Myoepithelial differentiation in cribriform, tubular and solid pattern of adenoid cystic carcinoma: A potential involvement in histological grading and prognosis

Du, Fei; Zhou, Chuan‐Xiang; Gao, Yan

doi:10.1016/j.anndiagpath.2016.03.001

Cited by 27 publications

(25 citation statements)

References 25 publications

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“…It often occurs in benign mixed tumors, ACC, and salivary duct carcinoma, as well as in EMC, myoepithelioma, and myoepithelial carcinoma . A previous study has suggested that the loss of myoepithelial differentiation might contribute to the poor prognosis of the solid subtype of ACC . Other papers have shown that the proliferation rate of myoepithelial cells was lower than that of basal‐type epithelial cells, and have emphasized the myoepithelial cell's role as a natural defender against cancer invasion .…”

Section: Discussionmentioning

confidence: 99%

“…15 A previous study has suggested that the loss of myoepithelial differentiation might contribute to the poor prognosis of the solid subtype of ACC. 17 Other papers have shown that the proliferation rate of myoepithelial cells was lower than that of basal-type epithelial cells, and have emphasized the myoepithelial cell's role as a natural defender against cancer invasion. 18 On the other hand, a case of ACC of the lacrimal gland with severe myoepithelial differentiation was reported to present an aggressive clinical behavior.…”

Section: Discussionmentioning

confidence: 99%

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High‐grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma

Tando

Nagao

Kayano

et al. 2017

Pathology International

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High-grade transformation (HGT)/dedifferentiation is an unusual phenomenon in salivary gland carcinomas. Here we report a case of adenoid cystic carcinoma (ACC) with HGT/dedifferentiation to myoepithelial carcinoma, occurring in the epipharynx of a 42-year-old woman. The surgically resected tumor was a pedunculated mass, 31 × 25 mm in size, which had two histologically distinct carcinomatous areas, including a high-grade sarcomatoid area composed of pleomorphic spindle cells and an area consisting of low-grade typical ACC. These two components gradually changed from the low-grade to the high-grade component. MIB-1 index in the low-grade and high-grade component was 15% and 50%, respectively. An immunohistochemical profile of the high-grade component showed immunoreactivity for α-SMA, p63, calponin and focal S100, as well as for several cytokeratin markers, which were compatible with the features of myoepithelial carcinoma. In contrast, the immunohistochemical profile of the low-grade component coincided with that of typical ACC. This HGT/dedifferentiation to myoepithelial carcinoma is extremely rare. The pathogenesis of HGT/dedifferentiation in salivary gland carcinomas still remains largely unknown, regardless of the presence or absence of myoepithelial differentiation. Further studies are required due to the more aggressive biological behavior and poorer prognosis associated with ACC with HGT/dedifferentiation, compared with conventional ACC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High‐grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma

Tando

Nagao

Kayano

et al. 2017

Pathology International

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“…On a retrospective analysis and comparison of immunoprofiles with architecture, it is seen that those cases of adenoid cystic carcinoma and polymorphous adenocarcinoma which showed p63-ve/p40-ve profile have high grade morphology and predominant solid pattern. In another study by Du et al, (2016), they studied myoepithelial differentiation in 109 adenoid cystic carcinomas including 38 cribriform, 35 solid and 36 tubular subtypes. They concluded that solid pattern of adenoid cystic carcinoma showed loss of myoepithelial differentiation and are associated with more aggressive behavior and poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma

Atiq

Mushtaq

Hassan

et al. 2019

Asian Pac J Cancer Prev

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Objective: Adenoid cystic carcinoma and polymorphous adenocarcinoma are primarily the tumor of minor salivary glands. Both show certain morphological similarities, which limit their proper diagnosis in settings where there are obscuring factors and limited biopsy material. However, there is a considerable difference in treatment and prognosis, which raises the need to distinguish these two entities. In this study, we discuss the utility of two immunohistochemical stains, p63 and p40, in different combinations for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma. Materials and Methods: Two immunohistochemical stains, p63 and p40, were performed on 47 cases of adenoid cystic carcinoma and 23 cases of polymorphous adenocarcinoma. Results: 36 out of 47 cases of adenoid cystic carcinoma showed p63+ve/p40+ve immunoprofile, followed by p63-ve/p40-ve immunoprofile, which is seen in10 cases of adenoid cystic carcinoma. However, 22 out of 23 cases of polymorphous adenocarcinoma displayed p63+ve/ p40-ve immunoprofile. p63-ve/p40+ve is the least frequent observed immunoprofile, which is seen in only one case of adenoid cystic carcinoma. Conclusion: On combining all possible immunoprofile combinations, p63+ve/p40-ve immunoprofile appears to be the most sensitive profile for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma.

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“…Recently, Van Weert et al proposed the presence of a solid pattern regardless of its quantity is a poor prognosticator. Anyway, the solid growth pattern is related to more aggressiveness, poorer short-term survival and probably higher risk of nodal metastasis and early distant metastasis 9 . In many of the studies, a solid growth pattern is associated with worse prognosis, advanced stage and development of distant metastases 10,14 Neural invasion can be seen even in early-stage tumors and has been regarded as an unfavorable prognostic factor, associated with distant metastasis and adverse final outcome 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Although almost 40 histological types of SGTs exist, some are exceedingly rare 8 .Histopathologically, AdCC is identified as a tumor with biphasic differentiation of epithelial and myoepithelial cell (MEC), which often shows mixed patterns of cribriform, tubular and solid types 9 . Here we report a case of AdCC in 60yr old female patient on the anterolateral surface of mobile part of the tongue.…”

mentioning

confidence: 99%

Adenoid Cystic Carcinoma of Tongue: A Case Report & Review of Literature

K¹,

Sudha²,

C.M³

et al. 2017

IOSR JDMS

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Myoepithelial differentiation in cribriform, tubular and solid pattern of adenoid cystic carcinoma: A potential involvement in histological grading and prognosis

Cited by 27 publications

References 25 publications

High‐grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma

High‐grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma

Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma of Tongue: A Case Report & Review of Literature

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