Myoepithelioma-like hyalinizing epithelioid tumor of the foot with OGT-FOX03 fusion gene: Imaging findings, surgical implications, and pathological correlates

Boldig, Kimberly; Montanarella, Matthew; Fu, Weibo; So, Jennifer M; Lucke, Jacqueline C; Taylor, Kristin; Piraino, Jason; Rohatgi, Abhinav

doi:10.1016/j.radcr.2022.12.014

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…18 There are also case reports of myoepithelioma-like hyalinizing epithelioid tumor found to have OGT::FOXO fusions including fusions with FOXO1 and FOXO3. 19,20 Furthermore, there are rare cases of biphenotypic sinonasal sarcoma harboring PAX3::FOXO1 fusions (2% and 7% in a series of 41 and 44 cases, respectively), which is usually characterized in approximately 90% of cases by a PAX3::MAML3 fusion. 21,22 Antonescu et al 9 reported that their novel GATA6::FOXO1 fusion identified in a subset of EHs represents the first vascular neoplasm involving a FOXO1 fusion.…”

Section: Discussionmentioning

confidence: 99%

Cellular Cutaneous Epithelioid Hemangioma Harboring the Rare GATA6::FOXO1 Gene Fusion

Tepp,

Agaram,

Chang

et al. 2024

The American Journal of Dermatopathology

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Epithelioid hemangioma (EH) is a benign vascular tumor displaying diverse histomorphologies. Among these, one EH subtype comprises cellular sheets of atypical epithelioid cells, posing potential challenges in distinguishing it from malignant vascular lesions. In this case report, we present a cutaneous cellular EH that carries the rare GATA6::FOXO1 gene fusion, a recent discovery. Our aim is to provide an updated insight into the evolving knowledge of EHs while delving into the histologic and molecular characteristics of the primary differential diagnoses.

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Section: Discussionmentioning

confidence: 99%

Cellular Cutaneous Epithelioid Hemangioma Harboring the Rare GATA6::FOXO1 Gene Fusion

Tepp,

Agaram,

Chang

et al. 2024

The American Journal of Dermatopathology

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“…The increased O-GlcNAcylation of FoxO1 was observed in diabetes, resulting in the activation of FoxO1 and regulating antioxidative stress in response to glucose metabolism [ 145 ]. Recent findings that identified OGT-FoxO1/3 gene fusion in multiple tumors suggest that the O-GlcNAc/FoxOs axis may be the basis for these observations [ 146 , 147 ]. Another study observed the nuclear translocation of FoxO1 and increased autophagy flux in a hyperglycemic environment [ 148 ].…”

Section: O-glcnacylation: At the Crossroads Of Oxidative Stress And A...mentioning

confidence: 99%

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

Li,

Ren,

Zheng

et al. 2024

Cell Commun Signal

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O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-translational modification (PTM) involving the covalent binding of serine and/or threonine residues, which regulates bone cell homeostasis. Reactive oxygen species (ROS) are increased due to oxidative stress in various pathological contexts related to bone remodeling, such as osteoporosis, arthritis, and bone fracture. Autophagy serves as a scavenger for ROS within bone marrow-derived mesenchymal stem cells, osteoclasts, and osteoblasts. However, oxidative stress-induced autophagy is affected by the metabolic status, leading to unfavorable clinical outcomes. O-GlcNAcylation can regulate the autophagy process both directly and indirectly through oxidative stress-related signaling pathways, ultimately improving bone remodeling. The present interventions for the bone remodeling process often focus on promoting osteogenesis or inhibiting osteoclast absorption, ignoring the effect of PTM on the overall process of bone remodeling. This review explores how O-GlcNAcylation synergizes with autophagy to exert multiple regulatory effects on bone remodeling under oxidative stress stimulation, indicating the application of O-GlcNAcylation as a new molecular target in the field of bone remodeling. Graphical Abstract

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Myoepithelial tumors of soft tissue and bone in children and young adults: A clinicopathologic study of 40 cases occurring in patients ≤ 21 Years of age

Logan,

Dehner,

Alruwaii

et al. 2024

Human Pathology

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Myoepithelioma-like hyalinizing epithelioid tumor of the foot with OGT-FOX03 fusion gene: Imaging findings, surgical implications, and pathological correlates

Cited by 5 publications

References 14 publications

Cellular Cutaneous Epithelioid Hemangioma Harboring the Rare GATA6::FOXO1 Gene Fusion

Cellular Cutaneous Epithelioid Hemangioma Harboring the Rare GATA6::FOXO1 Gene Fusion

Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling

Myoepithelial tumors of soft tissue and bone in children and young adults: A clinicopathologic study of 40 cases occurring in patients ≤ 21 Years of age

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