Myrtus communis L. (Myrtle) plant parts: Comparative assessment of their chemical compositions and antioxidant, anticancer, and antimutagenic activities

Güzelmeriç, Etil; Ugurlu, Pırıl; Celik, Cansel; Sen, Nisa Beril; Helvacıoğlu, Sinem; Charehsaz, Mohammad; Erdoğan, Murat; Oçkun, Mehmet Ali; Kırmızıbekmez, Hasan; Aydın, Ahmet; Yeşilada, Erdem

doi:10.1016/j.sajb.2022.07.043

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…The study presented by Guzelmeric et al [ 22 ], in which methanol was used as a solvent to extract the TPC of the whole plant (leaves, fruits, and flowers), also revealed an interesting capacity for M. communis L. to inhibit free radicals. In this study, in DPPH and ABTS assays, the authors showed an inhibiting capacity of the extract of 447.91 and 578.92 mg TE/g, respectively, and in the FRAP assay, they indicated a reducing activity of 257.27 mg TE/g.…”

Section: Resultsmentioning

confidence: 99%

“…On the contrary, ferulic acid showed the highest amount in MCLE40, which corresponded to ~20.61 mg/L. Guzelmeric et al [ 22 ] also reported the presence of myrcetin in the hydroalcoholic extract of M. communis L. (extract of leaves, flowers, and fruits) and demonstrated that the highest prevalence of this compound was found in the leaves (~25.01 mg/g in leaves), followed by the flowers (~11.14 mg/g) and the fruits (4.07 mg/g). Tuberoso et al [ 38 ] reported results on the phenolic composition of MCLE using three solvents (ethanol, water, and ethyl acetate).…”

Section: Resultsmentioning

confidence: 99%

“…They act by protecting lipids from oxidation initiators or hindering the propagation phase, known as chain-breaking antioxidants [ 21 ]. Myrtus communis L., also known as Myrtle and belonging to the Myrtaceae family, is an evergreen bush with an average height ranging from 1 to 5 m. This plant is naturally found, particularly flourishing in the Mediterranean region [ 22 , 23 ]. Various parts of the plant have found applications in the food (i.e., as flavorings) and cosmetic industries, as well as in traditional folk medicine.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the Incorporation of Myrtus communis L. Leaves Infusion in Alginate-Based Films and Spheres to Enhance the Oxidative Stability of Oil-in-Water Emulsions

El Hammadi,

Almajano,

Pastor

et al. 2024

Polymers

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Myrtus communis L. is a species of the Myrtaceae family that is found in the Mediterranean region, and it is traditionally recognized for its importance and different uses. The objective of this study was to determine the effect of M. communis L. leaf extract (MCLE), which was incorporated directly into alginate spheres and films, on preserving oil-in-water emulsions from oxidation. For this purpose, the solvent extraction (with ethanol at 40, 60, and 80%) of the antioxidant compounds was optimized (total phenolic compounds (TPCs) and total flavonoid content (TFC)) along with the scavenging activity. The best condition for the extraction corresponded with 60% ethanol (MCLE60), with a TPC of ~66.06 g GAE/L and a TFC of ~18.91 g QE/L, which was selected for use in the following assays. MCLE60 showed a considerable radical scavenging activity (24.85 mmol TE/L in FRAP, 28.75 mmol TE/L in DPPH, 30.61 mmol TE/L in ABTS, and 14.94 mmol TE/L in ORAC), which was probably due to its content in the phenolic compounds arbutin (122.08 mg/L), epicatechin (73.89 mg/L), sinapic acid (51.85 mg/L), and gallic acid (36.72 mg/L). The oil-in-water emulsions with the MCLE60 spheres showed the best oxidative stability (TBARS ~2.64 mg MDA/kg of emulsion, PV ~35.7 meq hydroperoxides/kg of emulsion) in comparison to the control. The film was also able to protect the emulsion from oxidation for more than a week at 30 °C (TBARS ~1.9 mg MDA/kg of emulsion). The alginate films with MCLE60 presented an important release of phenolic compounds in water and acetic food simulants, while in both ethanol simulants, the release of TPC remained more stable over time. Thus, this study highlights the potential uses of MCLE as a natural ingredient for emulsion oxidative preservation and the production of alginate delivery systems (spheres and films).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating the Incorporation of Myrtus communis L. Leaves Infusion in Alginate-Based Films and Spheres to Enhance the Oxidative Stability of Oil-in-Water Emulsions

