Mysterious but not serious?

Hann, G; Thust, Stefanie; Devereux, Emma

doi:10.1136/bcr.08.2011.4726

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…The most common overlap syndrome in which OPK combined with other osteosclerotic disorders is a combination of melorheostosis, OPK, and osteopathia striata (type 1) [ 11 ]. Complications of OPK are rare, but cases of osteosarcoma, chondrosarcoma, and giant cell tumor have been reported although no definite association has been established [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Case Report of Osteopoikilosis: Sparse Cause of Bone Pain and Mimicker of Metastasis on Radiographs

Panchal¹,

Gawhale²,

Shah³

et al. 2021

JOCR

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Introduction: Osteopoikilosis (OPK) is an extremely rare benign condition with autosomal dominant inheritance characterized by sclerosing bony dysplasia with multiple benign enostoses. It is characterized by symmetrically distributed numerous, small, well-defined, homogenous circular or ovoid radiodensities clustered in epiphysis and metaphysis of long bones in periarticular region, and in some cases diffusely present throughout axial and appendicular skeleton. There is no age and sex predilection; age at the time of diagnosis ranges from 15 to 60 years. It is usually asymptomatic but rarely in 15–20% patients slight juxta-articular pain and joint effusions can be seen. These are incidental radiological findings in most of the cases, also sometimes confused as bony metastasis. There are no specific clinical features; histological features are similar to bony island and it may be associated with connective tissue disorders, synovial osteochondromatosis, and a rare bone condition melorheostosis. Case Report: We present a case of OPK in a 32-year-old male with bilateral hip and shoulder pain, based on the available literature and focus on clinical significance, due to its mimicking capability of other more severe conditions such as bone metastases and an extremely uncommon cause of bone pain. Conclusion: OPK is an uncommon hereditary condition involving juxta-articular region of long bones with intricate etiopathogenesis, often discovered incidentally on radiographs. It is characterized by multiple, symmetrical ovoid radiodensities, and in most instances confused with osteoblastic metastasis. This concludes that OPK is a condition that should be kept in mind to avoid misdiagnosis, in particular osteoblastic metastasis and undue distress to both the patients and doctors. Keywords: Osteopoikilosis, melorheostosis, bone metastases

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Section: Discussionmentioning

confidence: 99%