Myopericytoma in an unusual location

Ruiz-Arriaga, León Felipe; Terán, Ana Laura Ramírez; Ortíz-Hidalgo, Carlos; Fonte-Avalos, Verónica; Toussaint–Caire, Sonia; Vega-Memije, Ma Elisa; Anda-Juarez, Mariana CatalinaDe

doi:10.5070/d3244039361

Cited by 8 publications

(6 citation statements)

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“…Overall, the rate of recurrence has been reported to be 10%-20%. 25 Our single complication (case 15) was a locally aggressive form of myopericytoma, consistent with the patient's clinical progress. Despite our histopathological findings of a benign lesion, the presentation of rapid growth and infiltration may represent a malignant form of myopericytoma, which has been previously described in 2 cases by McMenamin and Fletcher.…”

Section: Discussionsupporting

confidence: 76%

“…These findings are consistent with recent reviews of cutaneous myopericytoma and numerous case reports. 9,20,[24][25][26] Owing to its rarity, it may not be commonly considered as a differential diagnosis by surgeons. Indeed, a review by Aung et al 24 noted clinical impressions by various case reports, including dermatofibrosarcoma, angioleiomyoma, angiolipoma, pyogenic granuloma, epidermal cyst, and squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Myopericytoma: A Review of Twenty-Three Cases Over Twelve Years and a Case Report of a Rare Neoplasm

Tan

Tay

Tang

et al. 2022

The American Journal of Dermatopathology

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:Myopericytoma is a rare soft tissue tumor with a predilection for the distal extremities. It is commonly found in the skin and subcutaneous tissues and usually takes a benign course. Current knowledge is limited to isolated case series and reports; hence, this study aims to report our tertiary institution's experience with this uncommon entity. A review of our institution's pathology records for cases of myopericytoma was performed. From January 2009 to September 2020, 23 cases of myopericytoma were identified and their clinicopathologic features were reported. A unique case of myopericytoma of the ankle from the series was also highlighted as a case report. Among the 22 cutaneous cases, 18 were in the extremities and 4 in the head and neck. One patient had an intracranial lesion. Most patients developed asymptomatic nodules (72.2%), but 1 patient had a locally aggressive tumor on presentation. None recurred despite marginal excision in some patients (80.0%). In conclusion, pathologists and surgeons who encounter this rare neoplasm can reassure patients of its benign tendency.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Myopericytoma: A Review of Twenty-Three Cases Over Twelve Years and a Case Report of a Rare Neoplasm

Tan

Tay

Tang

et al. 2022

The American Journal of Dermatopathology

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“…1 Immunohistological staining is positive for SMA and h-caldesmon. 5 These cells composing the thick vessel walls are generally negative for desmin and CD34, 7 as in our case.…”

Section: Discussionsupporting

confidence: 63%

“…5 Myopericytomas are typically slowgrowing neoplasms and are usually less than 2 cm in greatest dimension 6 and present as a painless discrete nodule with a gray-white colored appearance on physical examination. 7,8 These nodules can be found in a variety of areas within the body, including the neck, 9 trunk, 9 and nervous system. 10 Biopsy from the opposite thigh in our patient showed similar features, and multicentric cases have been reported.Excision biopsy is optimal for histopathological examination and immunophenotypic evaluation, 11 which shows nodular proliferation of concentric round or ovoid eosinophilic spindle cells with an onion skin pattern.…”

mentioning

confidence: 99%

Multiple Nodules on the Bilateral Lower Extremities: Answer

Deo

Mastin

Peters

et al. 2022

The American Journal of Dermatopathology

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ANSWERMyopericytomatosis. DISCUSSIONMyopericytoma (MPC) is a mesenchymal neoplasm of perivascular myoid cells, usually found in the subcutaneous tissue of the distal extremities, and most often presenting as a slow-growing nodule in men more than women. 1 These typically painless nodules generally develop during adulthood. 2 Although considered benign, MPC has been reported to recur after trauma. 3 These vascular proliferations contain ovoid spindle-shaped myopericytes that are only found in the dermis. 3 Myopericytomas are considered to represent a transition between pericytes and smooth muscle cells 3,4 that are able to differentiate into modified smooth muscle cells normally found in capillaries. 5 Myopericytomas are typically slowgrowing neoplasms and are usually less than 2 cm in greatest dimension 6 and present as a painless discrete nodule with a gray-white colored appearance on physical examination. 7,8 These nodules can be found in a variety of areas within the body, including the neck, 9 trunk, 9 and nervous system. 10 Biopsy from the opposite thigh in our patient showed similar features, and multicentric cases have been reported.Excision biopsy is optimal for histopathological examination and immunophenotypic evaluation, 11 which shows nodular proliferation of concentric round or ovoid eosinophilic spindle cells with an onion skin pattern. 5,6 Cases may have close resemblance to glomangioma or focal areas of glomangioma-like cytology. 1 Immunohistological staining is positive for SMA and h-caldesmon. 5 These cells composing the thick vessel walls are generally negative for desmin and CD34, 7 as in our case.The prognosis of MPC is generally favorable because it is usually benign. 8 However, some cases of malignant MPC have been reported. 6 Such lesions exhibit mitoses, necrosis, and nuclear atypia. 5 Symptomatic MPCs may be managed by excision. 5 The reported recurrence rate is 10%-20%. 5 Postoperative management includes surveillance in case of recurrence. 11

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“…Myopericytoma is characterized by a well‐circumscribed, nonencapsulated proliferation of spindle‐shaped cells resembling myofibroblasts with oval nuclei and eosinophilic cytoplasm, arranged in perivascular concentric rings. Few mitoses are observed, and no necrosis has been reported 18 . Histopathological differentiation was established between the condition in this case and the aforementioned four diseases.…”

Section: Discussionmentioning

confidence: 55%

Myopericytoma in an unusual location

Cited by 8 publications

References 0 publications

Myopericytoma: A Review of Twenty-Three Cases Over Twelve Years and a Case Report of a Rare Neoplasm

Myopericytoma: A Review of Twenty-Three Cases Over Twelve Years and a Case Report of a Rare Neoplasm

Multiple Nodules on the Bilateral Lower Extremities: Answer

Relationship between dermoscopic and histopathological findings of extradigital glomus tumors

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