Myotonic muscular dystrophy associated with ritodrine tocolysis

Nemaline myopathy in the neonate: two case reports

“…As in our two patients, the literature [2,7,9] reports that hydramnion and decreased fetal movements were the most frequent symptoms during pregnancy. Fetal activity as perceived by the mothers proved to correlate highly with objective measurements of fetal movement [3].…”

“…These pregnancies are often complicated by preterm labour (as in case 1), and perhaps dysfunctional uterine contractions [7,9]. During the delivery, dystocia is frequent because of hydramnion and abnormal fetal muscle tone [7].…”

Exploring Risk Factors that Contribute to the Onset of Ritodrine-Associated Serious Adverse Drug Reactions

“…Drastic changes in potassium concentration inside the cell cause instability in muscle-cell membrane and increase the probability of muscle cell damage [21].…”

“…Mg increases uterotonic activity associated with ritodrine [9], promotes changes in Ca 2+ concentration in the cells and destabilizes the cell membrane because of electrolyte abnormality; thus, it is possible that Mg could cause muscle cell damage [21]. A concomitant treatment with Mg enhances ritodrine's effect on muscle cells; thus, rhabdomyolysis might be likely to occur.…”

Drug induced myopathies

“…The β2-adrenergic blockers propranolol and pindolol and the β2-agonists fenoterol and ritrodrine, can also aggravate myotonia 40. A number of diuretics, including frusemide, ethacrynic acid, mersalyl, and acetazolamide can induce myotonia experimentally and should be used with caution in individuals with hereditary forms of myotonia 41.…”