Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women

Choi, Soo Jeong; Lee, Min Sung; Kang, Duk Hee; Ko, Gang Jee; Lim, Hee‐Sook; Yu, Byung; Park, Moo Yong; Kim, Jin Kuk; Kim, Chul-Hee; Hwang, Seung Duk; Kim, Jun Chul; Won, Chang Won; An, Won Suk

doi:10.3390/ijerph18147344

Cited by 8 publications

(4 citation statements)

References 42 publications

(64 reference statements)

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“…In patients with lower muscle mass, a high myostatin/SMI ratio may indicate that the myostatin level corrected for muscle mass is relatively high because myostatin secretion itself is low due to the lower muscle mass. In a previous report, the myostatin/SMI ratio in older Korean women was negatively associated with HGS [ 7 ] but the myostatin/SMI ratio was not presented as an indicator of sarcopenia in CKD in this study. The myostatin level was not correlated with eGFR, but the myostatin/SMI ratio was positively correlated with eGFR.…”

Section: Discussioncontrasting

confidence: 68%

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Indoxyl Sulfate Might Play a Role in Sarcopenia, While Myostatin Is an Indicator of Muscle Mass in Patients with Chronic Kidney Disease: Analysis from the RECOVERY Study

Lee

Han

Kim

et al. 2022

Toxins

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Serum myostatin and indoxyl sulfate (IS) levels increase with kidney function decline and may function as uremic toxins in chronic kidney disease (CKD)-related sarcopenia. Herein, we analyzed the association between serum myostatin and IS levels and sarcopenia in patients with CKD, by performing a post hoc analysis of baseline data extracted from the RECOVERY study (clinicaltrials.gov: NCT03788252) of 150 patients with CKD. We stratified patients into two groups according to the median value of myostatin (cutoff 4.5 ng/mL) and IS levels (cutoff 0.365 mg/dL). The proportion of patients with sarcopenia was higher in those with high IS levels but lower in those with high myostatin levels. The skeletal muscle mass index (SMI) and handgrip strength (HGS) were significantly lower in patients with high IS levels but significantly higher in patients with high myostatin levels. IS levels showed a negative correlation with glomerular filtration rate (GFR), SMI, and HGS. However, myostatin levels were positively correlated with SMI and HGS, but not with GFR. Sarcopenia was independently associated with age and IS level after adjustment. Increased levels of serum total IS might play a role in sarcopenia, while increased levels of serum myostatin are associated with muscle mass in patients with CKD.

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Section: Discussioncontrasting

confidence: 68%

“…However, a recent report showed that myostatin levels increased in patients with CKD who were balance-trained. In addition, myostatin levels were associated with increased lean mass [ 7 ]. This study aimed to assess the association between serum myostatin and IS levels and sarcopenia in patients with CKD.…”

Section: Introductionmentioning

confidence: 99%

Indoxyl Sulfate Might Play a Role in Sarcopenia, While Myostatin Is an Indicator of Muscle Mass in Patients with Chronic Kidney Disease: Analysis from the RECOVERY Study

Lee

Han

Kim

et al. 2022

Toxins

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“…The appendicular skeletal muscle index (ASMI) was defined as ASM (kg)/height 2 (m 2 ). Patients were classified as having low muscle mass when ASMI was <7 for men or 5.4 for women ( 17 , 18 ). According to the etiologic criteria of the Global Leadership Initiative on Malnutrition (GLIM) ( 19 ), we included gastrointestinal symptoms, reduced food intake, and inflammatory status.…”

Section: Methodsmentioning

confidence: 99%

Identification of cachexia in lung cancer patients with an ensemble learning approach

Jia,

Zhao,

et al. 2024

Front. Nutr.

