MyPeBS International randomized study comparing personalised, risk-stratified to standard breast cancer screening in women aged 40–70: Focus on recruitment strategy in France

A scoping review of programme specific mammographic breast density related guidelines and practices within breast screening programmes

“…Personalised breast screening aims to overcome the limitations of the current age-based approach adopted by BSPs and determine an appropriate tailored screening approach based on a woman’s individual risk [83] , [84] . Current ongoing clinical trials include the international randomised controlled study, My Personal Breast Screening (MyPeBS), which is assessing the effectiveness of an individual risk based approach compared to the standard approach in the different study sites [85] , [86] . MBD is considered in both arms of the study and is also incorporated into the risk calculations conducted as part of the intervention [85] , [86] .…”

“…Current ongoing clinical trials include the international randomised controlled study, My Personal Breast Screening (MyPeBS), which is assessing the effectiveness of an individual risk based approach compared to the standard approach in the different study sites [85] , [86] . MBD is considered in both arms of the study and is also incorporated into the risk calculations conducted as part of the intervention [85] , [86] . In the USA, the Women Informed to Screen Depending On Measures of risk (WISDOM) study is comparing annual screening to a personalised screening approach incorporating MBD, lifestyle risk factors, and genetic risk factors in the risk assessments [87] .…”

Clinical Impact of Polygenic Risk Score for Breast Cancer Risk Prediction in 382 Individuals with Hereditary Breast and Ovarian Cancer Syndrome

“…Belgium, France, Israel, Italy, the United Kingdom, and Spain are comparing personalized, risk-stratified BC screening to standard screening as part of the ongoing international MyPeBS study [19]. In Germany, however, the use of the PRS for risk prediction has not yet been incorporated into the daily practice of genetic counselling for familial BC.…”

Personalized Approaches for the Prevention and Treatment of Breast Cancer

“…This international, multidisciplinary project comprises four interconnected activities covering all major dimensions of research (i.e., basic, clinical, and population). In addition to the WISDOM study in the United States (US) [ 23 ] and MyPeBS in Europe and Israel [ 24 ], the PERSPECTIVE I&I project constitutes one of the major international initiatives studying better ways to use risk-based stratification to prevent consequential cancers [ 15 ]. By assessing health system organizational readiness, and considering social, ethical, legal, and economic issues related to BC risk prediction and communication, this project is expected to generate much-needed evidence to support the implementation of a more personalized BC-screening approach.…”