Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis

Lee, Su Jin; Gharbi, Amal; Shin, Joo Eun; Jung, In Duk; Park, Yeong Min

doi:10.1016/j.bbrc.2021.01.030

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…The skin samples of the dorsal lesions were collected from all groups, fixed in 10% formalin solution, and embedded in paraffin. The tissues were processed as described previously [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

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IOX1 impedes host inflammation in imiquimod-triggered psoriasis

Shin

Lee

Gharbi³

et al. 2021

Heliyon

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Psoriasis is a chronic autoimmune disease with an unknown etiology and highly limited treatment strategies. The drugs currently used in the treatment of psoriasis are rarely recommended for long-term use owing to the serious side effects. Although different targets have been identified for controlling psoriasis, the role of epigenetic modifications as therapeutic targets is yet to be elucidated. Here, we investigated the therapeutic potential of 8-hydroxyquinoline-5-carboxylic acid (IOX1), a novel drug with a genetic target, in psoriasis. The daily topical administration of IOX1 in a mouse model of imiquimod (IMQ)-induced psoriatic inflammation reduced inflammatory reactions in the skin and lowered the PASI score. Furthermore, intraperitoneally injected IOX1 repressed the inflammatory status induced by IMQ in psoriatic mice by reducing the mRNA levels of pro-inflammatory cytokines, restoring splenocyte populations, and regulating macrophage polarization. Our findings indicate the remedial effects of IOX1 on dermatitis psoriasis and the potential of IOX1 as a therapeutic compound in psoriasis.

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Section: Methodsmentioning

confidence: 99%

“…For histopathological examination, five thick skin sections were cut, stained with H&E, and observed under a microscope [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

IOX1 impedes host inflammation in imiquimod-triggered psoriasis

Shin

Lee

Gharbi³

et al. 2021

Heliyon

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“…Myostatin, a negative feedback regulator of muscle growth, is generated by skeletal myofibers, circulates in the blood and signals back to the myofibers to suppress muscle growth ( 79 ). This regulatory function of myostatin on muscle mass is directly supported by animals lacking the myostatin gene ( 80 , 81 ), or animals treated with the myostatin inhibitor follistatin ( 82 ) or YK11 ( 83 ). Also in humans, mutations in the myostatin gene resulted in increased muscle mass and force development ( 84 ).…”

Section: Molecular Data Regarding Locomotor and Respiratory Muscle Dy...mentioning

confidence: 99%

Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF

Mangner,

Winzer,

Linke

et al. 2023

Front. Cardiovasc. Med.

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Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction. Alterations of the skeletal muscle contribute to exercise intolerance in HF. This review will provide a contemporary summary of the clinical and molecular alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and thereby differentiate the effects on locomotor and respiratory muscles, in particular the diaphragm. Moreover, current and future therapeutic options to address skeletal muscle weakness will be discussed focusing mainly on the effects of exercise training.

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“…3 Steroidal SARMs have also been developed, of which YK-11, or systematically (17α,20E)-17,20-[(1-methoxyethylidene) bis (oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester, is a partial agonist of the androgen receptor also capable of myostatin inhibition. [4][5][6] Though lacking safety studies, YK-11 has been identified as an undeclared component of nutritional supplements 7 and as such is advertised on the Internet, so that anti-doping organizations have to stay alert. Given the chemical instability of YK-11, 7,8 it is unlikely that unchanged drug can be detected in urine.…”

Section: Introductionmentioning

confidence: 99%

“…SARMs represent a diverse group of pharmacologically active substances that can be classified based on their structure as arylpropionamide‐, quinolinone‐, tetrahydroquinoline‐, and hydantoin‐based compounds 3 . Steroidal SARMs have also been developed, of which YK‐11, or systematically (17α,20 E )‐17,20‐[(1‐methoxyethylidene) bis (oxy)]‐3‐oxo‐19‐norpregna‐4,20‐diene‐21‐carboxylic acid methyl ester, is a partial agonist of the androgen receptor also capable of myostatin inhibition 4–6 …”

Section: Introductionmentioning

confidence: 99%

Detection of selective androgen receptor modulator YK‐11 in a doping control sample

Sobolevsky,

Kucherova,

Ahrens

2023

Drug Testing and Analysis

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Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis

Cited by 10 publications

References 21 publications

IOX1 impedes host inflammation in imiquimod-triggered psoriasis

IOX1 impedes host inflammation in imiquimod-triggered psoriasis

Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF

Detection of selective androgen receptor modulator YK‐11 in a doping control sample

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