Myricetin alleviates H2O2-induced senescence and apoptosis in rat nucleus pulposus-derived mesenchymal stem cells

Xie, Tianqi; Pan, Ruijie; Huang, Wenwen; Dong, Sheng; Wu, Szu-Yuan; Ye, Y.

doi:10.5603/fhc.a2023.0007

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…And it has been demonstrated that populin can prevent intervertebral disc degeneration in rats through the Nrf2/HO-1/NF-κB signaling pathway (Mao and Fan 2023). Xie et al (2023) found that populin affected the SIRT1/PGC-1α pathway to protect mitochondrial function and alleviate cellular senescence in H 2 O 2 -treated myeloid MSCs. Overall, SIRT1 can directly or indirectly activate Nrf2 and regulate the expression of antioxidant genes to protect the cells from oxidative stress damage.…”

Section: Role Of Sirtuins In Enhancing Antioxidant Defensesmentioning

confidence: 99%

Sirtuins in intervertebral disc degeneration: current understanding

Shen,

Lan,

et al. 2024

Mol Med

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Background Intervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to a variety of pathological spinal conditions such as disc herniation, spinal stenosis, and scoliosis. IVDD is a leading cause of lower back pain, the prevalence of which increases with age. Recently, Sirtuins/SIRTs and their related activators have received attention for their activity in the treatment of IVDD. In this paper, a comprehensive systematic review of the literature on the role of SIRTs and their activators on IVDD in recent years is presented. The molecular pathways involved in the regulation of IVDD by SIRTs are summarized, and the effects of SIRTs on senescence, inflammatory responses, oxidative stress, and mitochondrial dysfunction in myeloid cells are discussed with a view to suggesting possible solutions for the current treatment of IVDD. Purpose This paper focuses on the molecular mechanisms by which SIRTs and their activators act on IVDD. Methods A literature search was conducted in Pubmed and Web of Science databases over a 13-year period from 2011 to 2024 for the terms “SIRT”, “Sirtuin”, “IVDD”, “IDD”, “IVD”, “NP”, “Intervertebral disc degeneration”, “Intervertebral disc” and “Nucleus pulposus”. Results According to the results, SIRTs and a large number of activators showed positive effects against IVDD.SIRTs modulate autophagy, myeloid apoptosis, oxidative stress and extracellular matrix degradation. In addition, they attenuate inflammatory factor-induced disc damage and maintain homeostasis during disc degeneration. Several clinical studies have reported the protective effects of some SIRTs activators (e.g., resveratrol, melatonin, honokiol, and 1,4-dihydropyridine) against IVDD. Conclusion The fact that SIRTs and their activators play a hundred different roles in IVDD helps to better understand their potential to develop further treatments for IVDD. Novelty This review summarizes current information on the mechanisms of action of SIRTs in IVDD and the challenges and limitations of translating their basic research into therapy.

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Section: Role Of Sirtuins In Enhancing Antioxidant Defensesmentioning

confidence: 99%

Sirtuins in intervertebral disc degeneration: current understanding

Shen,

Lan,

et al. 2024

Mol Med

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“…Silencing of SERPINE1 (selected after RNA-seq, bioinformatics and gene ontology enrichment analysis) inhibited H 2 O 2 -induced cellular senescence, while SERPINE1 overexpression using an overexpression plasmid reversed the myricetin-induced anti-senescence and anti-inflammatory effects [ 61 ]. Furthermore, myricetin has been shown to exhibit a protective effect against H 2 O 2 -induced mitochondrial dysfunction (i.e., it moderated increased mitochondrial ROS and damaged mitochondrial membrane potential) and to prevent H 2 O 2 -induced cellular senescence (by decreasing p16 INK4a , p21 WAF1 and p53 expression and SA-β-Gal activity) in rat NP mesenchymal stem cells in vitro via the SIRT1/PGC-1α pathway [ 62 ].…”

Section: Plant-derived Compounds With a Reported Senotherapeutic Acti...mentioning

confidence: 99%

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Mavrogonatou,

Kletsas

2024

Metabolites

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Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged and degenerated intervertebral discs and their senescence-associated secretory phenotype (SASP) has been connected with qualitative/quantitative alterations in the extracellular matrix and ultimately with the disturbance of tissue homeostasis. Given that selective elimination of senescent cells (by the so-called senolytics) or amendment of their secretome towards a less catabolic/inflammatory phenotype (by molecules known as senomorphics) has been reported to alleviate symptoms of several age-associated diseases and to improve tissue quality during aging, here we will review the emerging role of senolytic and senomorphic agents derived from plants and natural products against intervertebral disc degeneration. The mode of action of these senotherapeutics, as well as the challenges in their practical application, will also be explicitly discussed in an attempt to direct their more targeted and effective use in exclusive or combinatorial therapeutic schemes for the prevention and/or treatment of disc degenerative disorders.

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“… 10 Among these compounds, myricetin (MC), a major component of the total flavones in Pterocarya rhoifolia, 11 stands notable for its remarkable therapeutic effects. 12 It possesses various pharmacological properties, including anti-aging of stem cells, 13 anti-hyperlipidemia, 14 anti-diabetic, 15 and anti-inflammatory effects. 16 Myricetin has been shown to significantly reduce inflammation in RA through different mechanisms, including modulation of IL-21 and histone K activity and targeting AIM2 to inhibit fibroblast-like synoviocyte-mediated rheumatoid synovial inflammation and joint destruction.…”

Section: Introductionmentioning

confidence: 99%

Myricetin reduces neutrophil extracellular trap release in a rat model of rheumatoid arthritis, which is associated with a decrease in disease severity

Shu,

Yang,

Wen

et al. 2024

Innate Immun

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Rheumatoid arthritis (RA) is a chronic disease characterized by joint inflammation and severe disability. However, there is a lack of safe and effective drugs for treating RA. In our previous study, we discovered that myricetin (MC) and celecoxib have a synergistic effect in the treatment of RA. We conducted in vitro and in vivo experiments to further investigate the effects and mechanisms of action of MC. Our findings demonstrated that MC treatment effectively reduced the release of neutrophil extracellular traps (NETs) and alleviated the inflammatory response in RA. Mechanistic studies showed that MC prevents the entry of PADI4 and MPO into the cell nucleus, thereby protecting DNA from decondensation. In a rat arthritis model, MC improved histological changes in ankle joints and suppressed NET-related signaling factors. In conclusion, MC protects the ankle joints against arthritis by inhibiting MPO and PADI4, thereby reducing NET release. The pharmacological mechanism of MC in RA involves the inhibition of NET release.

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Myricetin alleviates H2O2-induced senescence and apoptosis in rat nucleus pulposus-derived mesenchymal stem cells

Cited by 6 publications

References 51 publications

Sirtuins in intervertebral disc degeneration: current understanding

Sirtuins in intervertebral disc degeneration: current understanding

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Myricetin reduces neutrophil extracellular trap release in a rat model of rheumatoid arthritis, which is associated with a decrease in disease severity

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