Myomerger Induces Membrane Hemifusion and Regulates Fusion Pore Expansion
Ary Lautaro Di Bartolo,
Marcelo Caparotta,
Luis Mariano Polo
et al.
Abstract:Membrane fusion is a crucial mechanism in a wide variety of important events in cell biology from viral infection to exocytosis. However, despite many efforts and much progress, cell− cell fusion has remained elusive to our understanding. Along the life of the fusion pore, large conformational changes take place from the initial lipid bilayer bending, passing through the hemifusion intermediates, and ending with the formation of the first nascent fusion pore. In this sense, computer simulations are an ideal te… Show more
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