Myositis-specific autoantibodies and their clinical associations in idiopathic inflammatory myopathies: results from a cohort from China

Wen, Lihong; Chen, Xin; Cheng, Qi; Xu, Jieying; Yan, Tingting; Zhang, Xin; Yang, Huanhuan; Sun, Wenjia; Liu, Lei; Xue, Jing; Du, Yan

doi:10.1007/s10067-022-06291-z

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…It has been stated the heterogeneity existed among distinct anti‐ARS antibodies 29 . Both anti‐Ro52 antibodies and any anti‐ARS antibodies were pertinent to clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognostic analysis of idiopathic inflammatory myopathy with positive anti‐aminoacyl‐tRNA synthetase antibodies: A single center experience

Zhang,

Wang,

Zhou

et al. 2023

Immunity Inflam & Disease

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ObjectivesTo identify the differences of clinical characteristics, laboratory findings, and the long‐term outcomes in patients with anti‐synthetase syndrome (ASS) of different anti‐aminoacyl‐transfer RNA synthetase antibodies.MethodsWe retrospectively enrolled 119 patients with ASS, and the clinical characteristics and laboratory findings were collected. Additionally, multivariate COX regression analysis was performed to estimate the risk factors of prognosis in patients with ASS.ResultsThe frequency of interstitial lung disease (ILD) reached 93.3% in our cohort, of 28 (23.5%) was classified as rapidly progressive (RP)‐ILD. The highest incidence of RP‐ILD was 36.4% in the PL12 group of ASS patients. The ILD group was characterized by an older age, a lower prevalence of V sign, and a higher prevalence of pulmonary symptoms when contrasted with the non‐ILD group. There were statistical differences of clinical significance in arthritis, myositis, mechanic's hands, triad, shawl sign, V sign, and Raynaud's phenomenon among the four subgroups (all p < .05). Additionally, the prevalence rates of arthritis, myositis, mechanic's hands, triad, and V sign in the anti‐Jo1 antibody‐positive group were significantly higher than anti‐Jo1 antibody‐negative patients with ASS (all p < .05). Multivariate Cox regression analysis showed mechanic's hands (odds ratio [OR] = 6.47, p < .001), anti‐nuclear antibodies (ANA) (OR = 2.13, p = .026), ILD (OR = 10.50, p < .001), and V sign (OR = 0.30, p = .007) were independent factors affecting the prognosis of patients with ASS. The incidences of RP‐ILD, arthritis, myositis, triad, mechanic's hands, and shawl sign were more frequent in the anti‐Ro52 antibody‐positive group than the anti‐Ro52 antibody‐negative patients with ASS (all p < .05).ConclusionsPatients with ASS accompanied with ILD are highly prevalent. Mechanic's hands, ANA, and ILD may be a potential biomarker for predicting a poor prognosis in patients with ASS. Additionally, the detection of the anti‐Ro52 antibody provides valuable insights for managing and predicting disease progression and long‐term outcomes.

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“…It has been stated the heterogeneity existed among distinct anti‐ARS antibodies 29 . Both anti‐Ro52 antibodies and any anti‐ARS antibodies were pertinent to clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognostic analysis of idiopathic inflammatory myopathy with positive anti‐aminoacyl‐tRNA synthetase antibodies: A single center experience

Zhang,

Wang,

Zhou

et al. 2023

Immunity Inflam & Disease

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“…A summary of relevant studies, including the current report from Lv et al, is given in the Table. 3,4,[7][8][9][10][11][12][13][14][15] All but 1 study 3 found that the presence of anti-Ro52 with anti-Jo1 was associated with more severe ILD and poorer outcomes. Notably similar findings were reported in a large cohort of children with juvenile myositis in the United States, where ILD is far less common.…”

