Mythendämmerung

Frank, Manfred

doi:10.30965/9783846744390

Cited by 8 publications

(12 citation statements)

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“…However, coupled with uncertainties, the farm investment decisions are constrained by the personality traits, preferences, and competences [57]. One of the often cited personality traits that distinguish farmers in decision-making is risk perception [58,59]. If we view a farmer as an entrepreneur, the logic also follows that proactiveness and innovativeness additionally influence farmers' decisions [25].…”

Section: Farmer Entrepreneurshipmentioning

confidence: 99%

Determinants of Farm Resilience to Climate Change: The Role of Farmer Entrepreneurship and Value Chain Collaborations

2020

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The concept of resilience gained traction in academic, policy, and development discourse in recent years, yet its conceptualization and application at the farm level has received little attention. For instance, recent policy recommendations present farm resilience as a silver bullet in dealing with agricultural risks and uncertainty, and in achieving sustainable agri-food systems. Yet, the question of what determines farm resilience in a smallholder farming set-up remains fuzzy. To address this knowledge gap, we firstly develop a novel conceptual framework based on determinants of farm resilience and farmer adaptive capacity as a pathway through which farm resilience is strengthened. The emphasis on adaptive capacity responds to a conceptual weakness inherent in studies that present socio-ecological systems as static systems. Secondly, based on a literature review, we propose mechanisms through which farmer entrepreneurship, membership in farmer organization, and farmer–buyer relationships may influence farmer adaptive capacity and thereby farm resilience. Based on our conceptual understanding of the determinants of farm resilience, we recommend approaches that augment farmer entrepreneurship, support farmer organizations, and strengthen farmer–buyer relationships.

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Section: Farmer Entrepreneurshipmentioning

confidence: 99%

Determinants of Farm Resilience to Climate Change: The Role of Farmer Entrepreneurship and Value Chain Collaborations

2020

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“…Finally, IspH converts HMBPP to IPP and DMAPP, the isomeric C 5 precursors of isoprenoids. [41][42][43][44] Most of these enzymes play an essential role in MEP biosynthesis. 43 While each of the seven enzymes has potential as a drug target, [42][43]45 many of the enzymes present particular challenges with respect to inhibitor design and drug discovery.…”

Section: Introductionmentioning

confidence: 99%

“…[41][42][43][44] Most of these enzymes play an essential role in MEP biosynthesis. 43 While each of the seven enzymes has potential as a drug target, [42][43]45 many of the enzymes present particular challenges with respect to inhibitor design and drug discovery. Despite reported crystal structures, [46][47] demonstrated essentiality, 43 and initial inhibitors, 45 IspD and IspE suffer from other obstacles.…”

Section: Introductionmentioning

confidence: 99%

“…43 While each of the seven enzymes has potential as a drug target, [42][43]45 many of the enzymes present particular challenges with respect to inhibitor design and drug discovery. Despite reported crystal structures, [46][47] demonstrated essentiality, 43 and initial inhibitors, 45 IspD and IspE suffer from other obstacles. The active site of IspD is very flexible, highly polar, and lies at a dimer interface.…”

Section: Introductionmentioning

confidence: 99%

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The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

Wang

Dowd

2018

ACS Infect. Dis.

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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a severe infectious disease in need of new chemotherapies especially for drug-resistant cases. To meet the urgent requirement of new TB drugs with novel modes of action, the TB research community has been validating numerous targets from several biosynthetic pathways. The methylerythritol phosphate (MEP) pathway is utilized by Mtb for the biosynthesis of isopentenyl pyrophosphate (IPP) and its isomer dimethylallyl pyrophosphate (DMAPP), the universal five-carbon building blocks of isoprenoids. While being a common biosynthetic pathway in pathogens, the MEP pathway is completely absent in humans. Due to its unique presence in pathogens as well as the essentiality of the MEP pathway in Mtb, the enzymes in this pathway are promising targets for the development of new drugs against tuberculosis. In this Review, we discuss three enzymes in the MEP pathway: 1-deoxy-d-xylulose-5-phosphate synthase (DXS), 1-deoxy-d-xylulose-5-phosphate reductoisomerase (IspC/DXR), and 2 C-methyl-d-erythritol 2,4-cyclodiphosphate synthase (IspF), which appear to be the most promising antitubercular drug targets. Structural and mechanistic features of these enzymes are reviewed, as well as selected inhibitors that show promise as antitubercular agents.

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“…In Hamm, the children of the Jewish school provided music for the community's worship services. 52 [61][62]. Though he normally annotated his many clever literary and artistic references, Berger failed to provide a footnote explaining his use of the term "Sommer-Reise" ("summer journey").…”

Section: Jewish Childhood In Hammmentioning

confidence: 99%

Jean Berger's staged choruses as a concurrence of biographical and artistic reinvention

Schnack¹

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Mythendämmerung

Cited by 8 publications

References 0 publications

Determinants of Farm Resilience to Climate Change: The Role of Farmer Entrepreneurship and Value Chain Collaborations

Determinants of Farm Resilience to Climate Change: The Role of Farmer Entrepreneurship and Value Chain Collaborations

The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis

Jean Berger's staged choruses as a concurrence of biographical and artistic reinvention

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