Myoglobinuria, 1984

Rowland, Lewis P.

doi:10.1017/s031716710004525x

Cited by 37 publications

(9 citation statements)

References 181 publications

(136 reference statements)

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“…In a comatose patient, the first sign of rhabdomyolysis may be the onset of acute renal failure. 133 Acute renal failure due to rhabdomyolysis may also be a clue to illicit drug abuse when such a history is not volunteered.…”

Section: Trauma and Compressionmentioning

confidence: 99%

“…30 A protective estrogenic effect favors oxidative muscle metabolism, 18,112 whereas hypoestrogenemia following intensive training may predispose to rhabdomyolysis. 33 The protective effects of estrogen on muscle may account for the preponderance of affected males with inherited myoglobinuria, 133 and the postpartum presentation of certain necrotizing lipid storage myopathies. 81 Accordingly, women presenting with rhabdomyolysis after heat stroke should be investigated for underlying muscle disease or other exogenous factors such as toxin or drug ingestion.…”

Section: Hyperthermic Syndromesmentioning

confidence: 99%

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Rhabdomyolysis: A review

2002

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Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis.

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Section: Trauma and Compressionmentioning

confidence: 99%

Section: Hyperthermic Syndromesmentioning

confidence: 99%

Rhabdomyolysis: A review

2002

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“…The patient developed resistant rhabdomyolysis, which caused renal failure. Notably, rhabdomyolysis is implicated as the cause of approximately 5%–25% of cases of acute renal failure 6. There are two case reports in the literature worth mentioning.…”

Section: Discussionmentioning

confidence: 99%

Acute renal failure and severe rhabdomyolysis in a patient with resistant thrombotic thrombocytopenic purpura

Qahtani

2011

IJGM

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Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder. This paper describes the case of a 39-year-old Sudanese male who presented to the emergency room with fever, jaundice, decreased level of consciousness, and worsening kidney function for 7 days, a high lactate dehydrogenase level (1947), severe thrombocytopenia (platelets 8), and numerous schistocytes in the peripheral blood smear. The patient was admitted with a diagnosis of TTP for plasma exchange. Fourteen days later, his creatinine kinase (CK) level rose to >50,000 IU; rhabdomyolysis was suggested. Continuous venovenous hemodialysis (CVVHD) was started. The patient’s CK level remained high, despite CVVHD, until the 6th day, after which this parameter gradually started to decrease. This report highlights a resistant case of TTP that presented with concomitant severe rhabdomyolysis, which demanded aggressive, continuous intervention.

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“…Some authors defined rhabdomyolysis to include any condition in which serum CPK was 3-or 5-fold higher than normal. However, other authors defined a serum CPK level > 1000 IU/L in absence of myocardial infarction as rhabdomyolysis [1,[30][31][32]. Peak CPK levels were 297 IU/L (approximately 2.5-fold higher than normal) in case 1, 778 IU/L (approximately 6-fold higher than normal) in case 2, and 195 IU/L (approximately 1.5-fold higher than normal) in case 3.…”

Section: Discussionmentioning

confidence: 99%

RHABDOMYOLYSIS DUE TOEscherichia coliSEPSIS IN THREE PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Yılmaz

Demircioğlu

Ören

et al. 2009

Pediatric Hematology and Oncology

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Rhabdomyolysis with myoglobinuria is an uncommon complication of bacterial sepsis. The authors describe three pediatric acute lymphoblastic leukemia patients who developed rhabdomyolysis during a neutropenic sepsis episode due to Escherichia coli. All of the patients needed hemodynamic supportive treatment because of septic shock. Broad-spectrum antibiotics, alkalinization, and intravenous fluid therapy was given. One patient with renal insufficiency died, despite aggressive treatment. Muscle pain and dark urine color should alert physicians to the possibility of rhabdomyolysis in immunocompromised patients with sepsis. Early and appropriate treatment is critical in these patients to prevent renal failure and shock, and for a better outcome.

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Myoglobinuria, 1984

Cited by 37 publications

References 181 publications

Rhabdomyolysis: A review

Rhabdomyolysis: A review

Acute renal failure and severe rhabdomyolysis in a patient with resistant thrombotic thrombocytopenic purpura

RHABDOMYOLYSIS DUE TOEscherichia coliSEPSIS IN THREE PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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