Myometrial myxoidosis in a patient with systemic lupus erythematosus

Abstract

Myometrium myxoidosis is new terminology to describe a non-neo-plastic process of extracellular mucinous accumulation in the myometrium wall of the uterus. We report a rare association of myometrial myxoidosis with lupus erythematosus in a 35-year old woman with a history of leiomyoma. At presentation, this case was diagnosed as a pelvic abscess and treated with specific antibiotherapy, and then discharged after clinical improvement. One week later, after recurrence of the symptoms, the patient underwent hysterectomy with bilateral salpingo-oophorectomy and appendectomy with anterior abdominal soft tissue part resection. Pathological analysis revealed diffuse hypo-cellular myxoid areas intersecting the smooth muscle layer of the uterus and cervix in addition to a focal area in the interstitium of smooth muscles of the appendix and soft tissue of the anterior abdominal wall. This case emphasizes the importance of distinguishing between myxoid neoplastic and non-neoplastic lesions with myxoid changes. SIMILAR CASES PUBLISHED: To our knowledge, there are only two similar cases reported.

Intestinal Submucosal Mucinosis in a Patient With Systemic Lupus Erythematosus: A Case Report

“…Three cases of myometrial myxoidosis associated with SLE have been reported. 7,8 The mucin material is positive for Alcian blue staining at pH 2.5 and sensitive to hyaluronidase digestion, while mucicarmine staining is weakly positive. 7 The findings are suggestive of hyaluronic acid accumulation, the same result as cutaneous mucinosis.…”