Myopia

Baird, Paul N.; Saw, Seang‐Mei; Lança, Carla Costa; Guggenheim, Jeremy A.; Smith, Earl L.; Zhou, Xiangtian; Matsui, K; Wu, Pei-Chang; Sankaridurg, Padmaja; Chia, Audrey; Rosman, Mohamad; Lamoureux, Ecosse L.; Man, Ryan; He, Mingguang

doi:10.1038/s41572-020-00231-4

Cited by 379 publications

(324 citation statements)

References 299 publications

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“…Once myopia develops, myopia may continue to progress throughout childhood and adolescence [2]. Particularly, the prevalence of myopia and rate of myopic progression were higher in girls than in boys.…”

Section: Discussionmentioning

confidence: 99%

“…Myopia is the most common ocular disorder, with increasing prevalence in recent decades, predominantly in East Asia [1]. Myopia is a refractive condition that is usually attributed to excessive axial length (AL) elongation and mostly progresses during school ages, especially during growth spurts [2,3]. Using data from the Korean National Survey, Lyu et al [4] reported that a younger age at menarche was associated with an increased risk of severe myopia.…”

Section: Introductionmentioning

confidence: 99%

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Myopic Progression in Girls with Gonadotrophin-Releasing Hormone Agonist Treatment for Central Precocious Puberty

et al. 2021

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We sought to determine whether the myopic progression of patients with central precocious puberty (CPP) who were undergoing treatment differed from that of their healthy peers with normal pubertal onset and progression. Eighteen girls with CPP and 14 age-matched controls who underwent regular ophthalmic examinations for at least 1 year were included. All the CPP patients received a 3.75 mg leuprolide acetate depot subcutaneously every 28 days. The spherical equivalent (SE) and axial length (AL) for myopia progression and the pubertal parameters (height, body weight, body mass index, Tanner stage, and bone age) were compared between the two groups. Of 32 subjects with a mean age of 8.6 ± 0.7 years, the SEs and ALs did not differ at baseline between the two groups, which had similar weight and similar body mass index. After 1 year, both the CPP patients and controls showed myopic progression, with an average myopic shift of −0.73 ± 0.48 diopters (D) and AL elongation with a mean change of 0.44 ± 0.61 mm. The SE and AL changes over 1 year were greater in the controls than those in the CPP patients, which was not statistically significant (–0.85 ± 0.55 D vs. –0.64 ± 0.41 D and 0.55 ± 0.89 mm vs. 0.35 ± 0.22 mm, respectively). The change in AL correlated significantly with the change in the height (β = 0.691, p = 0.039). In this 1-year study, the CPP patients with treatments trended to show less myopic progression than the controls.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myopic Progression in Girls with Gonadotrophin-Releasing Hormone Agonist Treatment for Central Precocious Puberty

et al. 2021

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“…Second, early-onset myopia, which refers to myopia occurring before the age of 11 years, was not evaluated in current study, due to the limitations of sample size. 24 Third, based on existing sample size, the associations might not have the strength to achieve real results, especially for HM. Fourth, the biological function of these SNPs and its detailed effect on occurrence of myopia need to be deep investigated by further biological studies.…”

Section: Discussionmentioning

confidence: 99%

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

Zhou

Yang

et al. 2021

PGPM

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Background: Myopia has raised a predominant public concern among minors. A recent genome-wide association study (GWAS) identified six novel loci in Asian adults. Whether these genetic loci works for myopia in minors remains unknown and worthy of exploration. Methods: In order to validate the findings, here we performed a case-control study (600 myopia minors, 110 high myopia (HM) minors, and 800 non-myopia minors as controls) utilizing the TaqMan single nucleotide polymorphism (SNP) genotyping assays. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) was adopted. Results: The median ages in controls, myopia, and HM were 15.

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“…Myopia (short-or near-sightedness) is a widespread and costly eye disorder, affecting as many as 80À90% of young adults in some Asian cities [1,2]. It is a condition in which vision at a distance is blurred, so that myopic individuals (myopes) have to bring objects closer to see them clearly.…”

mentioning

confidence: 99%

“…Myopic vision can be corrected with prescription lenses or corneal refractive surgery, making vision clear at any distance; but this does not correct the underlying problem, excessive elongation of the eye along the visual axis, which increases the risk of more severe consequences including retinal detachment and visual impairment. Simple, safe, and effective therapies are needed, to prevent the onset and progression of unrestrained axial elongation [1,2].…”

mentioning

confidence: 99%

A new angle on myopia therapeutics: Not just a fishing expedition

Stell

2021

EBioMedicine

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Myopia

Cited by 379 publications

References 299 publications

Myopic Progression in Girls with Gonadotrophin-Releasing Hormone Agonist Treatment for Central Precocious Puberty

Myopic Progression in Girls with Gonadotrophin-Releasing Hormone Agonist Treatment for Central Precocious Puberty

Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors

A new angle on myopia therapeutics: Not just a fishing expedition

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