-surgery, follow-up CT revealed no new abdominal metastasis, and the patient is currently receiving routine follow-up without any additional systemic therapy. Myxofibrosarcoma of the kidney is an uncommon soft tissue tumor, and radical surgery is the treatment of choice. Long-term follow-up is recommended because of the tumor's aggressive invasiveness and potential for distant metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Kim¹,

Suh²,

Kim³

et al. 2017

J Cytol Histol

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“…MFS also portends a better prognosis than the variants of MFH [4,5,6,7]. MFS classically presents superficially in the lower extremities, followed by the trunk, upper extremities, neck, and head [1,8,9,10], but it has also been reported superficially in the breast [11,12], perineum [13], and orbit [14,15]. Reports also exist of MFS in deep sites, including the esophagus [16], hypopharynx [17], vocal fold [18], parotid [19], heart [20,21,22], aorta [23], pulmonary artery [24], lung [25] and brain [26,27].…”

Section: Introductionmentioning

confidence: 99%

Myxofibrosarcoma: Cytomorphologic Findings and Differential Diagnosis on Fine Needle Aspiration

Olson¹,

Ali²

2012

Acta Cytologica

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Objective: To analyze the cytomorphologic findings of myxofibrosarcoma (MFS) on fine needle aspiration (FNA) and examine the differential diagnoses. Study Design: A retrospective review was undertaken of material from 22 patients with an FNA procedure of their tumor prior to resection. A tally was performed of all the features known in the literature, including myxoid matrix, spindle cells, nuclear pleomorphism, curvilinear vessels, and multinucleated cells. A review of the literature was also performed to elucidate any advances in the use of morphology and other modalities to deconvolute the challenging differential diagnosis. Clinicoradiologic characteristics and immunostaining were also analyzed and correlated. Results: FNA diagnoses included high-grade sarcoma (32%), recurrent MFS (23%), spindle cell neoplasm (18%), indeterminate-grade sarcoma (14%), low-grade sarcoma (9%), and pleomorphic adenoma (4%). Of the cases available for morphologic review, myxoid matrix was the most frequent observation (88%), followed by spindle cells (82%), nuclear pleomorphism (76%), multinucleated cells (71%), and curvilinear vessels (65%). Myxoid matrix, spindle cells, and nuclear pleomorphism were very often concomitant observations. Conclusion: MFS demonstrates characteristic albeit nonspecific morphological findings and can overlap morphologically with other clinically significant entities based on FNA material.

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Low grade fibromyxoid sarcoma

Lindberg¹,

Maitra²,

Gokaslan³

et al. 1999

Cancer

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BACKGROUND Although the histologic features of the recently described low grade fibromyxoid sarcoma are well established, to the authors' knowledge there are no reports in the literature describing the cytologic features of this tumor by fine‐needle aspiration. Recognition of this lesion is important because of its indolent but metastasizing nature. METHODS The authors retrospectively reviewed their surgical pathology files for cases of low grade fibromyxoid sarcoma with a preoperative fine‐needle aspiration biopsy (FNAB); three such cases were found. Immunohistochemical studies were performed in all three tumors, ultrastructural examination was performed in two tumors, and fresh tissue for cytogenetic analysis was obtained in one tumor. RESULTS All FNABs showed similar features. The aspirates were relatively hypocellular with an abundant myxoid background; the neoplastic cells contained oval to spindle shaped nuclei with minimal pleomorphism. No capillaries or areas of fibrous tissue were identified. Cytogenetic study of one case revealed no chromosomal abnormalities. The histologic findings were characteristic for this lesion. By immunohistochemistry the tumor cells showed diffuse and strong reactivity for vimentin only; at the ultrastructural level the neoplastic spindle cells had characteristics of fibroblasts. CONCLUSIONS The cytologic features of low grade fibromyxoid sarcoma are not specific enough for a definitive diagnosis based on FNAB alone; however, correlating the cytologic and clinical findings can narrow the range of diagnosis. The differential diagnosis includes other myxoid lesions, in particular superficial or intramuscular myxoma and myxofibrosarcoma. In addition, the immunohistochemical and ultrastructural findings support a fibroblastic origin for this neoplasm. Cancer (Cancer Cytopathol) 1999;87:75–82. © 1999 American Cancer Society.

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Myxofibrosarcoma

Cited by 473 publications

References 31 publications

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Myxofibrosarcoma: Cytomorphologic Findings and Differential Diagnosis on Fine Needle Aspiration

Low grade fibromyxoid sarcoma

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