Myostatin (MSTN) gene duplications in Atlantic salmon (Salmo salar): Evidence for different selective pressure on teleost MSTN-1 and -2

Østbye, Tone-Kari K; Wetten, Ola Frang; Tooming‐Klunderud, Ave; Jakobsen, Kjetill S.; Yafe, Anat; Etzioni, Shulamit; Moen, Thomas; Andersen, Øivind

doi:10.1016/j.gene.2007.08.008

Cited by 70 publications

(42 citation statements)

References 65 publications

(72 reference statements)

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“…A selection pressure on MSTN has been postulated also in bovid where, instead, the observed accelerated evolution of the gene sequence has been explained as the consequence of remote naturally occurring selection (Tellgren et al, 2004). Finally, putative naturally occurring selection has been evoked in salmonids (Ostbye et al, 2007). Based on the above, we decided to partially sequence the MSTN gene in an economical relevant livestock species, Camelus dromedarius, for which only a 256 bp region in the first exon of the MSTN locus was available up to now.…”

Section: Introductionmentioning

confidence: 99%

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Muzzachi

Oulmouden

Cherifi

et al. 2015

Emir. J. Food Agric

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Myostatin (MSTN), a negative regulator of skeletal muscle development in mammals, represents a key target for genetic investigations in meat-producing animals, with mutations responsible for increased skeletal-muscle mass currently described in several livestock species. Dromedary camels play a major economic role as suppliers of meat for human consumption across several countries. Notwithstanding, a comprehensive characterization of the sequence variability at the Camelus dromedarius MSTN locus was still lacking. Here we present the first extensive sequence and polymorphism analysis of the MSTN gene in the C. dromedarius species. Out of more than 3.6 kb of nucleotide sequence screened on 22 animals from 3 different Northern African regions, only 3 variant sites in the first intron were detected. The low observed diversity may reflect the evolutionary history of the species, likely developed as domesticates from a low variable wild ancestor population. Sequence identity among C. dromedarius and other Cetartiodactyla highlighted a tree topology consistent with previous reports of a closer relationship between Tylopoda and Suiformes. A close similarity between C. ferus and C. dromedarius was observed within Tylopoda. A markedly higher sequence identity between C. dromedarius and the other vertebrate species was observed at the MSTN locus compared to other genes, thus confirming it as a highly conserved target across mammals.

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Section: Introductionmentioning

confidence: 99%

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Muzzachi

Oulmouden

Cherifi

et al. 2015

Emir. J. Food Agric

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“…Homozygous mutant animals were about 30% larger and showed total muscle cell 86% higher than their heterozygous and wild types littermates. 12 Natural mutations of MSTN gene correlated to increased muscle mass were also identified in cattle, 38 sheep, 39 dogs, 40 fishes, 41 humans, 42 horses. 43 The very high muscle mass to body weight ratio observed in horses (55%), compared to other species, 3 is probably a trait targeted for artificial selection, especially in Thoroughbred horses.…”

Section: Genes Of Interest Mstn Genementioning

confidence: 94%

Brief Review of Equine Genomics: Prospects toward Exercise and Sports Science

Bogossian¹

2017

MOJSM

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Since horse's domestication, physical and physiological capacities have been targeted for selection, leading to the notable functional adaptations to exercise and training of the actual phenotypes registered in equestrian disciplines. During the past ten years, experiments using next generation sequencing attempted to identify specific loci in the equine genome associated with traits of interest (e.g. speed, stamina, strength). Some of these investigations are reviewed in this study within a comprehensive and comparative approach.

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“…On the other hand, myostatin appears to be more ubiquitously expressed in fish, suggesting that its contributions to the growth and development of fish are more diverse (Radaelli et al, 2003;Helterline et al, 2007). Consistent with this idea, teleost fishes possess at least two myostatin genes, which are differentially expressed in both muscle and non-muscle tissues, whereas myostatin is encoded by a single gene in mammals (Biga et al, 2005;Kerr et al, 2005;Østbye et al, 2007). Myostatin cDNA has been characterized in a number of commercially important fishes, including rainbow trout (Rescan et al, 2001), Atlantic salmon (Østbye et al, 2001), Mozambique tilapia , white bass and striped bass , gilthead sea bream (Maccatrozzo et al, 2001a), catfish (Gregory et al, 2004) and grouper (Ko et al, 2007), among others; and expression of myostatin mRNA has been detected in a variety of tissues and at different stages of development in some fish species (Rescan et al, 2001;Østbye et al, 2001;Maccatrozzo et al, 2001a,b;Kocabas et al, 2002;Roberts and Goetz, 2003;Vianello et al, 2003;Xu et al, 2003;Gregory et al, 2004;Ko et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Methylation status and chromatin structure of the myostatin gene promoter region in the sea perch Lateolabrax japonicus (Perciformes)

Abbas

Takayanagi²,

Shimizu³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Myostatin is a negative regulator of the growth and development of skeletal muscle mass. In fish, myostatin is expressed in several organs in addition to skeletal muscle. To understand the mechanisms regulating myostatin gene expression in the sea perch, Lateolabrax japonicus, we examined the methylation status of the myostatin gene promoter region in several tissues (liver, eye, kidney, brain, and heart) isolated from adult specimens. The frequency of methylated cytosines was very low in all tissues, regardless of the level of myostatin expression, suggesting that DNA methylation is not involved in the tissue-specific regulation of myostatin expression. Southern blot analysis of genomic DNA obtained from micrococcal nucleasetreated nuclei showed that chromatin digestion occurs in tissues where the myostatin gene is actively transcribed and that the myostatin gene is protected from micrococcal nuclease in tissues where myostatin is not expressed. The chromatin structure in the myostatin gene region

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Myostatin (MSTN) gene duplications in Atlantic salmon (Salmo salar): Evidence for different selective pressure on teleost MSTN-1 and -2

Cited by 70 publications

References 65 publications

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Brief Review of Equine Genomics: Prospects toward Exercise and Sports Science

Methylation status and chromatin structure of the myostatin gene promoter region in the sea perch Lateolabrax japonicus (Perciformes)

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