Myopia Control with a Novel Peripheral Gradient Soft Lens and Orthokeratology: A 2-Year Clinical Trial

Pauné, Jaume; Morales, Hari; Armengol, Jesús; Quevedo, Lluı̈sa; Faria‐Ribeiro, Miguel; González-Meijóme, José Manuel

doi:10.1155/2015/507572

Cited by 110 publications

(131 citation statements)

References 34 publications

Supporting

Mentioning

121

Contrasting

Order By: Relevance

“…Between 2011 and 2019, 9 randomised trials with soft dual focus contact lenses were published . Four studies used lenses with a concentric design; the other studies used lenses with a progressive design.…”

Section: Myopia Managementmentioning

confidence: 99%

Myopia management in the Netherlands

Klaver

Polling

2020

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

Purpose A trend that myopia is becoming gradually more common is shown in studies worldwide. Highest frequencies have been found in East Asian urban populations (96.5%) but also a study in Europe shows that nearly half of the 25‐29 year olds has myopia. With the increase in prevalence, high myopia, i.e. a spherical equivalent of ‐6 or more and an axial length of 26 mm or more is also on the rise. High myopia particularly carries a significant risk of ocular pathology related to the long axial length. This highlights the need for myopia management in children with progressive myopia, in particular progression to high myopia. Recent findings During the last decade, many intervention studies for myopia progression have emerged. Although lifestyle adjustments are effective, pharmacological and optical interventions have shown the highest efficacy on reduction of eye growth. High concentration atropine (0.5%‐1.0%) shows the most reduction in axial length progression, but has drawbacks of light sensitivity and loss of accommodation. Nevertheless, when these side effects are mitigated by multifocal photochromatic glasses, the long‐term adherence to high dose atropine is high. Lower concentrations of atropine are less effective, but have less side effects. Studies on optical interventions have reported reduction of progression for Ortho‐K and multifocal contact lenses, but are in need for replication in larger studies with longer duration. Summary The field of myopia management is rapidly evolving, and a position on the best approach for daily clinics is desirable. Over the last 10 years, our team of clinical researchers has developed a strategy which involves decision‐making based on age, axial length, position on the axial length growth chart, progression rate, risk of high myopia, risk profile based on lifestyle and familial risk, side effects, and individual preference. This personalised approach ensures the most optimal long‐term myopia control, and helps fight against visual impairment and blindness in the next generations of elderly.

show abstract

Section: Myopia Managementmentioning

confidence: 99%

Myopia management in the Netherlands

Klaver

Polling

2020

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

show abstract

“…Percent reduction in axial eye growth in subjects fitted with orthokeratology versus control subjects wearing spectacles or soft contact lenses from several studies. 40,47,[82][83][84][85][86][87][88] Subjects were followed for two years (blue solid bars) or five years (red striped bar).…”

Section: Myopia Controlmentioning

confidence: 99%

Optical changes and visual performance with orthokeratology

Nti

Berntsen

2020

Clinical and Experimental Optometry

View full text Add to dashboard Cite

Orthokeratology has undergone drastic changes since first described in the early 1960s. The original orthokeratology procedure involved a series of lenses to flatten the central cornea and was plagued by variable results. The introduction of highly oxygen‐permeable lens materials that can be worn overnight, corneal topography, and reverse‐geometry lens designs revolutionised this procedure. Modern overnight orthokeratology causes rapid, reliable, and reversible reductions in refractive error. With modern designs, patients can wear lenses overnight, remove them in the morning, and see clearly throughout the day without the need for daytime refractive correction. Modern reverse‐geometry lens designs cause central corneal flattening and mid‐peripheral corneal steepening that provides clear foveal vision while simultaneously causing a myopic shift in peripheral retinal defocus. The peripheral myopic retinal defocus caused by orthokeratology is hypothesised to be responsible for reductions in myopia progression in children fitted with these lenses. This paper reviews the changes in orthokeratology lens design that led to the reverse‐geometry orthokeratology lenses that are used today and the optical changes these lenses produce. The optical changes reviewed include changes in refractive error and their time course, high‐ and low‐contrast visual acuity changes, changes in higher‐order aberrations and visual quality metrics, changes in accommodation, and changes in peripheral defocus caused by orthokeratology. The use of orthokeratology for myopia control in children is also reviewed, as are hypothesised connections between orthokeratology‐induced myopic peripheral defocus and slowed myopia progression in children, and safety and complications associated with lens wear. A better understanding of the ocular and optical changes that occur with orthokeratology will be beneficial to both clinicians and patients in making informed decisions regarding the utilisation of orthokeratology. Future research directions with this lens modality are also discussed.

show abstract

“…147,148 Changes in axial elongation for contact lens MC studies correlate reasonably well with changes in myopia progression. 149,150 Results from 9 MC studies published over the last 8 years with OK 147,148,[151][152][153][154] and other contact lens types [154][155][156] have reported mean increases in axial length in the experimental and control groups over a 2-year period of 0.33 mm and 0.55 mm, respectively, accounting for an average MC effect of 41%. However, it should be noted that calculation of MC efficacy based on refractive error measurements tends to be slightly higher than that calculated based on axial length, 17,157 and thus, these two ways of calculating efficacy are not interchangeable.…”

Section: Sources Of Off-label Use Information Permitted By the Fdamentioning

confidence: 99%