Mysids in toxicity testing ? a review

Nimmo, Del Wayne R.; Hamaker, T. L.

doi:10.1007/bf00008110

Cited by 60 publications

(22 citation statements)

References 15 publications

(16 reference statements)

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“…Mysids are also frequently used in toxicity testing (e.g. Nimmo and Hamaker, 1982;USEPA, 1995USEPA, , 1997ASTM, 1998ASTM, , 1999Roast et al, 1998;Verslycke et al, 2003b) and are sensitive to many toxicants at levels that are likely to occur in the environment (Roast et al, 1998;Verslycke et al, 2003b). We have been using the hyperbenthic mysid Neomysis integer as a test organism for the evaluation of the endocrine-disruptive properties of chemicals in the laboratory and the Scheldt estuary (for a review on the use of mysids as potential test organisms for the evaluation of environmental endocrine disruption, refer to Verslycke et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Flame retardants, surfactants and organotins in sediment and mysid shrimp of the Scheldt estuary (The Netherlands)

Verslycke

Vethaak²,

Arijs

et al. 2005

Environmental Pollution

128

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Abstract. Sediment and mysids from the Scheldt estuary, one of the largest and most polluted estuaries in Western Europe, were analyzed for a number of contaminants that have shown to possess endocrine-disrupting activity, i.e. organotins, polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBPA), nonylphenol ethoxylates (NPE) and transformation products nonylphenol (NP) and nonylphenol ether carboxylates (NPEC). In addition, in vitro estrogenic and androgenic potencies of water and sediment extracts were determined. Total organotin concentrations ranged from 84 to 348 ng/g dw in sediment and 1110 to 1370 ng/g dw in mysid. Total PBDE (excluding BDE-209) concentrations ranged from 14 to 22 ng/g dw in sediment and from 1765 to 2962 ng/g lipid in mysid. High concentrations of BDE-209 (240-1650 ng/g dw) were detected in sediment and mysid (269-600 ng/g lipid). Total HBCD concentrations in sediment and mysid were 14-71 ng/g dw and 562-727 ng/g lipid, respectively. Total NPE concentrations in sediment were 1422 ng/g dw, 1222 ng/g dw for NP and 80 ng/g dw for NPEC and ranged from 430 to 1119 ng/g dw for total NPE and from 206 to 435 ng/g dw for NP in mysid. Significant estrogenic potency, as analyzed using the yeast estrogen assay, was detected in sediment and water samples from the Scheldt estuary, but no androgenic activity was found. This study is the first to report high levels of endocrine disruptors in estuarine mysids.Capsule. Field populations of mysid shrimp (Neomysis integer) of the Scheldt estuary (The Netherlands) are exposed to high concentrations of endocrine disruptors.

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Section: Introductionmentioning

confidence: 99%

Flame retardants, surfactants and organotins in sediment and mysid shrimp of the Scheldt estuary (The Netherlands)

Verslycke

Vethaak²,

Arijs

et al. 2005

Environmental Pollution

128

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“…Still, the toxicity and repellence of M. spicatum to mysids and sticklebacks seems surprising because none of these species feed on aquatic macrophytes (Mauchline 1980;Hangelin and Vuorinen 1988), and they should, therefore, not be targets of antiherbivore substances. On the other hand, mysids are very sensitive to chemical contaminants such as trace metals and pesticides (Nimmo and Hamaker 1982;Roast et al 1998) and may therefore be sensitive to natural toxins as well. Sublethal contaminant concentrations suppress swimming and feeding activity of mysids (Nimmo and Hamaker 1982) and interrupt swarming (Roast et al 1998), which is an efficient predator avoidance strategy (Flynn and Ritz 1999).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, mysids are very sensitive to chemical contaminants such as trace metals and pesticides (Nimmo and Hamaker 1982;Roast et al 1998) and may therefore be sensitive to natural toxins as well. Sublethal contaminant concentrations suppress swimming and feeding activity of mysids (Nimmo and Hamaker 1982) and interrupt swarming (Roast et al 1998), which is an efficient predator avoidance strategy (Flynn and Ritz 1999). Notably, in the lower vegetation to water ratio of our behavior experiments the toxin concentration was too low to induce mortality but high enough to induce behavioral responses in N. integer as well as stickleback larvae.…”

Section: Discussionmentioning

confidence: 99%

The lethal and sublethal effects of the aquatic macrophyte Myriophyllum spicatum on Baltic littoral planktivores

Lindén

Lehtiniemi

2005

Limnol. Oceanogr.

