Myosite, hypothyroïdie et fibrates

Acute Renal Failure After Cardiopulmonary Bypass: A Possible Association With Drugs of the Fibrate Group

“…Similarly, in hypoproteinemic states such as nephrotic syndrome, the risk of fibrate-induced myopathy is increased (17,18), because less protein is available to bind the active metabolites, thus increasing the levels of free active drug (13). Hypothyroidism is also believed to increase the risk of development of myopathy in association with fibrates (19)(20)(21)(22). There was no clinical evidence of hypothyroidism in any of our patients, and one (patient 1, who developed rhabdomyolysis) had documented normal thyroid function tests 6 months previously.…”

“…Normal range for urea (2.5-8 mmol/L), creatinine (60-110 wmol/L), CK (30-250 IU/L in males and 30-180 in females). [BUN: [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] mg/dl, creatinine: 0.6-1.2 mg/dl] Note that, in all patients, isoform analysis showed low proportions (<15%) of CK-MB, indicating that the increased activity reflected skeletal muscle damage. *CAVH, Continuous Arteriovenous Hemofiltration.…”