“…Some mappers incorporate the idea of using less computationalintensive alternatives to SW and use pre-alignment filters to discard alignment candidates, hence, moving from the SE approach to the Seed-Filter-and-Extend (SFE) approach. Among other algorithms, the filtering phase might use Bit-Parallel Myers (BPM) [3], which has been optimized for CPUs [4], [5], GPUs [6], and FPGAs [7], [8]. However, the SFE approach introduce some constraints that allow optimizations to be applied that are not considered when using the BPM technique.…”