Myopericarditis After mRNA COVID-19 Vaccine in a Patient With Recent History of COVID-19

Elhouderi, Eiman; EL-Sawalhy, Eman; Kabbani, Mohamed S.

doi:10.7759/cureus.25264

Cureus

2022

DOI: 10.7759/cureus.25264

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Myopericarditis After mRNA COVID-19 Vaccine in a Patient With Recent History of COVID-19

Eiman Elhouderi¹,

Eman EL-Sawalhy²,

Mohamed S. Kabbani³

Abstract: Myopericarditis has been identified as a potential adverse event of several vaccines in the medical literature.Here we present a case of a 30-year-old male who had myopericarditis a week after receiving the second booster dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. The patient's clinical course was not severe and had a full recovery after a week of treatment.

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2023

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Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases

Saputra¹,

Kurniawan²,

Trilistyoati³

et al. 2023

Biomol Biomed

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Vaccination is significant to control, mitigate, and recover from the destructive effects of coronavirus disease 2019 (COVID-19). The incidence of myocarditis following COVID-19 vaccination has been increasing and growing public concern; however, little is known about it. This study aimed to systematically review myocarditis following COVID-19 vaccination. We included studies containing individual patient data of myocarditis following COVID-19 vaccination published between January 1, 2020 and September 7, 2022 and excluded review articles. Joanna Briggs Institute critical appraisals were used for risk of bias assessment. Descriptive and analytic statistics were performed. A total of 121 reports and 43 case series from five databases were included. We identified 396 published cases of myocarditis and observed that the majority of cases was male patients, happened following the second dose of mRNA vaccine administration, and experienced chest pain as a symptom. Previous COVID-19 infection was significantly associated (p < 0.01; OR, 5.74; 95% CI, 2.42–13.64) with the risk of myocarditis following the administration of the first dose, indicating that its primary mechanism is immune-mediated. Moreover, 63 histopathology examinations were dominated by non-infective subtypes. Electrocardiography and cardiac marker combination is a sensitive screening modality. However, cardiac magnetic resonance is a significant noninvasive examination to confirm myocarditis. Endomyocardial biopsy may be considered in confusing and severe cases. Myocarditis following COVID-19 vaccination is relatively benign, with a median length of hospitalization of 5 days, intensive care unit admission of <12%, and mortality of <2%. The majority was treated with nonsteroidal anti-inflammatory drugs, colchicine, and steroids. Surprisingly, deceased cases had characteristics of being female, older age, non-chest pain symptoms, first-dose vaccination, left ventricular ejection fraction of <30%, fulminant myocarditis, and eosinophil infiltrate histopathology.

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Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases

Saputra¹,

Kurniawan²,

Trilistyoati³

et al. 2023

Biomol Biomed

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Myopericarditis After mRNA COVID-19 Vaccine in a Patient With Recent History of COVID-19

Cited by 1 publication

References 17 publications

Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases

Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases

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