Myoepithelial Tumors

Jo, Vickie Y.

doi:10.1016/j.path.2015.05.005

Cited by 43 publications

(55 citation statements)

References 48 publications

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“…These findings suggest that a subset of ECTs share common genetic aberrations with the EWSR1 ‐positive myoepithelial neoplasms of soft tissues. In the current study, we did not investigate the identity of the fusion partner genes, although a variety of different fusion partners have been reported in soft tissue myoepitheliomas, including POU5F1 (6q21), PBX1 (1q23), ZNF444 (19q23), and ATF1 (12q13) . In addition to EWSR1 rearrangement, we observed gain of EWSR1 in 89% (8/9) of the specimens.…”

Section: Discussionmentioning

confidence: 64%

“…In the current study, we did not investigate the identity of the fusion partner genes, although a variety of different fusion partners have been reported in soft tissue myoepitheliomas, including POU5F1 (6q21), PBX1 (1q23), ZNF444 (19q23), and ATF1 (12q13). 13,14 In addition to EWSR1 rearrangement, we observed gain of EWSR1 Table 1). A, Lobular proliferation of neoplastic cells separated by thin fibrovascular septa.…”

Section: Discussionmentioning

confidence: 80%

“…1,2,9 Recent studies on the cytogenetic abnormalities of soft tissue myoepithelial tumours have identified two separate and apparently genetically unrelated groups of myoepithelial neoplasms lacking ductal differentiation: 10 salivary gland-type myoepithelial tumours, frequently showing pleomorphic adenoma gene 1 (PLAG1) rearrangements; 11 and myoepithelial tumours of the soft tissue type, frequently showing EWS RNA-binding protein 1 gene (EWSR1) rearrangement or, rarely, fused in sarcoma gene (FUS) rearrangement. [12][13][14] In contrast, soft tissue tumours with both myoepithelial and ductal differentiation show PLAG1 abnormalities, 10 akin to pleomorphic salivary adenomas.…”

Section: Introductionmentioning

confidence: 99%

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A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases

et al. 2016

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases

et al. 2016

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“…Primary myoepithelial tumors of soft tissue present in a slightly younger age group on average, but with significant overlap, and they similarly are most common in the limb girdles and extremities. 28 Microscopically, myoepithelial tumors share the low-power magnification lobularity and circumscription, but they are less likely to have a dense, fibrous capsule. Similar to OFMT, the constituent cells are often epithelioid and set within a chondromyxoid stroma, often in a mixed corded, reticular, and nested growth pattern, although a reticular pattern is much more common in myoepithelial tumors (Figure 3, A and B).…”

Section: Myoepithelial Neoplasmsmentioning

confidence: 99%

Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis

Carter

Patel

2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Ossifying fibromyxoid tumor (OFMT) is a rare, slow-growing mesenchymal neoplasm of uncertain histogenesis with intermediate malignant potential. Objective.— To highlight the most important diagnostic features, including morphologic, immunohistochemical, and molecular findings; to provide comparisons to other entities in the differential diagnosis; and to provide a summary of the clinical features and outcomes in cases reported to date. Data Sources.— The data sources include recently published literature encompassing OFMT and tumors in the histologic differential diagnosis, and cases from institutional files. Conclusions.— Ossifying fibromyxoid tumor is important to recognize because of its low-grade morphology but potential for recurrence and metastasis. Recent molecular analysis has expanded the morphologic spectrum of OFMT, with additional cases discovered that are enriched for aggressive behavior. The diagnosis can often be rendered through a combination of morphology and coexpression of S100 protein and desmin, although only a minority of cases described contain all of these primary features. In cases that do not have all of these features, a high index of suspicion guided by morphology and exclusion of other tumors in the histologic differential diagnosis can lead to the correct diagnosis. Growing access to molecular genetic testing will become increasingly important for correct diagnosis of tumors at the ends of the morphologic spectrum.

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“…Myoepithelioma is a rare tumor that is composed of myoepithelial cells . It more commonly affects the salivary glands, but may occur in other locations, including breast, skin, lung, soft tissue, and bone .…”

mentioning

confidence: 99%

EWSR1‐PBX3 fused myoepithelioma arising in metatarsal bone: Case report and review of the literature

Yun

Kim

Cho

et al. 2019

Pathology International

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Intraosseous myoepithelial tumors are very rare. Due to the low incidence and diverse histologic features, accurate diagnosis is challenging, necessitating ancillary immunohistochemistry. Moreover, genetic abnormality in this tumor was not revealed until recently. Although EWSR1 translocation is involved in half of the cases of intraosseous myoepithelioma, only a few cases have indicated its counterpart gene. We herein describe a case of intraosseous myoepithelioma with a novel localization in the fourth metatarsal bone of a 36-year-old female.Cytogenetic analysis using next generation sequencing detected a rare EWSR1-PBX3 fusion. Next generation sequencing could be useful in understanding the cytogenetic characteristics of intraosseous myoepithelioma, and in obtaining an accurate diagnosis of this rare condition.

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Myoepithelial Tumors

Cited by 43 publications

References 48 publications

A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases

A subset of ectomesenchymal chondromyxoid tumours of the tongue show EWSR1 rearrangements and are genetically linked to soft tissue myoepithelial neoplasms: a study of 11 cases

Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis

EWSR1‐PBX3 fused myoepithelioma arising in metatarsal bone: Case report and review of the literature

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