Myopericytoma and arterial intimal thickening: the relationship between myopericytes and myointimal cells

Díaz‐Flores, Lucio; Gutiérrez, Ricardo; García, Maria Pino; Álvarez‐Argüelles, Hugo; Madrid, Juan Francisco

doi:10.1111/j.1600-0560.2011.01778.x

Cited by 12 publications

(3 citation statements)

References 41 publications

(53 reference statements)

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“…Thus, activation may occur with myofibroblast differentiation (greater proximity) or without immunophenotypic transformation to myofibroblasts (greater distance). In previous works, we described the activation of CD34+ stromal cells without transformation to myofibroblasts in some processes, such as in vocal folds affected by Reinke's edema (Díaz‐Flores et al, 2013), in tissues around silicon prosthesis (Díaz‐Flores, et al, ), and in some tumoral capsules (Díaz‐Flores, et al, ). Therefore, repair after injury may occur with myofibroblast differentiation or without immunophenotypic transformation to myofibroblasts.…”

Section: Discussionmentioning

confidence: 95%

Behavior ofIn SituHuman Native Adipose TissueCD34+ Stromal/Progenitor Cells During Different Stages of Repair. Tissue‐ResidentCD34+ Stromal Cells as a Source of Myofibroblasts

Díaz‐Flores

Gutiérrez

Lizartza

et al. 2014

The Anatomical Record

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CD341 adipose stromal cells are scattered in the adipose tissue and found in the CD341 population of the stromal vascular fraction (SVF). This fraction includes adipose-derived stromal/stem/progenitor cells (ASCs), which have attracted considerable attention and show great promise for the future of regenerative medicine. Studies in this field have been undertaken mainly in vitro. In this work, however, we assessed the characteristics of human adipose tissue-resident CD341 stromal cells in normal conditions and when activated in vivo during inflammatory/repair processes at different stages of evolution. In normal adipose tissue, these cells showed a characteristic location (peri/paravascular and between adipocytes), a fusiform or stellate morphology, long and moniliform processes, and scarce organelles. During inflammatory/repair stages, native CD341 stromal cells increased in size, proliferated, developed numerous organelles of synthesis, lost CD34 expression, and differentiated into myofibroblasts (aSMA expression and typical ultrastructure). In double-stained sections, cells expressing both CD34 and aSMA were observed. CD34 expression correlated positively with a high proliferative capacity (Ki-67 expression). Conversely, CD34 expression was lost with successive mitoses and with increased numbers of macrophages in the granulation tissue. CD341 stromal cell behavior varied depending on proximity to (with myofibroblast differentiation) or remoteness from (with activated plump cells conserving CD34 expression) injury. In conclusion, our observations point to human adipose tissue-resident CD341 stromal cells as an important source of myofibroblasts during inflammatory/ repair processes. Moreover, stromal cell activation may occur with or without aSMA expression (with or without myofibroblast transformation) and with

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Section: Discussionmentioning

confidence: 95%

Behavior ofIn SituHuman Native Adipose TissueCD34+ Stromal/Progenitor Cells During Different Stages of Repair. Tissue‐ResidentCD34+ Stromal Cells as a Source of Myofibroblasts

Díaz‐Flores

Gutiérrez

Lizartza

et al. 2014

The Anatomical Record

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“…Next, diffuse immunoreactivity of these perivascular tumors to αSMA, MSA, and vimentin further solidified a pericytic identity, although highly nonspecific. 12-14 Finally, ultrastructural examination by transmission electron microscopy has suggested either a modified pericyte or smooth muscle phenotype in glomus tumor, 15-17 myopericytoma, 18 and angioleiomyoma. 19 However, a definite pericytic line of differentiation has remained undetermined across this spectrum of related tumors.…”

Section: Introductionmentioning

confidence: 99%

Pericyte Antigens in Perivascular Soft Tissue Tumors

et al. 2015

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Introduction Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes or modified perivascular cells. Among these, glomus tumor, myopericytoma, and angioleiomyoma share a spectrum of histologic findings and a perivascular growth pattern. In contrast, solitary fibrous tumor (previously termed hemangiopericytoma) was once hypothesized to have pericytic differentiation. Methods Here, we systematically examine pericyte immunohistochemical markers among glomus tumor (including malignant glomus tumor), myopericytoma, angioleiomyoma, and solitary fibrous tumor. Immunohistochemical staining and semiquantification was performed using well-defined pericyte antigens, including αSMA, CD146, and PDGFRβ. Results Glomus tumor and myopericytoma demonstrate diffuse staining for all pericyte markers, including immunohistochemical reactivity for αSMA, CD146, and PDGFRβ. Malignant glomus tumors all showed some degree of pericyte marker immunoreactivity, although it was significantly reduced. Angioleiomyoma shared a similar αSMA + CD146 + PDGFRβ+ immunophenotype; however, this was predominantly seen in the areas of perivascular tumor growth. Solitary fibrous tumors showed patchy PDGFRβ immunoreactivity only. Discussion In summary, pericyte marker expression is a ubiquitous finding in glomus tumor, myopericytoma, and angioleiomyoma. Malignant glomus tumor shows a comparative reduction in pericyte marker expression, which may represent partial loss of pericytic differentiation. Pericyte markers are essentially not seen in solitary fibrous tumor. The combination of αSMA, CD146, and PDGFRβ immunohistochemical stainings may be of utility for the evaluation of pericytic differentiation in soft tissue tumors.

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“…A review of the English literature was done in PubMed – the search was conducted with the word ‘myopericytoma’ for literature dating from 1998 to 2012 – and revealed 115 cases of MPC mainly from 5 papers and other case reports [1, 4, 5, 6, 7, 8]. MPC was slightly male predominant: the male to female ratio was 1.25:1.…”

Section: Discussionmentioning

confidence: 99%

Management of Multicentric Myopericytoma in the Maxillofacial Region: A Case Report

Sun

Dong

et al. 2013

Case Rep Oncol

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Myopericytoma (MPC) is a rare kind of benign neoplasm, showing derivation from perivascular myoid cells. About 115 cases have been reported in the English literature; however, most of the literature focuses on the description and classification of pathology. The case presented here is that of a 42-year-old woman with a surgical management experience of multicentric MPC in the maxillofacial region. Although small MPC can be completely and easily excised, large MPC, especially in certain anatomic sites, necessitates careful preoperative preparation.

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Myopericytoma and arterial intimal thickening: the relationship between myopericytes and myointimal cells

Cited by 12 publications

References 41 publications

Behavior ofIn SituHuman Native Adipose TissueCD34+ Stromal/Progenitor Cells During Different Stages of Repair. Tissue‐ResidentCD34+ Stromal Cells as a Source of Myofibroblasts

Behavior ofIn SituHuman Native Adipose TissueCD34+ Stromal/Progenitor Cells During Different Stages of Repair. Tissue‐ResidentCD34+ Stromal Cells as a Source of Myofibroblasts

Pericyte Antigens in Perivascular Soft Tissue Tumors

Management of Multicentric Myopericytoma in the Maxillofacial Region: A Case Report

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