Myristic Acid, A Side Chain of Phorbol Myristate Acetate (PMA), Can Activate Human Polymorphonuclear Leukocytes to Produce Oxygen Radicals More Potently than PMA

Tada, Mika; Ichiishi, Eiichiro; Saito, Rumiko; Emoto, Natsumi; Niwano, Yoshimi; Kohno, Masahiro

doi:10.3164/jcbn.09-30

Cited by 11 publications

(8 citation statements)

References 28 publications

(28 reference statements)

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“…Also in a prospective study, men in the lower tercile of saturated fat consumption compared to those in the upper tercile had three times the risk of dying from PC [29]. The link between dietary fat content and the development of PC is possibly related to the increase in sex hormone and IGF-1 concentration [33], alteration of cell membrane function, and modulation of metabolic processes [34] or to increased oxygen radicals generation [35]. …”

Section: Discussionmentioning

confidence: 99%

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Lassed

Deus

Lourenço

et al. 2016

BioMed Research International

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Prostate cancer (PC) is the fourth most common cancer in men and the sixth leading cause of death in Algeria. To examine the relationship between lifestyle factors, including diet, and family history and PC risk, a case-control study was performed in an eastern Algerian population, comprising 90 patients with histologically confirmed PC and 190 controls. Data collection was carried out through a structured questionnaire and statistical analysis was performed to evaluate the different variables. The data showed that consumption of lamb and beef meat and high intake of animal fat and dairy products increased PC risk. Seven to thirteen vegetables servings per week and fourteen or more servings decreased PC risk by 62% and 96%, respectively. Seven to fourteen fruit servings per week decrease PC risk by 98%. Green tea consumption reduced the risk of PC but the results were statistically borderline. Increased risk was observed for individuals with family history of PC in first and in second degree. A positive strong association was also found for alcohol and smoking intake and a dose-response relationship existed for quantity and history of smoking. This study suggests that dietary habits, lifestyle factors, and family history have influence on the development of PC in Algerian population.

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Section: Discussionmentioning

confidence: 99%

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Lassed

Deus

Lourenço

et al. 2016

BioMed Research International

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“…Inositol is a growth factor that lowers the cholesterol level. Furthermore, the effects of metabolites that are negatively associated with the diversity are unknown (Arabinose) or with lower toxicity (Myristic Acid) 28 . We hence postulate that higher microbial diversity in the milk microbiome is likely a ‘signature’ of healthy milk microbiome of healthy mothers, and therefore beneficial to infants.…”

Section: Resultsmentioning

confidence: 99%

Integrated network-diversity analyses suggest suppressive effect of Hodgkin’s lymphoma and slightly relieving effect of chemotherapy on human milk microbiome

Sam

et al. 2016

Sci Rep

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We aim to investigate the effects of Hodgkin’s lymphoma and the chemotherapy for treating the disease on the human milk microbiome through integrated network and community diversity analyses. Our analyses suggest that Hodgkin’s lymphoma seems to have a suppressing effect on the milk microbiome by lowering the milk microbial community diversity, as measured by the Hill numbers profiles. Although the diversity analysis did not reveal an effect of chemotherapy on community diversity, bacterial species interaction network analysis shows that chemotherapy may help to slightly restore the milk microbiome impacted by Hodgkin’s lymphoma through its influence on the interactions among species (or OTUs). We further constructed diversity-metabolites network, which suggests that the milk microbial diversity is positively correlated with some beneficial milk metabolites such as DHA (DocosaHexaenoic Acid), and that the diversity is negatively correlated with some potentially harmful metabolites such as Butanal. We hence postulate that higher milk microbial diversity should be a signature of healthy mothers and beneficial to infants. Finally, we constructed metabolites OTU correlation networks, from which we identified some special OTUs. These OTUs deserve further investigations given their apparent involvements in regulating the levels of critical milk metabolites such as DHA, Inositol and Butanal.

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“…Myristic acid, is also known as tetradecanoic acid, which is a side chain of phorbol myristate acetate (PMA). It activates human polymorphonuclear leukocytes to produce oxygen radicals more potently than PMA does ( Tada et al, 2009 ). Although the levels of these two metabolites were downregulated in the raw SO group, we know that the organism is a balanced environment, and either too high or too low will have some effects.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Reveals the Mechanisms for the Pulmonary Toxicity of Siegesbeckia orientalis L. and the Toxicity-Reducing Effect of Processing

et al. 2021

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Siegesbeckia orientalis L. (SO) is a commonly used Chinese medicinal herb. It has long been used as a remedy in traditional Chinese medicine (TCM) for symptoms that resemble inflammatory joint disorders. However, it is slightly toxic. According to the TCM theory, processing can reduce the toxicity of the herbs. Here, we performed metabolomics to determine whether processing with rice wine reduces the toxicity of raw SO, and to explore the mechanisms underlying the raw SO–induced toxicity and the toxicity-reducing effect of processing. Our results showed that raw SO has long-term toxicity in rats. It significantly elevated the serum level of LDH and caused histopathological damages in the lung tissues. It is worth noting that the LDH level in the PSO group was lower than that in the raw SO group, and the damages in lung tissues were relatively mild in PSO-treated rats, suggesting that processing reduces the pulmonary toxicity of the raw. Moreover, a total of 32 significantly changed metabolites were identified. Based on the MetaboAnalyst pathway analysis, we found that two characteristic metabolic pathways including alanine, aspartate and glutamate metabolism and glycerophospholipid metabolism were only changed in the raw SO group, while histidine metabolism was only changed in the PSO group, which suggests that induction of oxidative stress contributes to raw SO–induced pulmonary toxicity, and free radical scavenging might be responsible for the toxicity-reducing effect of processing. Our data shed new light on how raw SO induces pulmonary toxicity and how the toxicity can be reduced by processing. This study not only provides scientific justifications for the traditional processing theory of SO, but also helps to optimize the processing protocol and the clinical drug combination of SO.

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Myristic Acid, A Side Chain of Phorbol Myristate Acetate (PMA), Can Activate Human Polymorphonuclear Leukocytes to Produce Oxygen Radicals More Potently than PMA

Cited by 11 publications

References 28 publications

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

Integrated network-diversity analyses suggest suppressive effect of Hodgkin’s lymphoma and slightly relieving effect of chemotherapy on human milk microbiome

Metabolomics Reveals the Mechanisms for the Pulmonary Toxicity of Siegesbeckia orientalis L. and the Toxicity-Reducing Effect of Processing

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