Myosin heavy chain profiles and body composition are different in old versus young Standardbred mares

Lehnhard, Robert A.; McKeever, Kenneth H.; Kearns, Charles F.; Beekley, Matthew D.

doi:10.1016/s1090-0233(03)00045-5

Cited by 33 publications

(21 citation statements)

References 47 publications

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“…Surveys have shown that age causes changes in muscle fiber types of MyHC isoform patterns and oxidative potential in horse skeletal muscle (Dingboom et al, 2002;Lehnhard et al, 2004). Horses older than 20 years had significantly less of type I and type IIA fibers in skeletal Leisson, Alev, Kaasik, Jaakma and Seene muscle and more of type IIx fibers than the young horses (Lehnhard et al, 2004;Kim et al, 2005). This study did not reveal any significant changes in the relative content of MyHC isoforms in skeletal muscle between the three age groups.…”

Section: Discussioncontrasting

confidence: 55%

“…Later, it was shown that the muscle fiber composition of horses ,20 years does not differ from that of young ones. In old horses, skeletal muscle was found to be significantly less in type I and type IIA fibers in comparison with younger ones (Lehnhard et al, 2004;Kim et al, 2005).…”

Section: Introductionmentioning

confidence: 81%

“…It has been previously shown that muscle fibers with high oxidative potential have higher resistance and capacity for regeneration during and after exercise (Votion et al, 2007;Seene et al, 2008 and. Surveys have shown that age causes changes in muscle fiber types of MyHC isoform patterns and oxidative potential in horse skeletal muscle (Dingboom et al, 2002;Lehnhard et al, 2004). Horses older than 20 years had significantly less of type I and type IIA fibers in skeletal Leisson, Alev, Kaasik, Jaakma and Seene muscle and more of type IIx fibers than the young horses (Lehnhard et al, 2004;Kim et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Though the percentages found in specific breeds differ among the studies, the highest amount of slow fibers are found to be represented in Arab horses (Rivero and Diz, 1992;Gondim et al, 2005). Studies with Standardbred horses (Roneus et al, 1992;Roneus, 1993;Lehnhard et al, 2004) have shown that this breed can have similar proportions of muscle fiber types compared to Arabs as well as to Thoroughbreds (Roneus et al, 1991;Rivero and Diz, 1992;Rivero et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

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Myosin heavy chain pattern in the Akhal-Teke horses

Leisson

Alev

Kaasik

et al. 2011

Animal

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This study investigates the myosin heavy chain (MyHC) isoform composition in the gluteus medius muscle of the Akhal-Teke horses using SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). Fifteen horses aged between 1.5 and 23.5 years were used in this study and divided into three age groups: 1.5 to 4 (n= 6), 9 to 13 (n= 5) and 18.5 to 23.5 years (n= 4). The average content of the MyHC I isoform was 11.72 ± 1.07% (variation between individuals: 7.09% to 20.14%). The relative content of the MyHC IIa and IIx isoforms was subsequently 38.20 ± 1.46% (30.73% to 48.78%) and 50.07 ± 1.10% (43.8% to 56.78%) from the total MyHC. The MyHC pattern in the skeletal muscles of the Akhal-Teke horses shows that the muscles of these horses have a high capacity both for endurance and speed.

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Myosin heavy chain pattern in the Akhal-Teke horses

Leisson

Alev

Kaasik

et al. 2011

Animal

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“…Energy requirements can decrease as older animals become less active and lose BM, and the maintenance demands of altered muscle metabolism decline as a consequence of sarcopenic and muscle fiber type changes. 8 Anorexia with consequent weight loss can often be directly related to dental or musculoskeletal disease, or where animals are maintained in group situations, a reduction of social hierarchy. Decreased fiber digestibility has been noted in older animals, and long fibers and whole cereal may be seen in the feces.…”

Section: Food Intakementioning

confidence: 99%

Nutritional Management of the Older Horse

Argo

2016

Veterinary Clinics of North America: Equine Practice

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The potential of three whole blood microRNAs to predict outcome and monitor treatment response in sarcoid-bearing equids

et al. 2022

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MicroRNAs (miRNAs) have been proposed as biomarkers for equine sarcoid (ES) disease. In this study, the suitability of three whole blood miRNAs to diagnose ES and to predict and monitor the outcome of therapy was explored. Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), expression levels of eca-miR-127, eca-miR-379, and eca-miR-432 in whole blood of ES-affected equids before and at least one year after therapy were compared to those of unaffected control equids. Associations of age, sex, species, diagnosis, and therapy outcome with miRNA expression levels were examined using general linear models. In total, 48 ES-affected equids and 47 control equids were recruited. From the affected animals, 31 responded favorably to treatment, and 17 demonstrated a failure of therapy. None of the tested miRNAs were influenced by age. Male equids showed increased expression of eca-miR-127 compared to females and horses showed higher expression levels of eca-miR-379 and eca-miR-432 than donkeys. Eca-miR-127 was confirmed as a diagnostic discriminator between ES-affected and control equids. No difference in miRNA profiles before therapy was found when comparing ES-affected equids with success vs. failure of therapy. Eca-miR-379 and eca-miR-432 decreased over time in horses where therapy was successful, but not in those cases where it failed. Biological variables influence equine whole blood miRNA expression, which may complicate biomarker validation. While none of the tested miRNAs could predict the response to therapy in ES-affected equids and eca-miR-127 showed poor diagnostic accuracy for ES, eca-miR-379 and eca-miR-432 miRNAs might allow refinement of monitoring of success of ES therapy.

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Myosin heavy chain profiles and body composition are different in old versus young Standardbred mares

Cited by 33 publications

References 47 publications

Myosin heavy chain pattern in the Akhal-Teke horses

Myosin heavy chain pattern in the Akhal-Teke horses

Nutritional Management of the Older Horse

The potential of three whole blood microRNAs to predict outcome and monitor treatment response in sarcoid-bearing equids

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