Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells

Martins, Célia; Doran, Carolina; Silva, Inês C.; Miranda, Cláudia C.; Rueff, José; Rodrigues, António Sebastião

doi:10.1016/j.cbi.2014.04.014

Cited by 39 publications

(25 citation statements)

References 46 publications

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“…The results demonstrated that myristicin may actually have some anxiogenic effect and may antagonize the actions of benzodiazepine, the GABA A receptors allosteric potentiators. In addition the CNS activity, antihelmintic, insecticidal, apoptotic, and protection against DNA damage effects were reported to myristicin (Du et al 2014, Lopez et al 2015, Martins et al 2014). However, most of these activities are scattered in the literature, with no systematic follow up studies that further corroborate the findings or carry them further to application.…”

Section: Pharmacological Evaluation Of Pure Nutmeg Compoundsmentioning

confidence: 99%

Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.)

Abourashed

El‐Alfy

2016

Phytochem Rev

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Nutmeg is a valued kitchen spice that has been used for centuries all over the world. In addition to its use in flavoring foods and beverages, nutmeg has been used in traditional remedies for stomach and kidney disorders. The antioxidant, antimicrobial and central nervous system effects of nutmeg have also been reported in literature. Nutmeg is a rich source of fixed and essential oil, triterpenes, and various types of phenolic compounds. Many of the secondary metabolites of nutmeg exhibit biological activities that may support its use in traditional medicine. This article provides an overview of the chemistry of secondary metabolites isolated from nutmeg kernel and mace including common methods for analysis of extracts and pure compounds as well as recent approaches towards total synthesis of some of the major constituents. A summary of the most significant pharmacological investigations of potential drug leads isolated from nutmeg and reported in the last decade is also included.

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Section: Pharmacological Evaluation Of Pure Nutmeg Compoundsmentioning

confidence: 99%

Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.)

Abourashed

El‐Alfy

2016

Phytochem Rev

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“…Myristicin has weak monoamine oxidase inhibitor properties that are responsible for some cardiovascular symptoms [9]. Myristicin displayed apoptotic activity mediated by the activation of caspases in hamster ovary CHO cells [10], and it also altered mitochondrial membrane function in human leukemia K562 cells, inducing apoptosis and down-regulating DNA damage response genes [11]. Myristicin has also been reported to cause psychotropic effects [12] and even death [5] at high dosages in humans, in which myristicin is metabolized to 3-methoxy-4,5-methylenedioxyampheta mine, the hallucinogenic effect of which was more pronounced than that of mescaline [12,13].…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2

Yang

Chen

et al. 2015

Chemico-Biological Interactions

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“…Recent studies have focused on the activity of non-nutritional dietary compounds that have protective or disease preventive properties (14)(15)(16). Myristicin (Myr; 1-allyl-5-methoxy-3,4-methylenedioxybenzene) is an active aromatic compound present in nutmeg (the seed of Myristica fragrans), carrot, basil, cinnamon and parsley (15). Myr has been revealed to have antibacterial (16), hepatoprotective (17), anti-inflammatory (18) and anticancer (15) effects.…”

Section: Introductionmentioning

confidence: 99%

“…Myristicin (Myr; 1-allyl-5-methoxy-3,4-methylenedioxybenzene) is an active aromatic compound present in nutmeg (the seed of Myristica fragrans), carrot, basil, cinnamon and parsley (15). Myr has been revealed to have antibacterial (16), hepatoprotective (17), anti-inflammatory (18) and anticancer (15) effects. Additionally, Myr has exhibited significant effects on the CNS.…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective effects of myristicin against hypoxia-induced apoptosis and endoplasmic reticulum stress in rat dorsal root ganglion neurons

Zhao

Liu

Shen

et al. 2017

Molecular Medicine Reports

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The aim of the present study was to investigate the role of myristicin (Myr; 1‑allyl‑5‑methoxy‑3,4‑methylenedioxybenzene), an active aromatic compound isolated from nutmeg, carrot, basil, cinnamon and parsley, in hypoxia‑induced apoptosis in rat dorsal root ganglion (DRG) neurons. It was observed that Myr significantly enhanced cell viability in hypoxia‑induced DRG neurons in a dose‑dependent manner; the optimal concentration of Myr was 50 µM. Furthermore, Myr reduced the percentage of deoxynucleotidyl transferase‑mediated dUTP nick end‑labeling‑positive neuronal cells and influenced the expression of the pro‑apoptotic gene B‑cell lymphoma 2 (Bcl‑2) associated X protein, the apoptosis protease cleaved caspase‑3 and the anti‑apoptotic gene Bcl‑2, in the hypoxia‑induced group. In addition, Myr protected against hypoxic injury in DRG neurons by inhibiting malondialdehyde and lactate dehydrogenase, however upregulating superoxide dismutase and glutathione peroxidase. Myr reduced the expression of endoplasmic reticulum stress (ERS) markers, including CCAAT/enhancer‑binding protein‑homologous protein, glucose‑related protein 78 and cleaved caspase‑12 in the hypoxia‑induced group. To the best of our knowledge, this is the first demonstration of the activity of Myr against hypoxia‑induced apoptosis in rat DRG neurons via inhibition of the ERS pathway.

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Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells

Cited by 39 publications

References 46 publications

Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.)

Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.)

Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2

Cytoprotective effects of myristicin against hypoxia-induced apoptosis and endoplasmic reticulum stress in rat dorsal root ganglion neurons

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