Myricetin improves metabolic outcomes but not cognitive deficit associated to metabolic syndrome in male mice

Coêlho, Caio Fernando Ferreira; Souza, Ivana Letícia Santos; Chagas, Vinicyus Teles; Ribeiro, Nathalee Liberal Xavier; Pinto, Bruno; França, Lucas Martins

doi:10.1039/d1fo00073j

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…Profiling of phytochemicals in tissues from S. birrea using HPLC-MS revealed the presence of phenolic compounds such as epigallocatechin-3-gallate (EGCG) and myricetin [ 18 ]. While EGCG has previously been shown to attenuate body and liver weights and hepatic steatosis, myricetin has been reported to reduce serum triglycerides, insulin insensitivity and hepatic steatosis [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice

Mabasa

Kotze

Shabalala

et al. 2022

IJERPH

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Non-alcoholic fatty liver disease (NAFLD) is a spectrum of hepatic metabolic perturbations ranging from simple steatosis to steatohepatitis, cirrhosis and hepatocellular carcinoma. Currently, lifestyle modifications to reduce weight gain are considered the most effective means of preventing and treating the disease. The aim of the present study was to determine the therapeutic benefit of Sclerocarya birrea (Marula leaf extract, MLE) on hepatic steatosis. Obese db/db mice were randomly stratified into the obese control, metformin (MET) or MLE-treated groups. Mice were treated daily for 29 days, at which point all mice were euthanized and liver samples were collected. Hematoxylin and eosin staining was used for histological assessment of the liver sections, while qRT-PCR and Western blot were used to determine hepatic mRNA and protein expression, respectively. Thereafter, the association between methylenetetrahydrofolate reductase (Mthfr a key enzyme in one-carbon metabolism and DNA-methylation-induced regulation of gene transcription) and lipogenic genes was evaluated using Pearson’s correlation coefficient. Mice treated with MLE presented with significantly lower body and liver weights as compared with the obese control and MET-treated mice (p ≤ 0.05). Further, MLE treatment significantly inhibited hepatic steatosis as compared with the obese control and MET-treated mice (p ≤ 0.05). The reduced lipid accumulation was associated with low expression of fatty acid synthase (Cpt1; p ≤ 0.05) and an upregulation of the fatty acid oxidation gene, carnitine palmitoyltransferase (Cpt1; p ≤ 0.01), as compared with the obese control mice. Interestingly, MLE treatment improved the correlation between Mthfr and Cpt1 mRNA expression (r = 0.72, p ≤ 0.01). Taken together, the results suggest that Marula leaf extracts may inhibit hepatic steatosis by influencing the association between Mthfr and genes involved in hepatic lipid metabolism. Further studies are warranted to assess DNA methylation changes in lipid metabolism genes.

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Section: Discussionmentioning

confidence: 99%

Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice

Mabasa

Kotze

Shabalala

et al. 2022

IJERPH

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“…At treatments with EE of S. melongena of fructose-fed rats, glomeruli were observed with endothelial cells, podocytes, and mesangial cells with hyperchromatic nuclei, hypercellularity was maintained, and no atrophic corpuscles were observed. Possibly, this effect is due to the presence of oleanolic (22,23) and ursolic acid (24) quercetin ( 25) myricetin (26) and galangin (27) which have shown nephroprotective effects.…”

Section: Kidney Damagementioning

confidence: 99%

Effect of Solanum melongena on Components and Kidney Damage of Fructose-Induced Metabolic Syndrome in Rats

Hernández,

González Valle,

Benítez Flores

et al. 2024

Iran J Pharm Res

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: In traditional Mexican medicine, Solanum melongena is used to treat obesity, diabetes mellitus, hypertension, asthma, bronchitis, arthritis, and hypercholesterolemia. This study examined the effect of treatment with ethanolic extract (EE) from the fruit of S. melongena on kidney damage on metabolic syndrome (MS). Male Wistar rats were maintained for 12 weeks on a diet of 20% fructose in drinking water and chow to develop MS. After administering EE of S. melongena (100 and 200 mg/kg/day, orally) for 6 weeks, the histological study of the kidney cortex and determination by Western blot of the renal expression of angiotensin II AT1 receptor and cytokine transforming growth factor beta 1 (TGF-β1) were realized. The rats fed with high fructose developed MS and showed kidney damage characterized by proliferative glomerulonephritis and necrosis; this damage was reduced by S. melongena treatment and associated with decreased expression of AT1 receptor for angiotensin II and cytokine TGF-β1, controlling renal damage in this animal model. In rats affected by MS through high fructose feeding, the treatment with EE of S. melongena showed a renoprotective effect through decreased expression of AT1 receptor for angiotensin II and cytokine TGF-β1, causes of glomerulonephritis.

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Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice

Zhu,

Dai,

Zhao

et al. 2024

Gut Microbes

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Myricetin improves metabolic outcomes but not cognitive deficit associated to metabolic syndrome in male mice

Abstract: Myricetin is a flavonol highly prevalent in edible vegetables and fruits, with recognized hypoglycemic and anti-obesity effects, besides great antioxidant capacity. Thus, this study sought to investigate whether myricetin is...

Cited by 4 publications

References 51 publications

Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice

Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice

Effect of Solanum melongena on Components and Kidney Damage of Fructose-Induced Metabolic Syndrome in Rats

Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice

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