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Macrophyte architecture can structure predator-prey interactions, but it is the chemicals within the plant that may actually be lethal. We conducted aquarium experiments to study the effects of common aquatic macrophytes (Myriophyllum spicatum, Myriophyllum sibiricum, and Chara tomentosa) and a predator (perch, Perca fluviatilis) on the survival, habitat choice, swimming, and feeding activities of Baltic littoral planktivores, mysids Neomysis integer and Praunus flexuosus, and three-spined stickleback (Gasterosteus aculeatus) larvae. Chemicals excreted by M. spicatum in a dense patch caused high mortality (73% to 89%) in both mysid species but not in sticklebacks, whereas M. sibiricum and C. tomentosa had no lethal effects. In lower stem densities stickleback larvae and N. integer avoided M. spicatum even in the presence of predator signals, and M. spicatum lowered the swimming and feeding activities of stickleback larvae. Only P. flexuosus did not avoid M. spicatum vegetation. Areas occupied by M. spicatum seem to be highly unsuitable habitats for littoral mysids and three-spined stickleback larvae. Because M. spicatum is a dominant macrophyte in the study area and eutrophication further increases its abundance, it may strongly influence the occurrence and distribution of mysids and fish larvae in the littoral ecosystems of the Baltic Sea.

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“…Mysids have been used in (regulatory) toxicity testing for more than two decades (Nimmo and Hamaker, 1982;Verslycke et al, 2004a). USEPA (US Environmental Protection Agency) and ASTM (American Society for Testing of Materials) have adopted the sub-tropical Americamysis (formerly Mysidopsis) bahia as a key testing species for coastal and estuarine monitoring, and standard guidelines for life-cycle toxicity testing with this species have been developed (USEPA, 1997(USEPA, , 2002bASTM, 1999;OECD, 2006).…”

Section: Mysids In Standard Toxicity Testing and Preferred Species Fomentioning

confidence: 99%

Mysid crustaceans as standard models for the screening and testing of endocrine-disrupting chemicals

et al. 2007

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Investigative efforts into the potential endocrine-disrupting effects of chemicals have mainly concentrated on vertebrates, with significantly less attention paid to understanding potential endocrine disruption in the invertebrates. Given that invertebrates account for at least 95% of all known animal species and are critical to ecosystem structure and function, it remains essential to close this gap in knowledge and research. The lack of progress regarding endocrine disruption in invertebrates is still largely due to: (1) our ignorance of mode-of-action, physiological control, and hormone structure and function in invertebrates; (2) lack of a standardized invertebrate assay; (3) the irrelevance to most invertebrates of the proposed activity-based biological indicators for endocrine disruptor exposure (androgen, estrogen and thyroid); (4) limited field studies. Past and ongoing research efforts using the standard invertebrate toxicity test model, the mysid shrimp, have aimed at addressing some of these issues. The present review serves as an update to a previous publication on the use of mysid shrimp for the evaluation of endocrine disruptors (Verslycke et al., 2004a). It summarizes recent investigative efforts that have significantly advanced our understanding of invertebrate-specific endocrine toxicity, population modeling, field studies, and transgeneration standard test development using the mysid model.

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Mysids in toxicity testing ? a review

Cited by 60 publications

References 15 publications

Flame retardants, surfactants and organotins in sediment and mysid shrimp of the Scheldt estuary (The Netherlands)

Flame retardants, surfactants and organotins in sediment and mysid shrimp of the Scheldt estuary (The Netherlands)

The lethal and sublethal effects of the aquatic macrophyte Myriophyllum spicatum on Baltic littoral planktivores

Mysid crustaceans as standard models for the screening and testing of endocrine-disrupting chemicals

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