Myoepithelial carcinoma of the stomach: A diagnostic pitfall

Tseng, Chih-En; Hsieh, Yu–Hsi; Wei, Chang‐Kuo; Huang, Hsuan-Ying; Chi, Chen-Lin

doi:10.3748/wjg.v21.i14.4391

Cited by 5 publications

(8 citation statements)

References 14 publications

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“…The absence of obvious malignant features in most reported cases of MECAs make the diagnosis of malignancy difficult on cytological smears. [ 1 8 ] Savera et al . classify MECA into low-grade lesions and high-grade lesions based on nuclear parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically malignant features of myoepithelial neoplasm include infiltrative and destructive into the surrounding structures, multinodular architecture and zonal cellular arrangement, perineural and vascular invasion. [ 5 8 23 ] Unfortunately, these features cannot be assessed on cytology sample. Hence, histopathology is mandatory to reach the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 3 4 5 ] MECAs have been described in other sites such as lungs, skin, breast, stomach, and soft tissues. [ 6 7 8 9 ] The mean age at presentation is in the fifth to sixth decade and in general, MECAs exhibit no gender predilection, with the exception of primary lung MECAs that affect males more than females. The majority of patients with head and neck tumors present with the primary complaints of a painless mass with duration of symptoms ranging from 2 months to 7 years.…”

Section: Introductionmentioning

confidence: 99%

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Pleural fluid metastases of myoepithelial carcinoma: A case report and review of the literature

et al. 2016

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Myoepithelial carcinoma (MECA) is one of the rarest salivary gland neoplasms, which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The tumor occurs mainly in the parotid gland followed by minor salivary glands and other body sites. As a result of their morphologic heterogeneity, they can be confused easily with many tumors. Awareness of their unique cytoarchitectural patterns and immunohistochemical profile is crucial for accurate identification. Herein, we report a rare case of a 51-year-old female patient with MECA of the maxillary sinus that metastasized to the pleural fluid. To the best of our knowledge, this is the first case of pleural fluid involvement by MECA reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pleural fluid metastases of myoepithelial carcinoma: A case report and review of the literature

et al. 2016

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“…The sex distribution was approximately equal, with a mean age of 38 years, and the primary complaint of MC was a painless mass located in the parotid gland, oral cavity, or neck[ 3 ]. MC can also originate in the chest, lungs, skin, and stomach[ 4 - 6 ]. Due to the low incidence of MC, the clinical and biological behaviors have not yet been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Esophageal myoepithelial carcinoma: Four case reports

Lu¹,

Zhao²,

Liu³

et al. 2022

WJCC

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BACKGROUND Myoepithelial carcinoma (MC) is a rare malignant neoplasm that mainly occurs in the salivary gland. MC can be confused with many other tumors when arising outside the salivary glands because it presents with a wide spectrum of cytomorphological and immunohistochemical features. To the best of our knowledge, esophageal MC has not been previously reported. The purpose of this study was to describe the imaging and clinicopathological features of esophageal MC to improve the understanding of the disease. CASE SUMMARY Three men and one woman diagnosed with esophageal MC were enrolled in this study. The primary clinical symptom was dysphagia. The mass was mainly located in the middle esophagus. Laboratory tests revealed that two patients who underwent tumor abnormal protein were positive. Radical resection was performed for all patients with no adjuvant therapy. Hematoxylin-eosin staining showed infiltrative growth of epithelial cells with hyperchromatic and pleomorphic nuclei toward the periphery. Immunohistochemistry showed that all patients were positive for P63, and most patients were positive for SOX-10, AE1/AE3, P40, and calponin. The Ki-67 values were all higher than 60%. Patient one died one month after discharge from an unknown cause. Patient two lost to follow-up. At patient three’s four-month review, enhanced computed tomography (CT) showed anastomosis recurrence and bilateral lung metastases. He abandoned treatment and lost to follow-up. Patient four attended review appointments regularly and remained in a good general condition. CONCLUSION Here, we present the first report of esophageal MC and review the relevant literature. Esophageal MC is more likely to occur in the middle esophagus in older patients with male dominance. A fungating type observed on CT scanning may help narrow down the differential diagnosis. Cystic change or necrosis may occur in larger lesions. The final diagnosis should be made according to the pathological examination. The treatment for MC is surgical resection, and the efficacy of chemotherapy needs to be determined with future studies.

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“…[ 1 ] These tumors arise commonly in salivary glands and very rarely in skin, soft tissue, retroperitoneum, breast, vulva, stomach, and lung. [ 2 3 4 5 6 7 ] Myoepithelial carcinoma of the breast is extremely rare, and <40 case reports have been published in English literature. Most of the reports lay emphasis on diagnosis and pathology and very few mention of the chemotherapy regimen used and its response.…”

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confidence: 99%