El Hammadi,

Almajano,

Pastor

et al. 2024

Polymers

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“…The greatest impacts on antioxidant activity were observed for SDE after subjecting it to acid and basic hydrolysis, and these stresses caused the highest level of degradation in the myricitrin marker, indicating that this flavonoid, which already has antioxidant potential described in the literature (Domitrovic et al, 2015;Guzelmeric et al, 2022), plays an important role in the antioxidant activity of the species.…”

Section: Antioxidant Activitymentioning

confidence: 92%

Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

Santos

Lima

Machado

et al. 2023

Biomedical Chromatography

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The aim of this study is to demonstrate the stability‐indicating capacity of an analytical method for Eugenia uniflora, enhance understanding of the stability of myricitrin, and assess the effect of degradation of spray‐dried extract (SDE) on antioxidant and antifungal activities. Validation of the stability‐indicating method was carried out through a forced degradation study of SDE and standard myricitrin. The antioxidant and antifungal activities of SDE were evaluated both before and after degradation. The quantification method described was found to be both accurate and precise in measuring myricitrin levels in SDE from E. uniflora, with excellent selectivity that confirmed its stability‐indicating capability. The forced degradation study revealed that the marker myricitrin is sensitive to hydrolysis, but generally stable under other stress conditions. By contrast, the standard myricitrin displayed greater susceptibility to degradation under forced degradation conditions. Analysis of the antioxidant activity of SDE before and after degradation showed a negative impact in this activity due to degradation, while no significant effect was observed on antifungal activity. The method described can be a valuable tool in the quality control of E. uniflora, and the findings can assist in determining the optimal conditions and storage of products derived from this species.

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“…Dried flower-bearing branches, leaves, and freeze-dried fruits of Crataegus species were ground with a laboratory mill (Arcelik, K3104, İstanbul, Türkiye), then 5 g of powdered plant parts were extracted with 100 mL of 70% ethanol (aq) using an ultrasonic bath (Bandelin 156BH, Germany) for 30 min [ 41 ]. The solutions obtained were filtered with 0.2 mm thick filter paper (Macherey-Nagel, Düren, Germany), and then ethanol was evaporated by using a rotary evaporator (Heidolph, Schwabach, Germany) at 45 °C and 80 mbar pressure conditions.…”

Section: Methodsmentioning

confidence: 99%

Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species

Turnalar Ülger,

Oçkun,

Guzelmeric

et al. 2023

Molecules

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Crataegus turcicus is a plant endemic to Türkiye. For the first time, this study aimed to comparatively assess its flower-bearing branches, leaves, and fruits with other well-known Crataegus species (C. monogyna, C. pentagyna, and C. orientalis) in terms of chemical composition and bioactivity studies to evaluate its potential use as a food supplement. Firstly, the contents of total phenolics (TPC), flavonoids (TFC), proanthocyanidin (TPAC), and anthocyanin (TAC) in different plant parts of Crataegus species were evaluated. The highest TPAC was found in the hydroalcoholic extract of C. turcicus flower-bearing branches. Moreover, all plant parts had comparatively higher amounts of TPC, TFC, and TAC compared to other Crataegus species. The chemical screening by high-performance thin-layer chromatography (HPTLC) resulted that C. turcicus parts were rich with chlorogenic acid, neochlorogenic acid, quercetin and vitexin derivatives, epicatechin, procyanidin, etc., and their quantities were evaluated by high-performance liquid chromatography (HPLC). In terms of several in vitro antioxidant activity outcomes, the flower-bearing branches of C. turcicus showed the highest antioxidant activity by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) test among the assessed antioxidant assays. Additionally, hydroalcoholic extracts of C. turcicus significantly decreased LPS-induced nitric oxide, tumor necrosis factor-alpha, and interleukin-6 production more potently than indomethacin (positive control). In addition to its remarkable anti-inflammatory activity, C. turcicus showed analgesic activity by reducing prostaglandin E2 levels.

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Myrtus communis L. (Myrtle) plant parts: Comparative assessment of their chemical compositions and antioxidant, anticancer, and antimutagenic activities

Cited by 10 publications

References 23 publications

Evaluating the Incorporation of Myrtus communis L. Leaves Infusion in Alginate-Based Films and Spheres to Enhance the Oxidative Stability of Oil-in-Water Emulsions

Evaluating the Incorporation of Myrtus communis L. Leaves Infusion in Alginate-Based Films and Spheres to Enhance the Oxidative Stability of Oil-in-Water Emulsions

Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species

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