Myoepithelioma of the Parotid Gland: A Case Report and Literature Review

A giant benign myoepithelioma of the palate: report of a case

“…ME was once considered a variant of pleomorphic adenoma but it is now recognised as a distinct entity. However, the rarity and different phenotypic expression of myoepithelial cells may cause diagnostic di culties leading to ME being diagnosed as pleomorphic adenoma because of clinical and histological similarities [13].MEs present with different morphologies: nonmyxoid (solid), myxoid (pleomorphic adenoma-like), reticular (canalicular-like), and mixed [6,10]. The parenchyma ME exhibits various histological features based on the morphological architecture of the neoplastic myoepithelial cells: spindle type, hyaline type, epithelial type, or clear-type tumor cells [1].…”

“…The parenchyma ME exhibits various histological features based on the morphological architecture of the neoplastic myoepithelial cells: spindle type, hyaline type, epithelial type, or clear-type tumor cells [1]. Among these subtypes spindle cell and plasmacytoid variants are most frequent [12,13,14,15]. The plasmacytoid cell type is most common on the palate.…”

“…The most common site of occurrence is the parotid gland (40-50%), followed by the minor salivary glands mostly on the hard palate (21%). Among the minor salivary glands ME is most common in the soft and hard palate, however, it constitutes 93% of the minor salivary glands with 7% occurring in the gingiva, cheek, and lips (only three cases in the literature to date) [1].ME of the salivary glands has no typical clinical features but shares similar features to most other salivary gland tumors and presents as an asymptomatic, slow-growing mass [12,13]. The ME in our case grew slowly over 27 years without any signi cant symptoms.…”

“…Our case presented as a bony hard tumor suggestive of lesions such as osteoma, ossifying broma, and brous dysplasia. Kumar et al reported that 8 cases (3 females and 5 males) of the plasmacytoid cell type on the palate had been reported during the period 1973 to 2017: 3 females and 5 males [13]. Benign MEs present rare mitosis and absence of nuclear and cellular pleomorphism as well as non-in ltrative growth typical of a benign tumor [15].…”