Myositis with tretinoin

All-Trans Retinoic Acid-Induced Focal Myositis, Synovitis, and Mononeuritis

“…2,4 Some have argued that the pathogenesis of ATRA-associated myositis falls within the spectrum of this aberrant inflammatory response. 6,10,11 In addition to myositis, our patient also experienced frank arthritis and foot drop. This, to our knowledge, is the first case of bona fide inflammatory arthritis in this context.…”

“…All patients had imaging studies for the diagnosis of their myositis, although only 1 patient was biopsied with specimen showing edema, focal necrosis of muscle fibers, and inflammatory cells infiltrating the endomyseum and perimyseum. 11 MRI was the most commonly used radiographic modality (9/12), with the hallmark finding of increased signal intensity of the muscle/ FIGURE 1. T2-weighted coronal MRI of the pelvis demonstrating increased signal involving the left gluteus maximus muscle (arrow) with extension into both the gluteus minimus and the piriformis muscle.…”

Treatment of Acute Promyelocytic Leukemia by Retinoids

“…Other side effects, including bone marrow necrosis [11], hypercalcemia [122], erythema nodosum [123], marked basophilia [124,125], severe myositis [126], Sweet syndrome [127,128], Fournier's gangrene (necrotizing fasciitis of the penis and scrotum) [129,130], thrombocytosis [131], and necrotizing vasculitis [132] have rarely been reported with ATRA treatment.…”

A case of all-trans retinoic acid-induced myositis in the treatment of acute promyelocytic leukaemia

“…ATRA‐induced myositis as an adverse reaction is rare. From our current literature review, there have only been five publications involving seven patients with ATRA‐induced myositis (Miranda et al. , 1994; Christ et al.…”