Myringosclerosis in patients with chronic renal failure: comparative analysis with a control group

Neto, Silvio Caldas; Lessa, Fábio de Souza; Alves, Gabriel; Caldas, Nelson; Gouveia, Mariana de Carvalho Leal

doi:10.1016/s1808-8694(15)30594-2

Cited by 3 publications

(9 citation statements)

References 30 publications

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“…Potentially higher in CKD on HD than in GP [13] The accumulation of serum phosphate binding to free calcium may lead to calcification in middle ear structures [13] Increased risk of myringosclerosis was found in CKD patients on HD lasting longer than 3 years [13] No similar association was found between HD duration and myringosclerosis formation [14] Vestibular dysfunction Vertigo…”

Section: Consensus Is Lackingmentioning

confidence: 99%

“…Calcification could also be formed in the lamina propria of the middle ear mucosa, however studies on this subject are sparse [13]. Matrix vesicles were presented as important elements of abnormal tissue calcification [14]. They also participated in other types of calcification, including tympanosclerosis [14].…”

Section: Tympanosclerosis Myringosclerosismentioning

confidence: 99%

“…Matrix vesicles were presented as important elements of abnormal tissue calcification [14]. They also participated in other types of calcification, including tympanosclerosis [14]. It was suggested that patients with CKD were more prone to develop myringosclerosis, a type of tympanosclerosis that affects tympanic membrane [14].…”

Section: Tympanosclerosis Myringosclerosismentioning

confidence: 99%

“…They also participated in other types of calcification, including tympanosclerosis [14]. It was suggested that patients with CKD were more prone to develop myringosclerosis, a type of tympanosclerosis that affects tympanic membrane [14]. Nevertheless, the correlation between the amount of serum phosphorus, calcium, magnesium or PTH, and myringosclerosis occurrence was not observed [13,14].…”

Section: Tympanosclerosis Myringosclerosismentioning

confidence: 99%

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Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages

Wojciechowska

Krajewski

Zatoński

2020

Eur Arch Otorhinolaryngol

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Purpose Otorhinolaryngological abnormalities are common complications of chronic kidney disease (CKD) and its treatment. The main aim of this study was to provide a brief and precise review of the current knowledge regarding CKD and its treatment-related influence on head and neck organs. Methods The Medline and Web of Science databases were searched using the terms "chronic kidney disease", "kidney transplantation", "immunosuppression", "dialysis" in conjunction with "otorhinolaryngological manifestation". Articles that did not address the topics, low-quality studies, case reports, and studies based on nonsignificant cohorts were excluded, and the full text of remaining high-quality, novel articles were examined and elaborated on. Results Patients with CKD are prone to develop sensorineural hearing loss, tinnitus, recurrent epistaxis, opportunistic infections including oropharyngeal candidiasis or rhino-cerebral mucormycosis, taste and smell changes, phonatory and vestibular dysfunctions, deep neck infections, mucosal abnormalities, gingival hyperplasia, halitosis or xerostomia. Immunosuppressive therapy after kidney transplantation increases the risk of carcinogenesis, both related and not-related to latent viral infection. The most commonly viral-related neoplasms observed in these patients are oral and oropharyngeal cancers, whereas the majority of not-related to viral infection tumors constitute lip and thyroid cancers. CKD-related otorhinolaryngological dysfunctions are often permanent, difficult to control, have a significant negative influence on patient's quality of life, and can be life threatening. Conclusion Patients with CKD suffer from a number of otorhinolaryngological CKD-induced complications. The relationship between several otorhinolaryngological complications and CKD was widely explained, whereas the correlation between the rest of them and CKD remains unclear. Further studies on this subject are necessary.

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Section: Consensus Is Lackingmentioning

confidence: 99%

Section: Tympanosclerosis Myringosclerosismentioning

confidence: 99%

Section: Tympanosclerosis Myringosclerosismentioning

confidence: 99%

Section: Tympanosclerosis Myringosclerosismentioning

confidence: 99%

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Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages

Wojciechowska

Krajewski

Zatoński

2020

Eur Arch Otorhinolaryngol

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“…Caldas et al [13] investigated the prevalence of MS in 341 patients with chronic renal failure (CRF), which induces pathological calcifications in various tissues, similar to MS, and 356 normal healthy controls as a control group using otoscopic examinations. They observed myringosclerotic foci in 40 (11.7%) of 341 CRF patients and in 18 (5.1%) of 356 control subjects.…”

Section: Involvement Of Ts Is Termed Msmentioning

confidence: 99%

A Post-Tympanoplasty Evaluation of the Factors Affecting Development of Myringosclerosis in the Graft: A Clinical Study

