Mystical compositions of the self

Hutchinson-Reuss, Cory Bysshe

doi:10.17077/etd.hiaazb0b

Cited by 3 publications

(5 citation statements)

References 22 publications

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“…In fact, it has been known for more than 30 years that, by incorporating a low molecular weight PLGA into the polymer matrix at elevated drug loading, continuous release of polypeptides is commonly observed without an induction time before polymer mass loss (should the polypeptide remain soluble) [13]. There are also PLGA products that release highly water-soluble peptides without a significant burst release [14].…”

Section: Evaluation Of Key Plga Concepts To Identify Issues In Depmentioning

confidence: 99%

“…Hutchinson showed that continuous peptide and protein release could be accomplished by including a significant or whole fraction of PLGA having reduced molecular weight [13]. Increased drug loading also was found to be beneficial.…”

Section: Evaluation Of Key Plga Concepts To Identify Issues In Depmentioning

confidence: 99%

“…Low MW PLGA typically contains oligomers of the polymer that have limited water solubility to trigger polymer erosion, and upon hydrolysis generates a continuous supply of polymer chains in the ∼1 kD range or less [22]. The continuous in vitro release of peptide from low MW PLGA films by erosion control was also found to be mostly independent of film thickness [13]. …”

Section: Evaluation Of Key Plga Concepts To Identify Issues In Depmentioning

confidence: 99%

“…With the advent of microsphere size control, as described above by direct control of emulsion size or with lower yields (without the API) by tightly controlling size between screen sizes according to the aqueous encapsulation paradigm, the prospect of improving needles for patients is highly intriguing. Keep in mind that this can usually be done without large changes to long-term polypeptide release if the Hutchinson [13] approach to continuous release is used, which is not expected to be strongly influenced by microsphere size.…”

Section: Approaches To Overcome Issues Impeding Depot Developmentmentioning

confidence: 99%

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Injectable controlled release depots for large molecules

Schwendeman

Shah

Bailey

et al. 2014

Journal of Controlled Release

171

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Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen highly successful pharmaceutical products. Until now, success has been limited to several small molecules and peptides, although remarkable improvements have been accomplished in some of these cases. For example, twice-a-year depot injections with leuprolide are available compared to the once-a-day injection of the solution dosage form. Injectable depots are typically prepared by encapsulation of the drug in poly(lactic-co-glycolic acid) (PLGA), a polymer that is used in children every day as a resorbable suture material, and therefore, highly biocompatible. PLGAs remain today as one of the few “real world” biodegradable synthetic biomaterials used in US FDA-approved parenteral long-acting-release (LAR) products. Despite their success, there remain critical barriers to the more widespread use of PLGA LAR products, particularly for delivery of more peptides and other large molecular drugs, namely proteins. In this review, we describe key concepts in the development of injectable PLGA controlled-release depots for peptides and proteins, and then use this information to identify key issues impeding greater widespread use of PLGA depots for this class of drugs. Finally, we examine important approaches, particularly those developed in our research laboratory, toward overcoming these barriers to advance commercial LAR development.

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Section: Evaluation Of Key Plga Concepts To Identify Issues In Depmentioning

confidence: 99%

Section: Evaluation Of Key Plga Concepts To Identify Issues In Depmentioning

confidence: 99%

Section: Evaluation Of Key Plga Concepts To Identify Issues In Depmentioning

confidence: 99%

Section: Approaches To Overcome Issues Impeding Depot Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Injectable controlled release depots for large molecules

Schwendeman

Shah

Bailey

et al. 2014

Journal of Controlled Release

171

View full text Add to dashboard Cite

show abstract

“…However, Curry and Kasser, citing Belchamber, recommend that individuals color mandalas, which refer to "symmetrical figures that have long been used as meditative objects in spiritual traditions" [2]. Hutchinson explains that a mandala is a name that is derived from the Sanskrit word circle, and the concept denotes a Hindu and Buddhist symbol that stands for the universe and its energy [3]. Elkis-Abuhoff also makes the same point, but the author clarifies that the word stands for both center and circle [4].…”

Section: Introductionmentioning

confidence: 99%

A new method for mandala image synthesis based on WGAN-GP

Cao

Lin

et al. 2023

ACE

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Mandala, as an ancient image art, has been found to have many unexpected applications in recent years, including use in art therapies, meditation induction and human body state assessment. Despite the omnipresent applications of convolutional neural networks in imaging Synthesis, it can be found that there is no work on Mandala Image Synthesis yet. To fill this research gap, deep learning algorithms were considered in this study. With existing research on Generative Adversarial Network (GAN), a typical GAN network called WGAN-GP was used to produce Mandala images. The generator and discriminators in the WGAN-GP network are fully trained in this study. To prove the robustness of the employed method, this study also investigates and compares the performances of WGAN-GP and other GANs. The experimental results demonstrated the effectiveness and satisfactory performance of the employed method. In brief, our completed work can effectively help provide Mandala images for further research on it.

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‘Shrink Not Appalled from My Great Sorrow’: Translating Emotion in the Celtic Revival

Mathis

2023

Emotional Alterity in the Medieval North Sea World

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Mystical compositions of the self

Abstract: Mystical Compositions of the Self: Women, Modernism, and Empire explores women's early 20 th-century literary inscriptions of mysticism's entanglement with empire and the figure of the female at the center of each. Through an examination of selected texts by

Cited by 3 publications

References 22 publications

Injectable controlled release depots for large molecules

Injectable controlled release depots for large molecules

A new method for mandala image synthesis based on WGAN-GP

‘Shrink Not Appalled from My Great Sorrow’: Translating Emotion in the Celtic Revival

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