Myoepithelioma of the Salivary Glands

Kumar, Perikala V.; Sobhani, Seyed Ali; Monabati, Ahmad; Hashemi, Seyed Baseer; Eghtadari, Fardin; Hamidi, Seyed Afshin

doi:10.1159/000326377

Cited by 30 publications

(4 citation statements)

References 7 publications

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“…Interestingly, this report contains cytological findings of each MN case. In MNs, which occur in salivary glands [11], soft tissues [12], and thyroid gland [13], cytological findings revealed the presence of round to oval, spindle, epithelioid, and plasmacytoid cells in the myxoid background, and uniform or round to ovoid nuclei with distributed chromatin and eosinophilic or pale cytoplasm. Differential diagnosis was challenging in all of these reports.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases

et al. 2022

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Myoepithelial neoplasms (MNs) of the lung are extremely rare tumors. Approximately 40 cases of pulmonary MNs have been reported to date. Herein, we report extremely rare cases of different types of pulmonary MN, including cytological features. Case 1 is an 18-year-old female, and case 2 is a 73-year-old female patient. They presented to our hospital with nodules of the lung. Histological examination revealed tumor cells with round to oval nuclei and acidophilic cytoplasm that formed nests or fascicles with mild hyalinized stroma in case 1 and tumors containing the bi-phasic components of a nest-like and fascicle pattern with pleomorphism in case 2. Immunohistochemically, these tumors were positive for cytokeratin (CK) AE1/AE3, CK5/6, vimentin, calponin, and EMA, and focal positive for S-100a protein and alpha smooth muscle actin. The pathological diagnoses in cases 1 and 2 were myoepithelioma and myoepithelial carcinoma, respectively. In conclusion, we encountered two cases of extremely rare MNs that occurred in the lung. This disease can be diagnosed by collecting appropriate cytological and histological findings and should be listed as a differential diagnosis.

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Section: Discussion/conclusionmentioning

confidence: 99%

Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases

et al. 2022

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“…Plasmacytoid myoepitheliomas were diagnosed on FNAC as “plasmacytoma or pleomorphic adenomas.” Those that were diagnosed histologically as myoepithelioma, spindle cell type were diagnosed on FNAC as “spindle cell neoplasm.” Mixed-type myoepitheliomas were diagnosed on FNAC as “inflammatory pseudotumors or pleomorphic adenomas.” This study highlighted the difficulty in differentiating myoepitheliomas from pleomorphic adenomas by cytomorphology. [5]…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall

Gayathri

Raju

et al. 2014

J Oral Maxillofac Pathol

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“…There have only been a few studies of the cytologic features and diagnostic accuracy for myoepithelioma and basal cell adenoma [8,9,10,11,12,13,14,15,16,17]. With regard to tumor classification, pleomorphic adenoma, myoepithelioma and basal cell adenoma have recently been viewed as neoplasms on a spectrum separable by the dominance of the participating cell types.…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration Cytology of Benign Salivary Gland Tumors with Myoepithelial Cell Participation: An Institutional Experience of 575 Cases

Ahn

Kim

Oh³

2013

Acta Cytologica

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Objective: The aim of this study was to evaluate the diagnostic accuracy of fine needle aspiration (FNA) cytology of benign salivary gland tumors with myoepithelial cell participation, namely, pleomorphic adenoma, basal cell adenoma and myoepithelioma, at a single institution over a period of 10 years. Study Design: This study was based on 575 cytologic and matching histological samples (534 pleomorphic adenomas, 26 basal cell adenomas and 15 myoepitheliomas). Results: In most cases (393/534) of pleomorphic adenoma, a precise diagnosis was given. However, only 2 cases of basal cell adenoma and 1 case of myoepithelioma were diagnosed definitively. Descriptive diagnosis, instead of a definite diagnosis, was rendered in 16.9% of pleomorphic adenomas, 53.8% of basal cell adenomas and 40.0% of myoepitheliomas. Among all cases, the possibility of malignancy was raised in 5.2% of pleomorphic adenomas, 15.4% of basal cell adenomas and 20.0% of myoepitheliomas with a variable degree of suspicion. Conclusion: In some cases, the distinction between these three neoplasms remains difficult in that all exhibit some degree of myoepithelial participation. However, FNA showed a high diagnostic accuracy in diagnosing benign salivary tumors with myoepithelial differentiation, and triage into this category provides sufficient information for clinicians to make treatment decisions.

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Myoepithelioma of the Salivary Glands

Cited by 30 publications

References 7 publications

Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases

Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases

Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall

Fine Needle Aspiration Cytology of Benign Salivary Gland Tumors with Myoepithelial Cell Participation: An Institutional Experience of 575 Cases

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