Myopia: Why Study the Mechanisms of Myopia? Novel Approaches to Risk Factors Signaling Eye Growth- How Could Basic Biology Be Translated into Clinical Insights? Where Are Genetic and Proteomic Approaches Leading? How Does Visual Function Contribute to and Interact with Ametropia? Does Eye Shape Matter? Why Ametropia at All?

Тарутта, Е. П.; Chua, Wei Ling; Young, Terri L.; Goldschmidt, Ernst; Saw, Seang‐Mei; Rose, Kathryn A.; Smith, Earl L.; Mutti, Donald O.; Ashby, Regan; Stone, Richard A.; Wildsoet, Christine F.; Howland, Howard C.; Fischer, Andy J.; Stell, William K.; Reichenbach, Andreas; Frost, Michael R.; Gentle, Alex; Zhu, Xiaoying; Summers-Rada, Jody; Barathi, Veluchamy A; Jiang, Liqin; McFadden, Sally A; Guggenheim, Jeremy A.; Hammond, Christopher J.; Schippert, Ruth; To, Chi‐Ho; Gwiazda, Jane; Marcos, Susana; Collins, Michael J.; Charman, W. N.; Artal, Pablo; Tabernero, Juan; Atchison, David A.; Seidemann, Anne; Uttenweiler, Dietmar; Troilo, David; Norton, Thomas T.; Wallman, Josh

doi:10.1097/opx.0b013e31820e6a6a

Cited by 10 publications

(8 citation statements)

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“…148 The progression of myopia has also slowed down with orthokeratology lens wear, in which the cornea is reshaped 149 and with the wear of specially designed multifocal contact lenses. 146,150 It seems that the rates of myopia progression can be reduced by up to 0.50 D over a period of 2 years using certain contact lens or spectacle lens designs compared with a control groups wearing single vision lenses; however, future studies are required to determine long-term changes in young myopes. 138,150,151 CONCLUSIONS This article has reviewed the prevalence of different levels of myopia in populations worldwide.…”

Section: Reducing the Rate Of Myopia Progressionmentioning

confidence: 97%

“…[143][144][145][146][147] The attempt to control peripheral hyperopic defocus with special lens designs has found success in children with a parental history of myopia and in girls 6 to 12 years of age but not in children over the age of 12. 148 The progression of myopia has also slowed down with orthokeratology lens wear, in which the cornea is reshaped 149 and with the wear of specially designed multifocal contact lenses.…”

Section: Reducing the Rate Of Myopia Progressionmentioning

confidence: 99%

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The Prevalence and Impact of High Myopia

Jones

Luensmann

2012

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Myopia has gained increasing interest in recent years, particularly because of its increase in prevalence across populations worldwide. The onset of myopia has shifted to a younger age, and the number of high myopes with prescriptions of more than -5.00 D has increased over the last few decades. High myopia is strongly associated with a greater incidence of pathologic complications, has shown to impact vision-related quality of life in children and adults and is further associated with certain contact lens complications. Different pharmaceutical and optical treatment options are currently under investigation with a common goal to slow down the rate of myopia progression.

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Section: Reducing the Rate Of Myopia Progressionmentioning

confidence: 97%

Section: Reducing the Rate Of Myopia Progressionmentioning

confidence: 99%

The Prevalence and Impact of High Myopia

Jones

Luensmann

2012

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Whenever one might be tempted to think that progress in myopia research has been slow, consider that the number of markers that constituted genome-wide scanning has grown in about 5 years from under 1,000 to over 1,000,000. The particular strength of these two reports in Nature Genetics (papers in Tübingen by Hysi et al and Klaver et al with abstracts in the IMC Symposium Summaries paper in this OVS issue) 6 is that the finding from one discovery sample was replicated in a separate sample. Single nucleotide polymorphisms on 15q25 and 15q14 were associated with refractive error.…”

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confidence: 94%

“…Ashby et al presented evidence that a light-induced retinal dopamine release may be the mechanism behind this effect. 6 Neitz and Neitz presented an intriguing theory that the more predominantly blue spectral composition of light outdoors, in conjunction with variation in retinal cone opsin genes, could influence refractive error. 6 Several papers in this issue of OVS address the effect of time outdoors.…”

mentioning

confidence: 98%

“…6 Neitz and Neitz presented an intriguing theory that the more predominantly blue spectral composition of light outdoors, in conjunction with variation in retinal cone opsin genes, could influence refractive error. 6 Several papers in this issue of OVS address the effect of time outdoors. An alternate theory for the effect of time outdoors is that increased levels of vitamin D may be protective.…”

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confidence: 98%

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13th International Conference on Myopia

Mutti

Schaeffel

Feldkaemper

2011

Optometry and Vision Science

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The combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia

Ritchey

Zelinka

Tang

et al. 2012

Experimental Eye Research

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Different growth factors have been shown to influence the development of form-deprivation myopia and lens-induced ametropias. However, growth factors have relatively little effect on the growth of eyes with unrestricted vision. We investigate whether the combination of insulin-like growth factor 1 (IGF1) and fibroblast growth factor 2 (FGF2) influence ocular growth in eyes with unrestricted vision. Different doses of IGF1 and FGF2 were injected into the vitreous chamber of postnatal chicks. Measurements of ocular dimensions and intraocular pressure (IOP) were made during and at the completion of different treatment paradigms. Histological and immunocytochemical analyses were performed to assess cell death, cellular proliferation and integrity of ocular tissues. Treated eyes had significant increases in equatorial diameter and vitreous chamber depth. With significant variability between individuals, IGF1/FGF2-treatment caused hypertrophy of lens and ciliary epithelia, lens thickness was increased, and anterior chamber depth was decreased. Treated eyes developed myopia, in excess of 15 diopters of refractive error. Shortly after treatment, eyes had increased intraocular pressure (IOP) which was increased in a dose-dependent manner. Seven days after treatment with IGF1 and FGF2 changes to anterior chamber depth, lens thickness and elevated IOP were reduced, whereas increases in the vitreous chamber were persistent. Some damage to ganglion cells was detected in peripheral regions of the retina at 7 days after treatment. We conclude that the extreme myopia in IGF1/FGF2-treated eyes results from increased vitreous chamber depth, decreased anterior chamber depth, and changes in the lens. We propose that factor-induced ocular enlargement and myopia result from changes to the sclera, lens and anterior chamber depth.

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Cited by 10 publications

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The Prevalence and Impact of High Myopia

The Prevalence and Impact of High Myopia

13th International Conference on Myopia

The combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia

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