Myricetin inhibits migration and invasion of hepatocellular carcinoma MHCC97H cell line by inhibiting the EMT process

Ma, Hao; Zhu, Lei; Ren, Jing-Na; Benlong, Rao; Sha, Maomao; Kuang, Yi; Shen, Weishou; Xu, Zhengxin

doi:10.3892/ol.2019.10998

Cited by 15 publications

(16 citation statements)

References 24 publications

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“…Chemotherapy during the early stage of NSCLC is still needed in the targeted therapy era 19 . As a natural compound, myricetin exerts antiproliferative and anti‐metastatic effects on several tumor cells 20,21 . Here, we focused on the biological functions of four synthesized myricetin derivatives in the regulation of NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Anticancer effects of myricetin derivatives in non‐small cell lung cancer in vitro and in vivo

Zha

Chen

et al. 2021

Pharmacology Res & Perspec

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Lung cancer is the most common cause of cancer‐related deaths. Moreover, exploring efficient tumor‐killing drugs is urgently needed. In our study, several derivative compounds of myricetin were synthesized and tested. Experiments on non‐small cell lung cancer (NSCLC) showed that S4‐2‐2 (5,7‐dimethoxy‐3‐(4‐(methyl(1‐(naphthalen‐2‐ylsulfonyl)piperidin‐4‐yl)amino)butoxy)‐2‐(3,4,5‐trimethoxyphenyl)‐4H‐chromen‐4‐one) had the strongest effect on A549 cell inhibition across all compounds. Furthermore, S4‐2‐2‐treated A549 cells were also suppressed when transplanted into immunodeficient mice. Particularly, we found that the migration and invasiveness of A549 cells became suppressed upon treatment with S4‐2‐2. Furthermore, the compound significantly induced cell apoptosis, but did not affect the cell cycle of A549 cells. Finally, we revealed that S4‐2‐2 inhibited the biological function of NSCLC cells by regulating the protein process in the endoplasmic reticulum, and then by inducing the expression of apoptosis‐related proteins. Taken together, S4‐2‐2 was shown to act as a potential molecular inhibitor of A549 cells.

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Section: Discussionmentioning

confidence: 99%

Anticancer effects of myricetin derivatives in non‐small cell lung cancer in vitro and in vivo

Zha

Chen

et al. 2021

Pharmacology Res & Perspec

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“…Myricetin has also been reported to inhibit the migration and invasion of hepatocellular carcinoma MHCC97H cells and weaken filopodia and lamellipodia [142]. Myricetin also up-regulates E-cadherin expression while downregulating N-cadherin [142]. Collectively, these findings suggest that myricetin suppresses the process of epithelial-mesenchymal transition (EMT), thereby impeding the migration and invasion of hepatocellular carcinoma cells [142].…”

Section: Myricetinmentioning

confidence: 88%

“…In particular, the BRCA1-GADD45 pathway was involved in the apoptotic death of the T47D cells [141]. Myricetin has also been reported to inhibit the migration and invasion of hepatocellular carcinoma MHCC97H cells and weaken filopodia and lamellipodia [142]. Myricetin also up-regulates E-cadherin expression while downregulating N-cadherin [142].…”

Section: Myricetinmentioning

confidence: 98%

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

2022

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Cancer is one the most malignant diseases that is a leading cause of death worldwide. Vegetables and fruits contain beneficial nutrients such as vitamins, minerals, folates, dietary fibers, and various natural bioactive compounds. These can prevent the pathological processes of many cancers and reduce cancer related mortality. Specifically, the anti-cancer effect of vegetables and fruits is largely attributable to the natural bioactive compounds present within them. A lot of bioactive compounds have very specific colors with pigments and the action of them in the human body varies by their color. Red-pigmented foods, such as apples, oranges, tomatoes, cherries, grapes, berries, and red wine, have been widely reported to elicit beneficial effects and have been investigated for their anti-tumor, anti-inflammatory, and antioxidative properties, as well as anti-cancer effect. Most of the anti-cancer effects of bioactive compounds in red-pigmented foods arise from the suppression of cancer cell invasion and metastasis, as well as the induction of apoptosis and cell cycle arrest. In this review, we assessed publications from the last 10 years and identified 10 bioactive compounds commonly studied in red-pigmented foods: lycopene, anthocyanin, β-carotene, pectin, betaine, rutin, ursolic acid, kaempferol, quercetin, and myricetin. We focused on the mechanisms and targets underlying the anti-cancer effect of the compounds and provided rationale for further investigation of the compounds to develop more potent anti-cancer treatment methods.

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“…16 Other polyphenols present in the maqui fruit have also been implicated in the reduction of cell invasion through a reduction of matrix metalloproteinases. Myricetin inhibits invasion in hepatocellular carcinoma cells 50 and kaempferol reduces invasion in breast cancer cells and reduces lung metastasis of B16 mice melanoma cells. 51…”

Section: Discussionmentioning

confidence: 99%

Hydroethanolic Extracts of the Aristotelia Chilensis (Maqui) Berry Reduces Cellular Viability and Invasiveness in the Endometrial Cancer Cell Line Ishikawa

et al. 2021

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Cancer of the reproductive tract includes diseases with higher prevalence in the female population. This investigation examined whether an anthocyanin-enriched extract of Aristotelia chilensis, commonly known as “maqui,” could affect some hallmarks of endometrial cancer. Cultures of the human endometrial cancer cell line Ishikawa were treated with a hydroethanolic maqui extract at 1, 3, 10, 30, 100, 300, or 1000 µg/mL to determine the effect on cell viability by MTT assay. Then, we used the 50% Effective Concentration (EC50) to evaluate whether the effect of the maqui extract is mediated via an arrest of the cell cycle or induction of apoptosis using flow cytometry or Annexin V-FITC assays, respectively. The effects of sublethal doses of the maqui extract on migration and invasiveness of Ishikawa cells were also evaluated by the wound healing and Boyden Chamber assay, respectively. Our results show that the hydroethanolic maqui extract inhibits the cell viability with an EC50 of 472.3 µg/mL via increased apoptosis, and that reduces the invasive capacity but not migration of Ishikawa cells. These findings suggest that the hydroethanolic maqui extract has antineoplastic properties for endometrial cancer and merits further studies to corroborate its efficiency as anticancer therapy in reproductive organs.

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Myricetin inhibits migration and invasion of hepatocellular carcinoma MHCC97H cell line by inhibiting the EMT process

Cited by 15 publications

References 24 publications

Anticancer effects of myricetin derivatives in non‐small cell lung cancer in vitro and in vivo

Anticancer effects of myricetin derivatives in non‐small cell lung cancer in vitro and in vivo

The Anti-Cancer Effects of Red-Pigmented Foods: Biomarker Modulation and Mechanisms Underlying Cancer Progression

Hydroethanolic Extracts of the Aristotelia Chilensis (Maqui) Berry Reduces Cellular Viability and Invasiveness in the Endometrial Cancer Cell Line Ishikawa

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