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ObjectiveNutritional intervention prior to the occurrence of cachexia will significantly improve the survival rate of lung cancer patients. This study aimed to establish an ensemble learning model based on anthropometry and blood indicators without information on body weight loss to identify the risk factors of cachexia for early administration of nutritional support and for preventing the occurrence of cachexia in lung cancer patients.MethodsThis multicenter study included 4,712 lung cancer patients. The least absolute shrinkage and selection operator (LASSO) method was used to obtain the key indexes. The characteristics excluded weight loss information, and the study data were randomly divided into a training set (70%) and a test set (30%). The training set was used to select the optimal model among 18 models and verify the model performance. A total of 18 machine learning models were evaluated to predict the occurrence of cachexia, and their performance was determined using area under the curve (AUC), accuracy, precision, recall, F1 score, and Matthews correlation coefficient (MCC).ResultsAmong 4,712 patients, 1,392 (29.5%) patients were diagnosed with cachexia based on the framework of Fearon et al. A 17-variable gradient boosting classifier (GBC) model including body mass index (BMI), feeding situation, tumor stage, neutrophil-to-lymphocyte ratio (NLR), and some gastrointestinal symptoms was selected among the 18 machine learning models. The GBC model showed good performance in predicting cachexia in the training set (AUC = 0.854, accuracy = 0.819, precision = 0.771, recall = 0.574, F1 score = 0.658, MCC = 0.549, and kappa = 0.538). The abovementioned indicator values were also confirmed in the test set (AUC = 0.859, accuracy = 0.818, precision = 0.801, recall = 0.550, F1 score = 0.652, and MCC = 0.552, and kappa = 0.535). The learning curve, decision boundary, precision recall (PR) curve, the receiver operating curve (ROC), the classification report, and the confusion matrix in the test sets demonstrated good performance. The feature importance diagram showed the contribution of each feature to the model.ConclusionsThe GBC model established in this study could facilitate the identification of cancer cachexia in lung cancer patients without weight loss information, which would guide early implementation of nutritional interventions to decrease the occurrence of cachexia and improve the overall survival (OS).

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“…Brie y, we used the following equation: ASM = 0.193 × body weight (kg) + 0.107 × height (cm) -4.157 × sex (male: 1; female: 2) -0.037 × age (years)-2.631. ASMI was de ned as ASM (kg)/height 2 (m 2 ) (Choi et al, 2021). Low muscle mass was de ned as ASMI <7 kg/m 2 for males and <5.4 kg/m 2 for females.…”

Section: Assessmentsmentioning

confidence: 99%

Systemic Inflammation with Sarcopenia Predict Survival in Patients with Gastric

Liu¹,

Ruan²,

Ge³

et al. 2021

Preprint

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Objective: The levels of platelet-related inflammation indicators and sarcopenia have been reported to affect the survival of patients with cancer. To evaluate the prognostic influence of platelet count (PLT), platelet–lymphocyte ratio (PLR), and systemic immune inflammation index (SII), and SII combined with sarcopenia on the survival of patients with gastric cancer (GC).Methods: A total of 1131 patients with GC (811 men and 320 women, average age: 59.45 years) were evaluated. Receiver operating characteristic curves were used to determine the best cut-off values of PLT, PLR, and SII, and univariate and multivariate Cox risk regression models were used to evaluate whether SII is an independent predictor of overall survival (OS). The prognostic SS (SII-sarcopenia) was established based on SII and sarcopenia. Finally, a comprehensive analysis of the prognostic SS was performed. Results: SII had the strongest prognostic effect. The SII and OS of patients with GC were in an inverted U-shape (adjusted HR = 1.06; 95% CI: 0.95-1.18; adjusted P = 0.271). In patients with SII >1800, SII was negatively correlated with OS (adjusted HR = 0.57; 95% CI: 0.29-1.12; adjusted P = 0.102), however, there is no statistical difference. Interestingly, a high SS was associated with a poorer prognosis. The higher the SS score, the worse the OS (P<0.001).Conclusion: SII is an independent prognostic indicator of GC, and high SII is related to poor prognosis. A Higher SS score had worse survival. Thus, the prognostic SS is a reliable predictor of OS in patients with GC.

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Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women

Cited by 8 publications

References 42 publications

Indoxyl Sulfate Might Play a Role in Sarcopenia, While Myostatin Is an Indicator of Muscle Mass in Patients with Chronic Kidney Disease: Analysis from the RECOVERY Study

Indoxyl Sulfate Might Play a Role in Sarcopenia, While Myostatin Is an Indicator of Muscle Mass in Patients with Chronic Kidney Disease: Analysis from the RECOVERY Study

Identification of cachexia in lung cancer patients with an ensemble learning approach

Systemic Inflammation with Sarcopenia Predict Survival in Patients with Gastric

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