Myokines: metabolic regulation in obesity and type 2 diabetes
Zhi-Tian Chen,
Zhi-Xuan Weng,
Jiandie D Lin
et al.
Abstract:Skeletal muscle plays a vital role in the regulation of systemic metabolism, partly through its secretion of endocrine factors which are collectively known as myokines. Altered myokine levels are associated with metabolic diseases, such as type 2 diabetes (T2D). The significance of interorgan crosstalk, particularly through myokines, has emerged as a fundamental aspect of nutrient and energy homeostasis. However, a comprehensive understanding of myokine biology in the setting of obesity and T2D remains a major… Show more
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