mentioning

confidence: 95%

“…10 Further, in recent studies of 3 separate large Chinese cohorts, the combination of anti-Ro52 with anti-MDA5 was associated with either more frequent RP-ILD, poorer outcome, and/or higher mortality. [13][14][15] Also of interest is a Japanese prospective study of interstitial pneumonia, where patients with CTD were excluded and those with anti-Ro52 alone had worse survival. 11 So, despite the variability between studies in the patient populations, and the potential for bias already alluded to in what are mostly retrospective studies, there does seem to be solid evidence that the presence of anti-Ro52 is a poor prognostic indicator in IIM.…”

mentioning

confidence: 99%

Ro52, Myositis, and Interstitial Lung Disease

McHugh

2022

J Rheumatol

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“…However, the prevalence and risk factors of lung cancer in elderly DM patients are largely unclear in China. Recent studies have showed that myositis specific antibodies (MSA) are highly specific biomarkers and are closely related to unique clinical manifestations of IIM 8,9 . Several “cancer‐associated” autoantibodies such as anti‐translation initiation factor (TIF)‐1γ, anti‐small ubiquitin‐like modifier enzyme (SAE) and antinuclear matric protein (NXP2) may help identifying the risk for cancer in DM patients 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have showed that myositis specific antibodies (MSA) are highly specific biomarkers and are closely related to unique clinical manifestations of IIM. 8 , 9 Several “cancer‐associated” autoantibodies such as anti‐translation initiation factor (TIF)‐1γ, anti‐small ubiquitin‐like modifier enzyme (SAE) and antinuclear matric protein (NXP2) may help identifying the risk for cancer in DM patients. 10 , 11 However, evidence of a relationship between these biomarkers and lung cancer in elderly DM patients is limited.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and risk factors of lung cancer in elderly patients with dermatomyositis

Zhou

Dong-xing

et al. 2023

Thoracic Cancer

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Background: Although there are concerns about the association between dermatomyositis (DM) and malignancy, the clinical features in elderly DM patients with lung cancer are largely unknown. Here, we elucidated the clinical features and risk factors of lung cancer in elderly DM patients. Methods: The data of elderly DM patients (≥65 years old) with or without lung cancer admitted to the Second Xiangya Hospital, Central South University from January 2016 to November 2022 were retrospectively analyzed. Results: Male patients with elderly onset DM (EODM) symptoms were found to be prone to lung cancer (p < 0.001). Elderly DM patients with lung cancer had a higher ratio of a history of smoking and were more likely to present with heliotrope rash, V sign and dysphasia and elevated monocyte-to-lymphocyte ratio (MLR) and there was a higher ratio of anti-TIF1-γ-Ab-positive patients (all p < 0.05). Occurrence of interstitial lung disease (ILD), elevated aspartate aminotransferase (AST) and anti-aminoacyl-tRNA synthetase (anti-ARS)-antibody positive rates were less common in elderly DM patients with lung cancer than those without lung cancer (all p < 0.05). Multivariate logistic regression analysis showed smoking history (p = 0.011, OR = 4.532), elevated MLR (p = 0.018, OR = 1.159) and anti-TIF1-γ-Ab-positive status (p = 0.034, OR = 8.529) were independently associated with the presence of lung cancer, while ILD might be a protective factor (p = 0.024, OR = 0.179) for lung cancer in elderly patients with DM. Conclusions: Lung cancer is more common in male patients with EODM symptoms. Smoking, elevated MLR and being anti-TIF1-γ-Ab-positive were associated with higher frequencies of lung cancer in elderly DM patients. It is necessary to screen lung cancer in elderly DM patients with a history of smoking, elevated MLR or being anti-TIF1-γ-Ab-positive.

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Myositis-specific autoantibodies and their clinical associations in idiopathic inflammatory myopathies: results from a cohort from China

Cited by 8 publications

References 30 publications

Clinical characteristics and prognostic analysis of idiopathic inflammatory myopathy with positive anti‐aminoacyl‐tRNA synthetase antibodies: A single center experience

Clinical characteristics and prognostic analysis of idiopathic inflammatory myopathy with positive anti‐aminoacyl‐tRNA synthetase antibodies: A single center experience

Ro52, Myositis, and Interstitial Lung Disease

Clinical features and risk factors of lung cancer in elderly patients with dermatomyositis

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