2015
DOI: 10.1007/s11418-015-0923-7
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Myrtucommulone-A treatment decreases pluripotency- and multipotency-associated marker expression in bladder cancer cell line HTB-9

Abstract: Cancer and stem cells exhibit similar features, including self-renewal, differentiation and immortality. The expression of stem-cell-related genes in cancer cells is demonstrated to be potentially correlated with cancer cell behaviour, affecting both drug response and tumor recurrence. There is an emerging body of evidence that subpopulations of tumors carry a distinct molecular sign and are selectively resistant to chemotherapy. Therefore, it is important to find novel therapeutic agents that could suppress t… Show more

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Cited by 16 publications
(14 citation statements)
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References 54 publications
(54 reference statements)
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“…found the treatment of MC‐A decreased cancer cell viability, proliferation and sphere‐forming ability in HTB‐9 cells, as well as the expression of common stem cell markers (e.g. NANOG, OCT4, SOX‐2, CD44) . Furthermore, they confirmed the functional inhibition of the EMT by MC‐A (thymoquinone was simultaneously analyzed) by testing the expression of EMT markers, and changes were found in the expression of proteins involved in the PI3K/AKT pathway; MC‐A and thymoquinone treatment inhibited the phosphorylation of those proteins in a context‐dependent manner .…”
Section: Emt‐related Markers and Pathwaysmentioning
confidence: 61%
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“…found the treatment of MC‐A decreased cancer cell viability, proliferation and sphere‐forming ability in HTB‐9 cells, as well as the expression of common stem cell markers (e.g. NANOG, OCT4, SOX‐2, CD44) . Furthermore, they confirmed the functional inhibition of the EMT by MC‐A (thymoquinone was simultaneously analyzed) by testing the expression of EMT markers, and changes were found in the expression of proteins involved in the PI3K/AKT pathway; MC‐A and thymoquinone treatment inhibited the phosphorylation of those proteins in a context‐dependent manner .…”
Section: Emt‐related Markers and Pathwaysmentioning
confidence: 61%
“…Numerous studies have confirmed the expression of CD44 in UCSCs. At present, CD44 – especially CD44v6 – is the most commonly used CSC marker …”
Section: Common Cdsmentioning
confidence: 99%
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“…SOX family of proteins are found in all metazoans, and high expression of SOX2 has been used to recognize the presence of CSCs. This approach has been applied in some studies of urothelial carcinoma [ 21 , 32 , 51 , 52 ].…”
Section: Sox4mentioning
confidence: 99%
“…Myrtucommulone-A (MC-A) is an active compound isolated from the leaves of myrtle [12]. Previously we have shown that MC-A-treatment decreased multipotency-associated marker expression in cancer cells [13] and shortterm MC-A-treatment reduced the cytokine expression in hMSCs [14]. In the present study we sought to determine the long-term effects of MC-A on the stemness of hMSCs and analysed the differentiation potential of hMSCs upon extended MC-A-treatment.…”
Section: Introductionmentioning
confidence: 99%