Myopathie hypothyroïdienne : à propos d'un cas avec élévation majeure de la créatine phosphokinase, myoglobinémie et insuffisance rénale transitoire

Gepner, P.; Botto, Henry; Piette, Anne–Marie; Graveleau, P.; Chapman, A.

doi:10.1016/s0248-8663(05)82222-2

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…Three cases of rhabdomyolysis caused by hypothyroidism have been reported in the literature [3][4][5]. In all cases rhabdomyolysis complicates long-term myxedema and is not an early sign of hypothyroidism.…”

Section: Discussionmentioning

confidence: 99%

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Exercise-induced myalgia in hypothyroidism

et al. 1993

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Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance spectroscopy of hypothyroid muscle shows low intracellular pH in resting muscle and delayed glycogen breakdown in exercising muscle [8]. Rhabdomyolysis is a uncommon sign of hypothyroid myopathy; three cases of rhabdomyolysis caused by hypothyroidism have been reported in the literature [3][4][5].…”

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confidence: 99%

Exercise-induced myalgia in hypothyroidism

et al. 1993

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Rhabdomyolysis: A review

2002

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Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis.

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A case of rhabdomyolysis with fatal outcome after a treatment with levofloxacin

Petitjeans

Perez

Debien

et al. 2003

European Journal of Clinical Pharmacology

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Fluoroquinolones are known to cause rhabdomyolysis. Levofloxacin is a recent fluoroquinolone and its muscular toxicity is not well documented. We describe the case of a 77-year-old female patient, who presented with an acute rhabdomyolysis after treatment with levofloxacin. She had a background of serious cardio-pulmonary disease. She received an oral ambulatory treatment with levofloxacin for pulmonary infection. After 6 days, she presented with severe rhabdomyolysis, resulting in complete anuria with hyperkalaemia, complicated with acute liver cytolysis and respiratory failure. The treatment was a daily repeated haemodialysis. She presented with a fatal myocardial infarction 13 days after admission. The medical history inclines us to strongly suspect levofloxacin as the cause of this severe adverse drug reaction. We also reviewed 27 other suspect cases reported in the database provided by the World Health Organization Collaborating Centre for Drug Monitoring (Uppsala, Sweden). We conclude that rhabdomyolysis can be a rare, severe adverse effect of levofloxacin, as well as the other fluoroquinolones.

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Myopathie hypothyroïdienne : à propos d'un cas avec élévation majeure de la créatine phosphokinase, myoglobinémie et insuffisance rénale transitoire

Cited by 9 publications

References 18 publications

Exercise-induced myalgia in hypothyroidism

Exercise-induced myalgia in hypothyroidism

Rhabdomyolysis: A review

A case of rhabdomyolysis with fatal outcome after a treatment with levofloxacin

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