Mysids in toxicity testing - a review

Nimmo, Del Wayne R.; Hamaker, T. L.

doi:10.1007/978-94-009-8012-9_18

Cited by 31 publications

(27 citation statements)

References 15 publications

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“…Literature regarding toxicity testing with the standard mysid species A. bahia demonstrates the high sensitivity of mysids, in many cases at levels that are likely to occur in the environment [24,44,45]. The acute LC50 for juvenile N. integer of 164 ng/L of TBTCl found in this study is lower than that reported by Goodman et al [46] for A. bahia (1,100 ng/L of TBT).…”

Section: Acute Toxicity Of Tbtcl To N Integercontrasting

confidence: 58%

Testosterone Metabolism in the Estuarine Mysid Neomysis Integer (Crustacea; Mysidacea) Following Tributyltin Exposure

Verslycke¹,

Poelmans²,

Wasch³

et al. 2003

Environ Toxicol Chem

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Current evidence suggests that the biocide tributyltin (TBT) causes the development of imposex, a state of pseudohermaphrodism in which females exhibit functional secondary male characteristics, by altering the biotransformation or elimination of testosterone. Imposex in gastropods following TBT exposure is the most complete example of the effects of an endocrine disrupter on marine invertebrates. Previous studies have demonstrated that the estuarine mysid Neomysis integer converts testosterone into multiple polar and nonpolar metabolites resulting from both phase I and phase II biotransformations. In this study, the effects of TBT chloride (TBTCl) on the phase I and II testosterone metabolism of N. integer were evaluated. The TBTCl was highly toxic to N. integer (96-h median lethal concentration [LC50] of 164 ng/L). To assess the effects on testosterone metabolism, mysids were exposed for 96 h to different concentrations of TBTCl (control, 10, 100, and 1,000 ng/L), and testosterone elimination as polar hydroxylated, nonpolar oxido-reduced, and glucose- and sulfate-conjugated metabolites was examined. The TBTCl differentially affected testosterone metabolism. The effect of TBTCl on phase I metabolism was unclear and has been shown to vary among species, likely depending on the inducibility or presence of certain P450 isozyme families. Reductase activity and metabolic androgenization were induced in the 10-ng/L treatment, whereas higher concentrations resulted in a reduction of sulfate conjugation. The exact mechanisms underlying TBT-induced imposex and alterations in the steroid metabolism need to be further elucidated.

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Section: Acute Toxicity Of Tbtcl To N Integercontrasting

confidence: 58%

Testosterone Metabolism in the Estuarine Mysid Neomysis Integer (Crustacea; Mysidacea) Following Tributyltin Exposure

Verslycke¹,

Poelmans²,

Wasch³

et al. 2003

Environ Toxicol Chem

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“…Responses of growth and reproduction in toxicity tests typically covary (Breteler et al, 1982;Nimmo and Hamaker, 1982). In this study, proportional reductions in gravid females at any treatment were greater than those in weight, suggesting that reproductive measures are a more sensitive indicator than those for growth.…”

Section: Toxicity Testsmentioning

confidence: 53%

“…The ERS WSF had sublethal effects on weight and reproduction which can have important ecological consequences (Nimmo and Hamaker, 1982). Dry weight gain and molt frequency are measures of somatic growth, whereas the proportion of egg-bearing females is an indicator of reproductive health.…”

Section: Toxicity Testsmentioning

confidence: 99%

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Toxicity of Creosote Water-Soluble Fractions Generated from Contaminated Sediments to the Bay Mysid

Padma

Hale

Roberts

et al. 1999

Ecotoxicology and Environmental Safety

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“…The mysid shrimp, Americamysis bahia, is considered a primary candidate for monitoring the health of estuarine habitats [1] and has been adopted as a standard marine and estuarine test organism by the U.S. Environmental Protection Agency (U.S. EPA) [2]. Americamysis bahia is more sensitive to toxic substances than many other marine species [3,4] and has been used to demonstrate the toxicity of heavy metals [5][6][7] and pesticides [8][9][10] on the physiological and individual levels.…”

Section: Introductionmentioning

confidence: 99%

Projected population‐level effects of thiobencarb exposure on the mysid, Americamysis bahia, and extinction probability in a concentration‐decay exposure system

Raimondo

McKenney

2005

Enviro Toxic and Chemistry

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Population-level effects of the mysid, Americamysis bahia, exposed to varying thiobencarb concentrations were estimated using stage-structured matrix models. A deterministic density-independent matrix model estimated the decrease in population growth rate (lambda) with increasing thiobencarb concentration. An elasticity analysis determined that survival of middle stages provided the largest contribution to lambda. Decomposing the effects of lambda in terms of changes in the matrix components determined that reduced reproduction had a large influence on population dynamics at lower thiobencarb concentrations, whereas reduced survivorship had the largest impact on populations at higher concentrations. A simulation model of a concentration-decay system was developed to demonstrate the importance of integrating chemical half-life and management practices in determining population viability. In this model, mysids were originally exposed to a high thiobencarb concentration (300 microg/L) that decayed an order of magnitude in the number of mysid generations corresponding to thiobencarb half-life values under three different exposure regimes. Environmental stochasticity was added to the model to estimate the cumulative extinction probability of mysids exposed to fluctuating concentrations of thiobencarb in random environments. The cumulative extinction probability increased with thiobencarb half-life, stochasticity, and concentration present at the time of a new exposure. The model demonstrated the expansion of population projection models in determining the ecological impact of a population exposed to pesticides.

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Mysids in toxicity testing - a review

Cited by 31 publications

References 15 publications

Testosterone Metabolism in the Estuarine Mysid Neomysis Integer (Crustacea; Mysidacea) Following Tributyltin Exposure

Testosterone Metabolism in the Estuarine Mysid Neomysis Integer (Crustacea; Mysidacea) Following Tributyltin Exposure

Toxicity of Creosote Water-Soluble Fractions Generated from Contaminated Sediments to the Bay Mysid

Projected population‐level effects of thiobencarb exposure on the mysid, Americamysis bahia, and extinction probability in a concentration‐decay exposure system

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