Myofibroblasts and Transforming Growth Factor-Beta1 in Reactive Gingival Overgrowths

Epivatianos, Apostolos; Andreadis, Dimitrios; Iordanidis, Savas

doi:10.5037/jomr.2013.4103

Cited by 5 publications

(2 citation statements)

References 29 publications

(37 reference statements)

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“…TGF-β1 contributes to the formation of collagenous connective tissue and is expressed by large amount of fibroblasts and chronic inflammatory cells in reactive gingival overgrowths [18]. Compared with typical wounds there is a higher ratio of TGF-β1 in fetal wounds.…”

Section: Discussionmentioning

confidence: 99%

Detection of TGF-β1, HGF, IGF-1 and IGF-1R in Cleft Affected Mucosa of the Lip

Sidhom¹,

Pilmane²

2017

TODJ

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Background: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts.

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Section: Discussionmentioning

confidence: 99%

Detection of TGF-β1, HGF, IGF-1 and IGF-1R in Cleft Affected Mucosa of the Lip

Sidhom¹,

Pilmane²

2017

TODJ

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“…12,13 Luka dibiarkan terbuka, tidak ditutup dengan penutup apapun. 14 Pengambilan jaringan luka dilakukan dengan mengorbankan hewan co ba menggunakan eter. Setelah efek tercapai, dilakukan eksisi pada bagi an luka yang paling luas dengan mengikutsertakan jaringan kulit normal, NHPXGLDQ GLÀNVDVL GDODP IRUPDOLQ EXIIHU 10% untuk dilakukan pemeriksaan histopatologi dan imunohistokimia.…”

Section: Metodologi Penelitianunclassified

Perbedaan Indikator-Indikator Penyembuhan Luka Tikus Wistrar Non Diabetik Dan Diabetik Pada Pemberian Curcumin Topikal

Jayadi¹,

Krismi²

2015

berk.ilm.kedokt.duta.wacana.

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ABSTRAK Latar Belakang: Di dunia dan Indonesia, penderita diabetes melitus akan meningkat, diperkirakan dua kali. Hal ini menyebabkan peningkatan jumlah penderita ulkus diabetikum, pada akhirnya dapat menyebabkan amputasi. Banyak faktor pertumbuhan berperan dalam penyembuhan luka, diantaranya TGF beta1 dan p63. Pada luka kronik, ekspresi TGF beta 1 menurun, sementara peran utama p63 adalah pertumbuhan epidermis. Curcumin memperbaiki penyembuhan luka. Tujuan Penelitian: Tujuan penelitian adalah untuk mengenali efek kurkumin pada penyembuhan luka tikus wistar non diabetic dan diabetic dengan menilai ekspresi TGF beta1 dan p63, tingkat inflamasi, jaringan granu%asi, dan penutupan dermis. Metode Penelitian: Penelitian dikerjakan dengan metode quasi eksperimental dengan desain post-test only control group design pada 64 hewan coba, dengan 16 tikus non diabetik diterapi curcumin (A), 16 hewan coba diabetik tanpa curcumin (B), 16 tikus diabetik tanpa curcumin (C), 16 tikus diabetik diterapi salep curcumin (D). Hasil dan Diskusi: Pada uji marginal homogeneity derajat inflamasi sampe% A terhadap sampel B adalah p= 0,166, level ekspresi TGF beta1 nilai p= 0,03, pembentukan jaringan granulasi p= 0,317, penutupan dermis nilai p 0,317 (p= 0,05), ekspresi p63 ni%ai p&O,OOS. +urcumin meningkatkan derajat inflamasi dan %e/e% ekspresi TGF beta1 yang cenderung mempercepat proses penyembuhan luka pada hewan coba non diabetes. Uji marginal homogeneity sampel C dan D menunjukkan inflamasi ni%ai p& O,128, pembentukan jaringan granu%asi p& O,S69, sedang penutupan dermis sampel D p= 0,083, ekspresi TGF beta1 p= 0,884, ekspresi p63 p= 0,025. Curcumin meningkatkan ekspresi p63, tetapi tidak mempercepat proses penyembuhan luka. Kata Kunci: curcumin, TGF beta<1, p63, %e/e% inflamasi, penutupan derma%, waktu penyembuhan luka

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Immunohistochemical Characterization of Gingival Fibromas

Darling

Burnside

et al. 2022

Head and Neck Pathol

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Myofibroblasts and Transforming Growth Factor-Beta1 in Reactive Gingival Overgrowths

Cited by 5 publications

References 29 publications

Detection of TGF-β1, HGF, IGF-1 and IGF-1R in Cleft Affected Mucosa of the Lip

Detection of TGF-β1, HGF, IGF-1 and IGF-1R in Cleft Affected Mucosa of the Lip

Perbedaan Indikator-Indikator Penyembuhan Luka Tikus Wistrar Non Diabetik Dan Diabetik Pada Pemberian Curcumin Topikal

Immunohistochemical Characterization of Gingival Fibromas

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