Özbay¹,

Dündar²,

Kulduk³

et al. 2014

Int Adv Otol

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OBJECTIVE: Myringosclerosis (MS) is a pathological condition characterized by hyaline degeneration and calcification of the collagenous structure of the fibrotic layer of the tympanic membrane, which may develop after trauma, infection, or inflammation as myringotomy, insertion of a ventilation tube, or myringoplasty. The aim of our study was to both reveal and evaluate the impact of the factors that might be effective on the post-tympanoplasty development of myringosclerosis in the graft. MATERIALS and METHODS:In line with this objective, a total of 108 patients (44 males and 64 females) aged between 11 and 66 years (mean age, 29.5 years) who had undergone type 1 tympanoplasty (TP) with an intact canal wall technique and type 2 TP, followed up for an average of 38.8 months, were evaluated. In the presence of myringosclerosis, in consideration of the tympanic membrane (TM) quadrants involved, the influential factors were analyzed in our study, together with the development of myringosclerosis, including preoperative factors, such as the presence of myringosclerosis in the residual and also contralateral tympanic membrane, extent and location of the perforation, and perioperative factors, such as tympanosclerosis in the middle ear and mastoid cavity, cholesteatoma, granulation tissue, and type of the operation performed. For statistical analysis of data, independent samples t-test was used. RESULTS:Our study comprised 44 male and 64 female patients. Median postoperative follow-up period was estimated as 38.8 months. The rate of postoperative development of myringosclerosis in grafts was significantly higher in patients with already existing sclerotic foci in TM (p=0.001). The location of the perforation had no effect on the postoperative development of MS in the graft (p=0.521). No statistically significant difference was detected between the size of the perforation and formation of MS (p=0.581). Statistical analysis of both groups could not discern any significant intergroup difference as to the impact of the presence or absence of cholesteatoma on the development and extent of MS (p=0.604). Impact of tympanosclerosis on the postoperative development and extent of MS in the graft was significant (p=0.001). Presence or absence of granulation tissue on the development or extent of myringosclerosis was not detected (p=0.697). Myringosclerotic foci in the contralateral ears had a statistically significant effect on the postoperative development and extent of MS in the grafts (p=0.001). Type of surgery performed did not exert any significant effect on the development or extent of myringosclerosis (p=0.765). CONCLUSION:We have determined that the presence of myringosclerosis in the residual membrane and in the contralateral tympanic membrane and tympanosclerosis in the middle ear have a significant role in the development of postoperative myringosclerosis in the tympanic membrane, contrary to the type of the surgical intervention, location and extent of perforation, presence of cholesteatoma, and granulation tissue.

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Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels

Doğan¹

2016

KBB Uygulamaları

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Bu çalışmada yaygın timpanosklerozis ile serum kalsiyum, fosfor, D vitamini ve paratiroid hormonu düzeyleri arasındaki ilişki araştırıldı. Hastalar ve Yöntemler: Bu çalışma, Ekim 2014-Mayıs 2015 tarihleri arasında, Kayseri Eğitim Araştırma Hastanesi Kulak Burun Boğaz ve Baş Boyun Cerrahisi Bölümü'nde yürütüldü. Yaygın timpanosklerozis tanısı konulan 37 hasta (18 erkek, 19 kadın; ort. yaş 35.4 yıl; dağılım 18-77 yıl) ile çalışma grubu oluşturuldu. Otuz iki sağlıklı birey (15 erkek, 17 kadın; ort. yaş 32.2 yıl; dağılım 18-67 yıl) kontrol grubu olarak alındı. Çalışmaya katılan her bireyin serum total kalsiyum, fosfor, D vitamini, paratiroid hormonu ve albümin düzeyleri analiz edildi. Serum albümin ile düzeltilmiş kalsiyum değerlerini elde etmek için, total kalsiyum seviyeleri serum albümin seviyelerine göre düzeltildi. Bulgular: Ortalama serum fosfor, D vitamini ve paratiroid hormonu değerleri çalışma grubunda anlamlı oranda yüksek iken, serum total kalsiyum ve albümin ile düzeltilmiş kalsiyum değerleri bakımından iki grup arasında anlamlı fark yoktu. Sonuç: Her ne kadar bu çalışma grubunda serum fosfor, D vitamini ve paratiroid hormonu düzeyleri ile yaygın timpanosklerozis arasında ilişki bulunsa da bu serum parametrelerinin, timpanosklerozis gelişiminin hücresel mekanizmalarındaki potansiyel rolü üzerine ileri çalışmalara ihtiyaç vardır.

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Myringosclerosis in patients with chronic renal failure: comparative analysis with a control group

Cited by 3 publications

References 30 publications

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages

Otorhinolaryngological dysfunctions induced by chronic kidney disease in pre- and post-transplant stages

A Post-Tympanoplasty Evaluation of the Factors Affecting Development of Myringosclerosis in the Graft: A Clinical Study

Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels

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