Myogenic oxidative imbalance interferes with antral motility in obese subjects

Scirocco, Annunziata; Pallotta, Lucia; Rengo, Marco; Ignazzi, Antonia; Carabotti, Marilia; Cicenia, Alessia; Vona, Rosa; Chirletti, Piero; Maselli, M.A.; Donghia, Rossella; Coluzzi, Mariagrazia; Matarrese, Paola; Silecchia, Gianfranço; Severi, Carola

doi:10.1016/j.dld.2018.03.005

Cited by 3 publications

(2 citation statements)

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“…In this context, a recent study shows that DD patients' diet has a lower antioxidant content and a reduced oxygen radical absorbance capacity than healthy subjects 44 . Further, in ex‐vivo human models, antioxidants have been shown to revert the oxidative‐driven switch of SMCs to a synthetic myofibroblast‐like phenotype induced by LPS 39 and to improve impaired human antrum relaxation in obese patients 45 . Therefore, antioxidant supplementation may counteract disease progression.…”

Section: Discussionmentioning

confidence: 99%

“…44 Further, in ex-vivo human models, antioxidants have been shown to revert the oxidative-driven switch of SMCs to a synthetic myofibroblast-like phenotype induced by LPS 39 and to improve impaired human antrum relaxation in obese patients. 45 Therefore, antioxidant supplementation may counteract disease progression. Furthermore, the recent demonstration that circulating serological markers reflect tissue oxidative imbalance in the different clinical phenotypes of DD 37 provides a valuable tool to monitor disease progression and validate targeted therapeutic strat-…”

Section: Discussionmentioning

confidence: 99%

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From diverticulosis to complicated diverticular disease: Progression of myogenic alterations and oxidative imbalance

Pallotta,

Pisano,

Vona

et al. 2024

Neurogastroenterology Motil

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BackgroundThe natural history and pathophysiology of diverticular disease (DD) are still uncertain. An ex‐vivo human complicated DD (cDD) model has recently shown a predominant transmural oxidative imbalance. The present study aims to evaluate whether the previously described alterations may precede the symptomatic form of the disease.MethodsColonic surgical samples obtained from patients with asymptomatic diverticulosis (DIV), complicated DD, and controls were systematically and detailed morphologically and molecularly analyzed. Therefore, histologic, histomorphometric, immunohistochemical evaluation, and gene and protein expression analysis were performed to characterize colonic muscle changes and evaluate chronic inflammation, oxidative imbalance, and hypoxia. Functional muscle activity was tested on strips and isolated cells in response to contractile and relaxant agents.Key ResultsCompared with controls, DD showed a marketed increase in muscle layer thickness, smooth muscle cell syncytium disarray, and increased interstitial fibrosis; moreover, the observed features were more evident in the cDD group. These changes mainly affected longitudinal muscle and were associated with altered contraction‐relaxation dynamics and fibrogenic switch of smooth muscle cells. Chronic lymphoplasmacytic inflammation was primarily evident in the mucosa and spared the muscle. A transmural increase in carbonylated and nitrated proteins, with loss of antioxidant molecules, characterized both stages of DD, suggesting early oxidative stress probably triggered by recurrent ischemic events, more pronounced in cDD, where HIF‐1 was detected in both muscle and mucosa.Conclusion & InferencesThe different DD clinical scenarios are part of a progressive process, with oxidative imbalance representing a new target in the management of DD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

From diverticulosis to complicated diverticular disease: Progression of myogenic alterations and oxidative imbalance

Pallotta,

Pisano,

Vona

et al. 2024

Neurogastroenterology Motil

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View full text Add to dashboard Cite

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Oxidative imbalance and muscular alterations in diverticular disease

Pallotta

Vona²,

Maselli³

et al. 2022

Digestive and Liver Disease

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The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders

et al. 2021

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Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of many diseases. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant systems has been extensively studied in pulmonary, neurodegenerative cardiovascular disorders; however, its contribution is still debated in gastrointestinal disorders. Evidence suggests that oxidative stress affects gastrointestinal motility in obesity, and post-infectious disorders by favoring the smooth muscle phenotypic switch toward a synthetic phenotype. The aim of this review is to gain insight into the role played by oxidative stress in gastrointestinal pathologies (GIT), and the involvement of ROS in the signaling underlying the muscular alterations of the gastrointestinal tract (GIT). In addition, potential therapeutic strategies based on the use of antioxidants for the treatment of inflammatory gastrointestinal diseases are reviewed and discussed. Although substantial progress has been made in identifying new techniques capable of assessing the presence of oxidative stress in humans, the biochemical-molecular mechanisms underlying GIT mucosal disorders are not yet well defined. Therefore, further studies are needed to clarify the mechanisms through which oxidative stress-related signaling can contribute to the alteration of the GIT mucosa in order to devise effective preventive and curative therapeutic strategies

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Myogenic oxidative imbalance interferes with antral motility in obese subjects

Abstract: Antral myogenic activity of obese subjects can be impaired by alterations of signaling pathways induced by oxidative stress.

Cited by 3 publications

References 30 publications

From diverticulosis to complicated diverticular disease: Progression of myogenic alterations and oxidative imbalance

From diverticulosis to complicated diverticular disease: Progression of myogenic alterations and oxidative imbalance

Oxidative imbalance and muscular alterations in diverticular disease

The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders

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